A5014276524- Global Maternal and Child Health
- Malaria Research and Control
- Mosquito-borne diseases and control
- Vaccine Coverage and Hesitancy
- Child Nutrition and Water Access
- Parasites and Host Interactions
- Poverty, Education, and Child Welfare
- Adolescent Sexual and Reproductive Health
- Healthcare Systems and Reforms
- Travel-related health issues
- Health Policy Implementation Science
- Viral Infections and Outbreaks Research
- HIV/AIDS Impact and Responses
- Health Systems, Economic Evaluations, Quality of Life
- Child Nutrition and Feeding Issues
- Mobile Health and mHealth Applications
- Evaluation and Performance Assessment
- HIV/AIDS Research and Interventions
- Viral Infections and Vectors
- Community Health and Development
- Hemoglobinopathies and Related Disorders
- Global Health Care Issues
- Food Security and Health in Diverse Populations
- Diverse Scientific Research Studies
- Hepatitis Viruses Studies and Epidemiology
London School of Hygiene & Tropical Medicine
2016-2025
U.S. President's Malaria Initiative
2025
University of London
2012-2024
Kenya Medical Research Institute
2020-2024
Liverpool School of Tropical Medicine
2018-2024
Webster University
2024
Center for Global Health
2024
Centers for Disease Control and Prevention
2024
Imperial College London
2018-2022
Universidad de Londres
2022
This article provides detailed guidelines for the implementation of systematic method setting priorities in health research investments that was recently developed by Child Health and Nutrition Research Initiative (CHNRI). The target audience proposed are international agencies, large funding donors, national governments policy-makers. process has following steps: (i) selecting managers process; (ii) specifying context risk management preferences; (iii) discussing criteria priorities; (iv)...
<b>Objectives</b> To examine the impact of use rapid diagnostic tests for malaria on prescribing antimicrobials, specifically antibiotics, acute febrile illness in Africa and Asia. <b>Design</b> Analysis<b></b>of nine preselected linked codesigned observational randomised studies (eight cluster or individually trials one study). <b>Setting</b> Public private healthcare settings, 2007-13, Afghanistan, Cameroon, Ghana, Nigeria, Tanzania, Uganda. <b>Participants</b> 522 480 children adults with...
<h2>Summary</h2><h3>Background</h3> Seasonal vaccination with the RTS,S/AS01<sub>E</sub> vaccine combined seasonal malaria chemoprevention (SMC) prevented in young children more effectively than either intervention given alone over a 3 year period. The objective of this study was to establish whether added protection provided by combination could be sustained for further 2 years. <h3>Methods</h3> This double-blind, individually randomised, controlled, non-inferiority and superiority, phase...
There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate reductase (dhfr) genes P. falciparum populations Nigeria, but one previous study has recorded a novel dhps mutation at codon 431 among infections imported to the United Kingdom from Nigeria. To assess how widespread this is parasites different parts country consequently fill gap sulfadoxine-pyrimethamine (SP) resistance data we retrospectively analysed 1000 filter paper blood spots collected...
Background Malaria in pregnancy can have devastating consequences for mother and baby. Coverage with the WHO prevention strategy sub-Saharan Africa of intermittent-preventive-treatment (IPTp) two doses sulphadoxine-pyrimethamine (SP) insecticide-treated-nets (ITNs) is low. We analysed household survey data to evaluate effectiveness antenatal clinics (ANC) deliver IPTp ITNs pregnant women Nyando district, Kenya. Methods assessed systems ANC impact on low birthweight (LBW). Logistic regression...
Access to Human Immunodeficiency Virus (HIV) care has been rolled out in Cameroon the last decade through decentralised delivery of and timely initiation free antiretroviral drugs. We sought describe evolution mortality loss follow up (LTFU) their patient-related determinants at an HIV clinic which is facing significant challenges. A retrospective review point data from patients was conducted June 2012 Nkongsamba Regional Hospital establish LTFU rates. Univariable multivariable Cox...
Background Coverage of malaria in pregnancy interventions sub-Saharan Africa is suboptimal. We undertook a systematic examination the operational, socio-economic and cultural constraints to pregnant women's access intermittent preventive treatment (IPTp), long-lasting insecticide-treated nets (LLINs) case management Kenya Mali provide empirical evidence for strategies improve coverage. Methods Focus group discussions (FGDs) were held as part programme research explore delivery, use control...
Since 2010, the World Health Organization has been recommending that all suspected cases of malaria be confirmed with parasite-based diagnosis before treatment. These guidelines represent a paradigm shift away from presumptive antimalarial treatment fever. Malaria rapid diagnostic tests (mRDTs) are central to implementing this policy, intended target artemisinin-based combination therapies (ACT) patients and improve management nonmalarial fevers. The ACT Consortium conducted ten linked...
There are striking similarities in health system and other contexts between Tanzania Ghana that relevant to the scaling up of continuous delivery insecticide treated nets (ITNs) for malaria prevention. However, specific contextual factors relevance ITN have led implementation down very different pathways two countries. Both countries made major efforts investments address this intervention through integrating consumer discount vouchers into system. Discount require arrangements among public,...
In 2019, the RTS,S/AS01E malaria vaccine was introduced on a pilot basis in six regions of Ghana by Ministry Health/Ghana Health Service as part WHO-coordinated Malaria Vaccine Implementation Programme (MVIP). This is first time vaccination programme has been implemented any country. paper describes challenges faced, and lessons learned, during planning early implementation three out that Ghana.Twenty-one in-depth interviews were conducted with regional district health service managers...
Malaria in pregnancy is associated with increased risks of maternal and foetal complications. Currently, intermittent preventive treatment (IPT) malaria during sulphadoxine-pyrimethamine (SP) recommended by the WHO as part a package interventions also including insecticide-treated nets effective case management. However, increasing resistance to SP, effectiveness SP-IPT has been questioned. A randomized controlled trial (RCT) investigate relative efficacy an alternative strategy screening...
Effective case management of uncomplicated malaria is a cornerstone successful control. With current calls for the global elimination malaria, all strategies to control need reach highest achievable level effective implementation. A systematic literature review interventions improve provider- and/or user-side behavior in prompt and appropriate treatment (with evaluation design Roll Back Malaria outcome indicators) found 23 studies review. Only 16 targeted providers, nine public sector seven...
There is increasing recognition among trialists of the challenges in understanding how particular 'real-life' contexts influence delivery and receipt complex health interventions. Evaluations interventions to change worker and/or patient behaviours service settings exemplify these challenges. When interpreting evaluation data, deviation from intended intervention implementation accounted for through process evaluations fidelity, reach, intensity. However, no such systematic approach has been...
WHO now recommends test-based management of malaria across all transmission settings. The accuracy rapid diagnostic test (RDT) and the outcome treatment based on result tests will influence acceptability adherence to new guidelines.We conducted a study at Kintampo hospital in rural Ghana evaluate performance CareStart, HRP-2 RDT, using microscopy as reference. We applied IMCI guidelines, restricted ACT RDT-positive children followed-up both (malaria) RDT-negative (non-malaria) cases over 28...
Background WHO recommends intermittent-preventive-treatment (IPTp) with sulphadoxine-pyrimethamine (SP) and insecticide-treated-nets (ITNs) to prevent malaria in pregnancy sub-Saharan Africa, however uptake remains unacceptably low. We evaluated the effectiveness of antenatal clinics (ANC) deliver two doses IPTp ITNs pregnant women Segou district, Mali. Methods used household data assess systems ANC logistic regression identify predictors attendance, receipt ITN use during pregnancy, impact...
Children with severe acute malnutrition (SAM) are at high risk of impaired development. Contributing causes include the inadequate intake specific nutrients such as polyunsaturated fatty acids (PUFAs) and a lack adequate stimulation. We conducted pilot study assessing developmental nutritional changes in children SAM provided modified ready-to-use therapeutic food context-specific psychosocial intervention Mwanza, Tanzania. recruited 82 (6–36 months) 88 sex- age-matched non-malnourished...