A5102990244- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Cardiac Valve Diseases and Treatments
- Orthopedic Infections and Treatments
- HIV/AIDS drug development and treatment
- Bacterial Infections and Vaccines
- HIV Research and Treatment
- Influenza Virus Research Studies
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Infectious Aortic and Vascular Conditions
- HIV-related health complications and treatments
- Clostridium difficile and Clostridium perfringens research
- Infectious Diseases and Tuberculosis
- Emergency and Acute Care Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Graphene research and applications
- Otolaryngology and Infectious Diseases
- Fiber-reinforced polymer composites
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2016-2025
Hôpital Bichat-Claude-Bernard
2016-2025
Université Paris Cité
2016-2025
Sorbonne Paris Cité
2015-2025
Centre Hospitalier Universitaire de Rennes
2021-2025
Centre d'Immunologie et des Maladies Infectieuses
2007-2025
Université Claude Bernard Lyon 1
2015-2024
Centre d'Investigation Clinique Bichat
2014-2024
Sorbonne Université
1991-2024
On Dec 31, 2019, China reported a cluster of cases pneumonia in people at Wuhan, Hubei Province. The responsible pathogen is novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the relevant features first Europe confirmed infection, disease 2019 (COVID-19), with patient diagnosed on Jan 24, 2020.In this case series, we followed five patients admitted to Bichat-Claude Bernard University Hospital (Paris, France) and Pellegrin (Bordeaux, COVID-19 by...
Observational studies showed that the profile of infective endocarditis (IE) significantly changed over past decades. However, most involved referral centers. We conducted a population-based study to control for this bias. The objective was update description characteristics IE in France and compare community-acquired versus healthcare-associated IE. A prospective observational all medical facilities from 7 French regions (32% individuals aged ≥18 years) identified 497 adults with...
To evaluate the efficacy and safety of cetuximab, a monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), as first-line monotherapy in patients with unresectable squamous cell carcinoma skin (SCCS).Thirty-six received cetuximab (initial dose 400 mg/m(2) followed by subsequent weekly doses 250 mg/m(2)) for at least 6 weeks 48-week follow-up. The primary end point was disease control rate (DCR) (according to Response Evaluation Criteria Solid Tumors [RECIST] criteria)....
Abstract The microbiology, epidemiology, diagnostics, and treatment of infective endocarditis (IE) have changed significantly since the Duke Criteria were published in 1994 modified 2000. International Society for Cardiovascular Infectious Diseases (ISCVID) convened a multidisciplinary Working Group to update diagnostic criteria IE. resulting 2023 Duke-ISCVID IE propose significant changes, including new microbiology diagnostics (enzyme immunoassay Bartonella species, polymerase chain...
<h3>Background</h3> Measurement of the degree aortic valve calcification (AVC) using electron beam computed tomography (EBCT) is an accurate and complementary method to transthoracic echocardiography (TTE) for assessment severity stenosis (AS). Whether threshold values AVC obtained with EBCT could be extrapolated multislice (MSCT) was unclear diagnostic value in patients low ejection fraction (EF) has never been specifically evaluated. <h3>Methods</h3> Patients mild severe AS underwent...
Il existe un domaine de température dans lequel la première couche d’adsorption gaz rares et méthane sur graphite passe par trois états successifs au cours sa formation. s’agit très vraisemblablement d’états « gazeux », liquide » solide bidimensionnels. y aurait donc analogie avec le cas tridimensionnel.
Rationale: Clinical decision making relative to community-acquired pneumonia (CAP) diagnosis is difficult. Chest radiograph key in establishing parenchymal lung involvement. However, radiologic performance may lead misdiagnosis, rendering questionable the use of chest computed tomography (CT) scan patients with clinically suspected CAP.Objectives: To assess whether early multidetector CT affects and management visiting emergency department CAP.Methods: A total 319 prospectively enrolled CAP...
Background: Neurologic complications of endocarditis can influence diagnosis, therapeutic plans, and prognosis. Objective: To describe how early cerebral magnetic resonance imaging (MRI) affects the diagnosis management in hospitalized adults. Design: Single-center prospective study between June 2005 October 2008. (ClinicalTrials.gov registration number: NCT00144885) Setting: Tertiary care university hospital France. Patients: 130 patients with endocarditis. Intervention: Cerebral MRI...
Background. Few studies have prospectively assessed viral etiologies of acute respiratory infections in community-based elderly individuals. We pathogens individuals ≥65 years with influenza-like illness (ILI). Methods. Multiplex reverse-transcriptase polymerase chain reaction identified nasal/throat swabs from 556 episodes moderate-to-severe ILI, defined as ILI pneumonia, hospitalization, or maximum daily influenza symptom severity score (ISS) >2. Cases were selected a randomized trial an...
Significance A detailed characterization of viral load kinetics and its association with disease evolution is key to understand the virus pathogenesis, identify high-risk patients, design better treatment strategies. We here analyze mortality virological information collected in 655 hospitalized including 284 longitudinal measurements, we build a mathematical model dynamics survival. predict that peak occurs 1 d before symptom onset, on average, decline after slower older patients. Viral...
Echocardiography plays a key role in the diagnosis of infective endocarditis (IE) but can be inconclusive patients whom prosthetic valve (PVE) is suspected. The incremental diagnostic value <sup>18</sup>F-FDG PET and radiolabeled leukocyte scintigraphy IE has already been reported. aim this study was to compare respective performance for PVE 39 patients. <b>Methods:</b><sup>18</sup>F-FDG were performed on consecutive admitted because clinically suspected echocardiography results. results...
ObjectivesIntestinal carriage with extended spectrum β-lactamase Enterobacteriaceae (ESBL-E) and carbapenemase-producing (CPE) can persist for months. We aimed to evaluate whether oral antibiotics followed by faecal microbiota transplantation (FMT) eradicate intestinal ESBL-E/CPE.MethodsRandomized, open-label, superiority trial in four tertiary-care centres (Geneva (G), Paris (P), Utrecht (U), Tel Aviv (T)). Non-immunocompromised adult patients were randomized 1: 1 either no intervention...
Immune reconstitution inflammatory syndrome (IRIS) occurred in 16 of 37 antiretroviral-naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases the CD4 cell percentage ratio cells CD8 after month antiretroviral therapy dissemination tuberculosis. These results have implications diagnosis understanding its pathogenesis.
Le graphite exfolié par dissociation thermique de son composé d'insertion avec le chlorure ferrique possède une surface d'une homogénéité exceptionnelle.
AimsThe aim of this study was to evaluate the effect valve surgery (VS) in infective endocarditis (IE) on 5-year mortality and whether conflicting results reported by previous studies could be due differences their methodological approaches.
Antibiotics are life-saving drugs but severely affect the gut microbiome with short-term consequences including diarrhea and selection of antibiotic-resistant bacteria. Long-term links to allergy obesity also suggested. We devised a product, DAV132, previously showed its ability deliver powerful adsorbent, activated charcoal, in late ileum human volunteers. performed randomized controlled trial 28 volunteers treated 5-day clinical regimen fluoroquinolone antibiotic moxifloxacin 2 parallel...