A5000659672- Tuberculosis Research and Epidemiology
- Parasites and Host Interactions
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Parasite Biology and Host Interactions
- Malaria Research and Control
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- COVID-19 epidemiological studies
- Diagnosis and treatment of tuberculosis
- Iron Metabolism and Disorders
- Gut microbiota and health
- Viral gastroenteritis research and epidemiology
- Parasitic Infections and Diagnostics
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Mosquito-borne diseases and control
- Antibiotic Use and Resistance
- Infectious Diseases and Mycology
- Pregnancy and Medication Impact
- Viral Infections and Outbreaks Research
- Vitamin D Research Studies
- COVID-19 Clinical Research Studies
University of Amsterdam
2018-2024
Centre de Recherche Médicales de Lambaréné
2018-2024
Amsterdam University Medical Centers
2020-2024
German Center for Infection Research
2021-2024
University of Tübingen
2021-2024
Universitätsklinikum Tübingen
2024
Amsterdam UMC Location University of Amsterdam
2018-2023
Albert Schweitzer Hospital
2022
Fonds National de la Recherche
2021
Public Health Service of Amsterdam
2020-2021
The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. question is whether such specificity arises from shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification host microbiota, we analyzed paired metagenomes genomes 1225 individuals Europe, Asia, Africa, including mothers children. Between countries, parallel was...
SummaryBackgroundThe broad use of bedaquiline and pretomanid as the mainstay new regimens to combat tuberculosis is a risk due increasing resistance. We aimed assess safety, bactericidal activity, pharmacokinetics BTZ-043, first-in-class DprE1 inhibitor with strong activity in murine models.MethodsThis open-label, dose-expansion, randomised, controlled, phase 1b/2a trial was conducted two specialised sites Cape Town, South Africa. Adults aged 18–64 years newly diagnosed pulmonary sensitive...
Abstract Background Africa is challenged by the emergence of antimicrobial resistance (AMR). In order to improve patient management and optimise approaches curb spread resistance, we examined knowledge perceptions AMR antibiotics prescription practices HCW (healthcare workers) in Lambaréné, Gabon. Methods We conducted a self-administered, questionnaire-based survey at regional referral hospital, medical research centre, peripheral health care facilities. The proportions correct responses...
Background Malaria burden remains high in the sub-Saharan region where helminths are prevalent and children often infected with both types of parasites. Although effect on malaria infection is evident, impact these co-infections not clearly elucidated yet scarce findings conflicting. In this study, we investigated schistosomiasis, considering soil-transmitted (STH), prevalence incidence Plasmodium falciparum infection. Methodology This longitudinal survey was conducted school-age living two...
Abstract Background Sub-Saharan Africa carries most of the global burden schistosomiasis. To optimize disease control and reduce morbidity, precise data are needed for measures adapted to local epidemiological situation. The objective this study is provide baseline information on schistosomiasis dynamics, including praziquantel (PZQ) treatment outcome in children young adults living vicinity Lambaréné, Gabon. Methods Eligible volunteers were included into a prospective longitudinal study....
Abstract Background In countries with a high tuberculosis incidence such as Gabon, healthcare workers are at enhanced risk to become infected due their occupational exposure. addition, transmission can occur between patients and visitors, if infection is not suspected in time. Knowledge about correct control measures therefore highly relevant settings. Methods We conducted an interviewer-administered knowledge, attitude practice survey amongst 20 facilities all levels the Moyen-Ogooué...
Abstract Background Soil-transmitted helminth (STH) infections are a public health concern in endemic areas. For efficient control, the epidemiology of disease needs to be monitored. This report assesses prevalence, incidence, post-treatment infection (PTI) rate, and risk factors for STH two rural areas Gabon. Method In this longitudinal prospective study, participants aged six 30 years from vicinity Lambaréné selected households using simple randomization process were included followed...
Soil-transmitted helminths (STH) are common in (sub)tropical regions and primarily affect impoverished populations. STHs reside the gut, interacting both with gut microbiota host immunity. Clinical STH detection is laborious often not performed within context of microbiome studies. Here, we assessed whether fecal metagenome data could be used to assess infection, relate infection diversity. We generated 310 metagenomes for mother-child pairs from two different locations Gabon: one rural...
Schistosomiasis is a parasitic infection highly prevalent in Central Africa where it co-endemic with many other infections, including soil-transmitted helminths (STHs). For its optimal control, there need of descriptive epidemiological data for each endemic region. The objective the present study was to determine situation around schistosomiasis Lambaréné, Gabon. A cross-sectional conducted among schoolchildren. One urine sample per day collected on three consecutive days diagnosis using...
To report the prevalence of polyparasitism during pregnancy in Lambaréné region Gabon and its association with newborn birth weight.Pregnant women their third trimester were recruited a prospective study between November 2011 March 2015. Parasite infection status was assessed microscopically stool, urine blood samples. Maternal demographic obstetrical characteristics newborns anthropometric data collected. Multivariable logistic regression used to assess low weight polyparasitism.678 927...
Background Helminths can modulate the host immune response to Plasmodium falciparum and therefore affect risk of clinical malaria. We assessed here effect helminth infections on both immunogenicity efficacy GMZ2 malaria vaccine candidate, a recombinant protein consisting conserved domains GLURP MSP3, two asexual blood-stage antigens P . Controlled human infection (CHMI) was used assess vaccine. Methodology In randomized, double-blind Phase I trial, fifty, healthy, lifelong malaria-exposed...
The quick sequential organ failure assessment (qSOFA) score has been proposed for risk stratification of emergency room patients with suspected infection. Its use simple bedside observations makes qSOFA an attractive option resource-limited regions. We prospectively assessed the predictive ability compared systemic inflammatory response syndrome (SIRS), universal vital (UVA), and modified early warning (MEWS) in a setting Lambaréné, Gabon. In addition, we evaluated different adaptations UVA...
Abstract Background Malaria remains a major public health problem, affecting mainly low-and middle-income countries. The management of this parasitic disease is challenged by ever increasing drug resistance. This study, investigated the therapeutic efficacy, tolerability and safety artemether–lumefantrine (AL) artesunate–amodiaquine (AS–AQ), used as first-line drugs to treat uncomplicated malaria in Lambaréné, Gabon. Methods A non-randomized clinical trial was conducted between October 2017...
Seroconversion surveys of anti-SARS-CoV-2 antibodies provide accurate estimates the SARS-CoV-2 infection. This nationwide population-based cross-sectional serosurvey aimed to evaluate prevalence among residents in Gabon and compare estimated cumulative number COVID-19 cases with officially registered laboratory-confirmed up December 2021. Households each province were randomly selected. Twenty-eight localities including 16 urban 12 rural, selected participate study. Whole blood samples...
BackgroundRespiratory tract microbiota has been described as the gatekeeper for respiratory health. We aimed to assess impact of standard-of-care and experimental anti-tuberculosis treatment regimens on microbiome implications outcomes.MethodsIn this retrospective study, we analysed sputum participants with tuberculosis treated six versus who were part HIGHRIF study 2 (NCT00760149) PanACEA MAMS-TB (NCT01785186) clinical trials across a 3-month follow-up period. Samples from in Mbeya,...
Gabon carries a high burden of both tuberculosis (TB) and smoking. This study examines the disease characteristics smoking pulmonary TB patients in Lambaréné. We interviewed adult Lambaréné, between March 2016 April 2019. Clinical biological patient were collected. Bivariate logistic regression analyses performed to assess factors associated with The mean age included was 31 years (±13). proportion smokers our 30% (89/295). Smoking significantly patient-related diagnostic delay (adjusted...
Background In 2016, the third international consensus definitions for sepsis and septic shock (Sepsis-3) task force provided revised shock. This study explores knowledge regarding among health workers in Lambaréné, Gabon. Methods We conducted a self-administered questionnaire-based survey about from referral regional hospital, research center, primary care facilities Lambaréné region. Participants were facilities. A score of one was given to each correct answer. The global out possible...
The prevalence of clinical cases pulmonary non-tuberculous mycobacteria (NTM) is increasing worldwide. aim this study was to determine the proportion and NTM species isolated from presumptive tuberculosis patients in Lambaréné, Gabon.From January 2018 December 2020, sputum samples TB were analysed at reference laboratory Centre de Recherches Médicales Lambaréné. Two collected per patient, culture performed using Bactec MGIT 960. GenoType Mycobacterium CM/AS used for isolates confirmation...
Background Infection with the filarial nematode Loa loa , endemic in Central and Western Africa, has been associated increased morbidity mortality. A number of reports described presence spleen nodules, originating from degenerating microfilariae, humans animals infected L . The long-term consequences this process on individuals chronically exposed to infection terms function possible link excess mortality are unknown. aim study was evaluate prevalence focal lesions, their evolution over...
Malaria remains a public health issue, particularly in sub-Saharan Africa with special features of seriousness young children and pregnant women. Adolescents adults are reported to have acquired semi-immune status and, therefore, present low parasitaemia. Children understood much higher parasitaemia severe malaria. It is concern that effective malaria control programmes targeting may lead delay the acquisition immunity causing shift epidemiology Prevalence were explored adolescents...
Routinely generated surveillance data are important for monitoring the effectiveness of MDR-TB control strategies. Incidence rifampicin-resistant tuberculosis (RR-TB) is a key indicator MDR-TB.In longitudinal nationwide retrospective study, 8 years (2014-2021) sputum samples from presumptively drug-resistant patients all regions Gabon were referred to national reference laboratory. Samples analysed using GeneXpert MTB/RIF and Genotype MTBDRsl version 2/Line Probe Assay.Of 3057 presumptive...