A5090089348- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Leprosy Research and Treatment
- Galectins and Cancer Biology
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Veterinary medicine and infectious diseases
- Microbial Metabolites in Food Biotechnology
- Insect Pest Control Strategies
- Mosquito-borne diseases and control
- Hemoglobinopathies and Related Disorders
- Hematological disorders and diagnostics
- Malaria Research and Control
- Phytochemistry and Bioactive Compounds
- Skin Protection and Aging
- Clostridium difficile and Clostridium perfringens research
- Oral and gingival health research
- Skin Diseases and Diabetes
- Gastrointestinal disorders and treatments
- Hypothalamic control of reproductive hormones
- Dental Radiography and Imaging
- Pharmacological Effects and Toxicity Studies
- Phytase and its Applications
- Cardiovascular and Diving-Related Complications
- Nonmelanoma Skin Cancer Studies
Universidad Autónoma de Santo Domingo
2014-2024
Philippine Medical Association
2019
Czech Academy of Sciences, Institute of Microbiology
2015
Universidad Tecnológica de Santiago
2015
Center for Research and Advanced Studies of the National Polytechnic Institute
2005
University of Portsmouth
2003
Osaka University
1999-2002
Instituto de Investigación Sanitaria La Fe
1985
Innate immunity plays important roles in the primary defense against pathogens, and epidemiological studies have suggested a role for Toll-like receptor 1 (TLR1) Helicobacter pylori susceptibility. Microarray analysis of gastric biopsy specimens from H. pylori–positive uninfected subjects showed that TLR10 messenger RNA (mRNA) levels were upregulated approximately 15-fold infected subjects; these findings confirmed by real-time quantitative polymerase chain reaction analysis....
Abstract Helicobacter pylori , a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to development genetically distinct H. subpopulations associated geographic origin host and differential disease risk. Here, we provide insights into population structure as part Genome Project ( Hp GP), multi-disciplinary initiative aimed at elucidating pathogenesis identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from...
Abstract Helicobacter pylori disturbs the stomach lining during long-term colonization of its human host, with sequelae including ulcers and gastric cancer 1,2 . Numerous H. virulence factors have been identified, showing extensive geographic variation 1 Here we identify a ‘Hardy’ ecospecies that shares ancestry ‘Ubiquitous’ from same region in most genome but has nearly fixed single-nucleotide polymorphism differences 100 genes, many which encode outer membrane proteins host interaction...
The purpose of this study was to evaluate the usefulness double arterial phase CT for detection small hypervascular hepatocellular carcinomas, using an automated bolus-tracking technique initiate hepatic CT.Double and late contrast-enhanced helical scans were obtained on 287 consecutive patients suspected having carcinoma. These included 56 with 90 (< or 3 cm) carcinomas 50 no carcinomas. these interpreted by three reviewers. first scan initiated automatically 10 sec after program detected...
The human glycoprotein PC-1 codon Q121 allele has been correlated with insulin resistance, but not type 2 diabetes or obesity. We investigated the prevalence of in Dominican Republic population (755 subjects studied) and whether this variant is associated obesity, diabetes. was high compared that other populations. proportions genotypes detected were: KK, 21.6%; KQ, 48.3%; QQ, 30.1%. This compares to approximately 74%, 24%, 2% Among nonobese, nondiabetic subjects, response KQ (P = 0.027) QQ...
Although the incidence of gastric cancer in Dominican Republic is not high, disease remains a significant health problem. We first conducted detailed analysis Helicobacter pylori status Republic. In total, 158 patients (103 females and 55 males; mean age 47.1±16.2 years) were recruited. The H. infection was determined based on four tests: rapid urease test, culture histological test immunohistochemistry. cagA vacA genotypes examined using PCR gene sequencing. overall prevalence 58.9 %. No...
The interleukin-17 (IL-17) family of cytokines (IL-17A to IL-17F) is involved in many inflammatory diseases. Although IL-17A recognized as being the pathophysiology Helicobacter pylori-associated diseases, role other IL-17 cytokine members remains unclear. Microarray analysis was performed H. pylori-infected and uninfected gastric biopsy specimens. IL-17C mRNA upregulated approximately 4.5-fold This confirmed by quantitative reverse transcriptase PCR infected mucosa obtained from Bhutan...
AbstractHelicobacter pylori antibiotic susceptibility in the Dominican Republic has not been monitored. We assessed H. Republic, and analyzed mutations associated with resistance. recruited 158 dyspeptic patients Santo Domingo used agar dilution to test five antibiotics. Polymerase chain reaction-based sequencing was assess gyrA, gyrB, rdxA, frxA, 23S rRNA mutations; next-generation identify other metronidazole resistance-associated genes. Among 64 strains isolated, we identified two (3.1%),...
Abstract The objective of this investigation was to know whether the organophosphate temephos resistance developed in larvae from a laboratory strain Aedes aegypti (Linnaeus, 1762) Cuba could be reversed. resistant Ae. aegypti, named SAN-F6, left without selection pressure for 12 generations. level determined using WHO bioassays and mechanisms metabolic were based on enzyme activity levels detected by biochemical assays. Bioassays assays conducted SAN-F6 parental every three reversal...
In this study, insecticide resistance and the mechanisms responsible were characterized in Ae. aegypti of Boyeros municipality from Havana, Cuba. represents a high epidemiological risk because it is located near Havana International Airport, highly urbanized, has large influx people endemic countries so that qualifies as sentinel site for surveillance. The larvae collected five areas showed to temephos associated with metabolic enzymes. adult mosquitoes displayed deltamethrin less distinctly...
The prevalence of Helicobacter pylori resistance to levofloxacin and metronidazole was high in the Dominican Republic. We used two-fold agar dilution method determine minimum inhibitory concentration five alternative antibiotics 63 strains. also assessed genetic mutations associated with antibiotic using next-generation sequencing. revealed that all strains were sensitive towards sitafloxacin, furazolidone, rifabutin. In contrast, rifaximin garenoxacin (82.5% 34.9%, respectively). Patients...
Summary A puffed product was made by extruding corn flour supplemented with soybean and safflower pastes. Mixes the following proportions of flour, pastes: (i) 89:8:3, (ii) 83:11:6 (iii) 80:17:3 were extruded. The pastes used had 6.6%, 45.9% 32.9% protein content respectively. In addition, paste contained 11.78 units inhibited trypsin/mg sample, which means it appropriate for human consumption. Sensory evaluation extruded products showed that there no significant differences in flavour,...
Abstract Background Helicobacter pylori , a bacterium that infects the human stomach, has high genetic diversity. Because its evolution is parallel to human, H. used as tool trace migration. However, there are few studies about relationship between phylogeography of and host human. Methods We examined both DNA mitochondrial Y-chromosome obtained from total 119 patients in Dominican Republic, where demography consists various ancestries. extracted cultured were analyzed by multi locus...
Objective: This systematic review assessed available published data related to the prevalence of multidrug-resistant tuberculosis (MDR-TB) in Dominican Republic (DR). The MDR-TB DR is among highest Americas. To better understand barriers associated with increasing rates MDR-TB, a focused effort must be made identification actual present DR. As 2024, there remains much variability limited amount regarding Methods: A database search was conducted Medline via PubMed, Cochrane Library, CINAHL...
Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic