A5078331917- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Colorectal Cancer Screening and Detection
- Autoimmune and Inflammatory Disorders
- Liver Diseases and Immunity
- Mycobacterium research and diagnosis
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Effects of Radiation Exposure
- Veterinary medicine and infectious diseases
- Cancer Immunotherapy and Biomarkers
- Autoimmune Bullous Skin Diseases
- Gastrointestinal Bleeding Diagnosis and Treatment
- Dysphagia Assessment and Management
- Immunodeficiency and Autoimmune Disorders
Alexandra Hospital
2015-2025
Alexandra Hospital
2008-2021
National and Kapodistrian University of Athens
2006-2020
Weatherford College
2020
University Gastroenterology
2002-2019
Senologic Hellenic Society
2016
Aretaeio Hospital
2014
Imerys (Greece)
2007
Pasteur Hellenic Institute
2005
National Institutes of Health
2005
Among the products of enteroendocrine cells are incretins glucagon-like peptide-1 (GLP-1, secreted by L cells) and glucose-dependent insulinotropic peptide (GIP, K cells). These key modulators insulin secretion, glucose homeostasis, gastric emptying. Because rapid early rise GLP-1 in plasma after oral glucose, we wished to definitively establish absence or presence cells, as well relative distribution incretin cell types human duodenum. We confirmed proglucagon pro-GIP genes, their products,...
Abstract Background and Aims This study aimed to compare real-world clinical effectiveness safety of vedolizumab, an α4β7-integrin inhibitor, anti-tumour necrosis factor-α [anti-TNFα] agents in biologic-naïve ulcerative colitis [UC] Crohn’s disease [CD] patients. Methods was a 24-month retrospective medical chart adult UC CD patients treated with vedolizumab or anti-TNFα Canada, Greece the USA. Inverse probability weighting used account for differences between groups. Primary outcomes were...
ABSTRACT We studied the potential inhibitory effect of Lactobacillus casei strain Shirota (from fermented milk product Yakult [Yakult Ltd., Tokyo, Japan]) on Helicobacter pylori by using (i) in vitro inhibition assays with H. SS1 (Sydney 1) and nine clinical isolates (ii) vivo mouse model infection over a period 9 months. In activity against all was observed presence viable L. cells but not cell-free culture supernatant, although there profound urease activity. experiments were performed...
Extraintestinal manifestations [EIMs] are common in inflammatory bowel disease [IBD]. Data on epidemiology and risk factors of EIMs IBD patients limited. The aim this study was to investigate the prevalence a large cohort Greek identify for their development.The population consisted patients, who were followed eight tertiary hospitals. Demographic clinical characteristics analysed. diagnosis based standard criteria specialist consultation.In total, 1860 (1001 with Crohn's [CD], 859...
Abstract Helicobacter pylori , a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to development genetically distinct H. subpopulations associated geographic origin host and differential disease risk. Here, we provide insights into population structure as part Genome Project ( Hp GP), multi-disciplinary initiative aimed at elucidating pathogenesis identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from...
Gastrointestinal angiodysplasias (GIADs) may be the cause of recurrent bleeding, despite endoscopic treatment.To evaluate effect long-acting somatostatin analogues on blood transfusion requirements, in patients with refractory bleeding due to GIADs.Consecutive from GIADs were enrolled. They received analogue treatment for at least 6 months. The efficacy was evaluated terms transfusions, frequency episodes and haemoglobin level during months (Period During) compared a 6-months' period before...
In clinical settings, Lactobacillus johnsonii La1 administration has been reported to have a favorable effect on Helicobacter pylori-associated gastritis, although the mechanism remains unclear. We administered, continuously through water supply, live H. pylori-infected C57BL/6 mice and followed colonization, development of gastritis in lamina propria, levels proinflammatory chemokines macrophage inflammatory protein 2 (MIP-2) keratinocyte-derived cytokine (KC) serum gastric tissue over...
Abstract Background Upadacitinib is an oral selective Janus kinase-1 (JAK1) inhibitor, that has been approved for the treatment of moderate to severe Ulcerative Colitis (UC) and Crohn’s Disease (CD). The recommended induction dose 45 mg once daily 8 weeks UC 12 CD, followed, thereafter, by a maintenance 15 or 30mg (for patients with refractory, extensive disease). Our study aims capture experience two tertiary centers on upadacitinib use in refractory CD. Methods This ongoing, prospective...
Upadacitinib is a selective Janus kinase-1 inhibitor, approved for the management of Crohn's disease (CD) by United States Food & Drug Administration. In Greece, upadacitinib was initially available through an early-access program. Our goal to describe real practice experience. This multicenter retrospective cohort study patients with moderate-to-severe CD. The primary endpoint clinical response, defined as reduction ≥3 in Harvey-Bradshaw index. Secondary endpoints included biochemical...
COVID-19 pandemic caused a major crisis, affecting and straining health care systems, including some very advanced ones. The may have also indirectly affected access to for patients with other conditions, not related COVID-19, even in countries overwhelmed by an outbreak.We analyzed compared visits the emergency room (ER) department during same calendar period of 2019 2020 (from March 1 31 each year) our hospital, medium size, tertiary center, located center Athens, which is referral...
Introduction: Aberrant activation of the IL-23/IL-17 axis leads to inflammatory phenotypes with overlapping clinical characteristics.Inhibition IL-17 has mostly an anti-inflammatory effect, but sporadic cases new-onset IBD have been reported.Case description: We present case a 65-year-old male patient Crohn's-like disease after treatment secukinumab for skin psoriasis.Discontinuation inhibitor and high-dose corticosteroid were efficient initially, relapse was noted during...
Abstract Background The incidence of IBD in the elderly has increased recent years1. Aim study was reporting disease and patient characteristics when diagnosis set after 60 years. Methods Data were retrieved retrospectively from patients’ medical records included demographics, phenotype, types treatment mortality. Results Of 1017 registered patients, 133 diagnosed ≥60 years (13.08%). 87 (65.4%) men, mean age at 67.7 (range 61-83). 74 with Crohn's (CD) (55.6%): 34 (45.9%) ileal (L1), 22...
ABSTRACT Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 10.602), while the vacA i1 allele a increased activity (OR, 5.310; CI, 2.295 12.287) severity gastritis 3.862; 1.728 8.632).