A5106524178- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Mosquito-borne diseases and control
- Urinary Tract Infections Management
- Malaria Research and Control
- Pneumonia and Respiratory Infections
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Neonatal Respiratory Health Research
- Biomedical and Engineering Education
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Global Maternal and Child Health
- Ethics in Clinical Research
- Vibrio bacteria research studies
- Immune responses and vaccinations
- Infection Control in Healthcare
- Hepatitis B Virus Studies
- Trypanosoma species research and implications
- Neonatal and fetal brain pathology
- Pediatric health and respiratory diseases
- vaccines and immunoinformatics approaches
- Liver Diseases and Immunity
- Psidium guajava Extracts and Applications
- Medicinal Plants and Neuroprotection
Institut de Recherche en Sciences de la Santé
2022-2025
Centre National de la Recherche Scientifique et Technologique
2022-2023
Instituut voor Tropische Geneeskunde
2021
Institut dal Dicziunari Rumantsch Grischun
2020
Neonatal sepsis is a leading cause of neonatal mortality. New interventions are needed to decrease and mortality in regions with highest burden.To evaluate the efficacy intrapartum azithromycin reduce or mortality, as well maternal infections.This double-blind, placebo-controlled, randomized clinical trial enrolled followed up birthing parents their infants at 10 health facilities The Gambia Burkina Faso, West Africa, between October 2017 May 2021.Participants were assigned random receive...
Two pre-erythrocytic vaccines (R21/Matrix-M and RTS,S/AS01) are now approved for Plasmodium falciparum malaria. However, neither induces blood-stage immunity against parasites that break through from the liver. RH5.1/Matrix-M, a P malaria vaccine candidate, was highly immunogenic in Tanzanian adults children. We therefore assessed safety efficacy of RH5.1/Matrix-M Burkinabe
Abstract In highly endemic countries for hepatitis B virus (HBV) infection, childhood including mother-to-child transmission (MTCT), represents the primary route. High maternal DNA level (viral load ≥ 200,000 IU/mL) is a significant factor MTCT. We investigated prevalence of HBsAg, HBeAg, and high HBV among pregnant women in three hospitals Burkina Faso assessed performance HBeAg to predict viral load. Consenting were interviewed on their sociodemographic characteristics tested HBsAg by...
We conducted a systematic review of healthcare-associated outbreaks and cross-sectional surveys related to the contamination antiseptics, disinfectants, hand hygiene products in healthcare settings low- middle-income countries (PROSPERO CRD42021266271). Risk bias was assessed by selected items ORION MICRO checklists. From 1977 onwards, 13 25 were found: 20 from Asia Africa. Products most associated with water-based chlorhexidine, chlorhexidine-quaternary ammonium compound combinations...
Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PE), particularly Escherichia coli and Klebsiella pneumoniae, have been consistently associated with treatment failure, high mortality morbidity. The emergence of carbapenem resistance among ESBL-PE strains exacerbates the antimicrobial resistance. However, data are very limited in developing countries as Burkina Faso. This study aimed to determine prevalence carbapenemase AmpC-β-lactamase production ESBL-producing E. (ESBL-Ec)...
Abstract Background R21/Matrix-M™ malaria vaccine was recently licensed in young children following good efficacy and induction of high titre antibody responses to the central repeat (NANP) P. falciparum circumsporozoite protein. Variability NANP noted populations assessed according age. Links between gut microbiome immune system mean early life is an important consideration when understanding responses. We investigated relationship these participant factors with Burkinabe infants phase IIb...
Abstract Aim To estimate the weighted prevalence of hepatitis E virus (HEV) antibodies and risk factors among pregnant women in Burkina Faso to evaluate efficiency dried blood spots (DBS) detecting HEV antibodies. Methods We first evaluated DBS by comparing 62 with matched serum samples using recomWell IgG IgM kits (Mikrogen Diagnostik). Anti‐HEV immunoglobulin G (IgG) M (IgM) were identified 491 collected from kits. RNA was tested nested polymerase chain reaction HEV‐antibodies positive....
Introduction: Every 75 seconds, a child under the age of 5 years dies malaria throughout world. Burkina Faso is ravaged by and has responded to disease implementing several strategies including Seasonal Malaria Chemoprevention (SMC). In order make available baseline data for study on efficacy supervised 3 doses SMC distribution, this was intended identify malaria-associated factors in children from 0 59 months old two health districts. Methods: This an analytical cross-sectional study, first...
Abstract Background Low- and middle-income countries face significant challenges in differentiating bacterial from viral causes of febrile illnesses, leading to inappropriate use antibiotics. This trial aimed evaluate the impact an intervention package comprising diagnostic tests, a algorithm, training-and-communication on antibiotic prescriptions clinical outcomes. Methods Patients aged 6 months 18 years with fever or history within past 7 days no focus, suspected respiratory tract...
(1) Background: nasopharynx colonization by resistant Staphylococcus aureus and Streptococcus pneumoniae can lead to serious diseases. Emerging resistance antibiotics commonly used treat infections due these pathogens poses a threat the health system. The present study aimed determine antibiotic susceptibility of S. isolates from febrile children’s under 5 years in Nanoro (Burkina Faso). (2) Methods: bacterial were identified nasopharyngeal swabs prospectively collected 629 children....
Abstract Background In low- and middle-income countries, surveillance of antimicrobial resistance (AMR) is mostly hospital-based and, in view poor access to clinical microbiology, biased more resistant pathogens. We aimed assess AMR among Escherichia coli isolates obtained from urine cultures pregnant women as an indicator for community compared the results with those E. febrile patients previously published studies conducted within same population Nanoro, rural Burkina Faso. furthermore...
Dermatoses are essentially due to infectious or free radical aggression, immunoallergic disor-ders, can be secondary general diseases. To investigate new antimicrobial sources against dermatoses, Opilia amentacea crude ethanol extracts and fractions were subjected phytochemical screening tested for antioxidant activities on Gram-positive cocci, Gram negative bacilli fungi.
 Phytochemical revealed metabolites such as sterols, triterpenes, flavonoids tannins. Leaves stem bark of exhibited...
Abstract Background Two pre-erythrocytic vaccines (R21/Matrix-M and RTS,S/AS01) are now approved for P. falciparum malaria. However, neither induces blood-stage immunity against parasites that breakthrough from the liver. RH5.1/Matrix-M, a malaria vaccine candidate, was highly immunogenic in Tanzanian adults children. We therefore assessed safety efficacy of RH5.1/Matrix-M Burkinabe Methods In this double-blind, randomised, controlled phase 2b trial, given to children aged 5-17 months...
To assess the impact of an intervention package on prescription antibiotic and subsequently rate clinical recovery for non-severe acute febrile illnesses at primary health centers. Patients over 6 months age presenting to care centres with fever or history within past 7 days were randomized receive either constituted point-of-care tests including COVID-19 antigen tests, a diagnostic algorithm training communication packages, standard practice. The outcomes prescriptions Day 0 (D0) (D7)....
Abstract Background: The curative power of antimicrobials is severely threatened due to emerging resistance first-line antibiotics worldwide. With a limited reserve antibiotics, increasing antimicrobial has become global concern, but there paucity such data in Burkina Faso, and the West African region general. Therefore, this study aims determine antibiotic susceptibility profile bacterial species isolated from febrile children under 5 years age Nanoro (Burkina Faso). Methods: Clinical...
Background: After its initial detection in Wuhan, China, December 2019, SARS-CoV-2 has spread rapidly, causing successive epidemic waves worldwide. This study aims to provide a genomic epidemiology of Burkina Faso. Methods: Three hundred and seventy-seven genomes obtained from PCR-positive nasopharyngeal samples (PCR cycle threshold score <35) collected between May 5, 2020, January 31, 2022 were analysed. Genomic sequences assigned phylogenetic clades using NextClade Pango lineages...
Abstract Introduction: In low- and middle-income countries, surveillance of antimicrobial resistance (AMR) is mostly hospital-based and, in view poor access to clinical microbiology, biased more resistant pathogens. We assessed AMR among Escherichia coli isolates obtained from urine cultures pregnant women as an indicator for community compared the results with those E. febrile patients previously published studies conducted within same population Nanoro, rural Burkina Faso. Results: Between...