A5052358059- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Infant Nutrition and Health
- Complement system in diseases
- Salmonella and Campylobacter epidemiology
- Child Nutrition and Water Access
- Bacteriophages and microbial interactions
- Respiratory viral infections research
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
- Clinical Nutrition and Gastroenterology
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Enterobacteriaceae and Cronobacter Research
- Listeria monocytogenes in Food Safety
- Probiotics and Fermented Foods
- Pediatric Hepatobiliary Diseases and Treatments
- Neonatal Respiratory Health Research
- Digestive system and related health
- Child Nutrition and Feeding Issues
- Iron Metabolism and Disorders
- Liver Disease Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
Washington University in St. Louis
2016-2025
University of Calgary
2017-2021
St. Louis Children's Hospital
2005-2020
University of Michigan
2019
World Health Organization
2019
University of Washington
1998-2017
Washington State University
2000-2017
Washington State Department of Health
2017
Mallinckrodt (United States)
2005-2014
Pediatrics and Genetics
2000-2014
Children with gastrointestinal infections caused by Escherichia coli O157:H7 are at risk for the hemolytic–uremic syndrome. Whether antibiotics alter this is unknown.
The widening array of recognized enteric pathogens and the increasing demand for cost-containment sharpen need careful clinical public health guidelines based on best evidence currently available.Adequate fluid electrolyte replacement maintenance are key to managing diarrheal illnesses.Thorough epidemiological evaluation must define severity type illness (e.g., febrile, hemorrhagic, nosocomial, persistent, or inflammatory), exposures travel, ingestion raw undercooked meat, seafood, milk...
To determine the source of and describe a large outbreak Escherichia coli O157:H7 infections in Washington State.Case-control study; environmental investigation; provider-based surveillance for E infections.Chain fast-food restaurants, hospitals, physician offices, local laboratories, health departments.Patients with diarrhea neighborhood controls. A case was defined as culture-confirmed infection or postdiarrheal hemolytic uremic syndrome (HUS) occurring from December 1, 1992, through...
Characterizing the biogeography of microbiome healthy humans is essential for understanding microbial associated diseases. Previous studies mainly focused on a single body habitat from limited set subjects. Here, we analyzed one largest datasets to date and generated biogeographical map that annotates biodiversity, spatial relationships, temporal stability 22 habitats 279 humans.We identified 929 genera more than 24 million 16S rRNA gene sequences habitats, provide baseline inter-subject...
Significance It is increasingly apparent that bacteria in the gut are important determinants of health and disease humans. However, we know remarkably little about how this organ transitions from a sterile/near-sterile state at birth to one soon harbors highly diverse biomass. We show premature infants patterned progression bacterial community only minimally influenced by mode delivery, antibiotics, or feeds. The pace most strongly gestational age, with microbial population assembling...
These guidelines are intended for use by healthcare professionals who care children and adults with suspected or confirmed infectious diarrhea. They not to replace physician judgement regarding specific patients clinical public health situations. This document does provide detailed recommendations on infection prevention control aspects related
<h3>Objective</h3> The technology for the growth of human intestinal epithelial cells is rapidly progressing. An exciting possibility that this system could serve as a platform individualised medicine and research. However, to achieve goal, culture must be enhanced so biopsies from individuals can used reproducibly generate cell lines in short time frame multiple, functional assays performed (ie, barrier function host–microbial interactions). <h3>Design</h3> We created large panel...
Abstract These guidelines are intended for use by healthcare professionals who care children and adults with suspected or confirmed infectious diarrhea. They not to replace physician judgement regarding specific patients clinical public health situations. This document does provide detailed recommendations on infection prevention control aspects related
Journal Article Toxin Genotypes and Plasmid Profiles as Determinants of Systemic Sequelae in Escherichia coli O157:H7 Infections Get access Stephen M. Ostroff, Ostroff Divisions Field Services Bacterial Diseases, Center for Infectious Centers Disease Control, Atlanta, Georgia, the Gastroenterology Diseases (Departments Pediatrics Medicine), University Washington School Medicine, State Department Social Health Services, Seattle Please address requests reprints to Dr. 1600 Clifton Road NE,...
Escherichia coli O157.H7 was found in 10 of 3570 (0.28%) faecal samples from dairy cattle 5 60 herds (8.3%). Several tentative associations with manure handling and feeding management practices on farms were identified. Faecal/urine slurry samples, bulk milk filters negative for E. O157.H7. also isolated 1412 (0.71%) pastured beef 4 25 (16%) herds. The prevalence excretion feedlot 2 600 (0.33%). identification associated colonization by suggests the possibility that human exposure may be...
Worldwide, approximately 1.8 million children die from diarrhea annually, and millions more suffer multiple episodes of nonfatal diarrhea. On average, in up to 40% cases, no etiologic agent can be identified. The advent metagenomic sequencing has enabled systematic unbiased characterization microbial populations; thus, approaches have the potential define spectrum viruses, including novel present stool during acute detection or unexpected viruses would then enable investigations assess...
Escherichia coli O157:H7 is the leading cause of hemolytic uremic syndrome (HUS). Risk factors for development this complication warrant identification.We enrolled children infected with E. within 1 week onset diarrhea in prospective cohort study. The study was conducted 5 states over 9.5 years . primary and secondary outcomes were HUS (hematocrit <30% smear evidence hemolysis, platelet count <150 × 10(3)/µL, serum creatinine concentration > upper limit normal age) oligoanuric HUS....
Bacterial antigen encounter in a preweaning interval is critical for developing antigen-specific tolerance to gut bacteria.