Sylvie Behillil
A5037100913- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- interferon and immune responses
- Diabetes and associated disorders
- COVID-19 and healthcare impacts
- Viral Infections and Outbreaks Research
- Animal Disease Management and Epidemiology
- Infectious Encephalopathies and Encephalitis
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Kawasaki Disease and Coronary Complications
- MicroRNA in disease regulation
- Mosquito-borne diseases and control
- Hidradenitis Suppurativa and Treatments
- Infection Control and Ventilation
- Evolution and Genetic Dynamics
- Extracellular vesicles in disease
- Immune Response and Inflammation
Centre National de la Recherche Scientifique
2013-2023
Institut Pasteur
2012-2023
Université Paris Cité
2013-2023
Department of Virology
2020-2021
Université Paris-Saclay
2021
Méditerranée Infection Foundation
2020
Aix-Marseille Université
2020
Inserm
2020
Institut de Recherche pour le Développement
2020
Centre International de Recherche en Infectiologie
2020
On Dec 31, 2019, China reported a cluster of cases pneumonia in people at Wuhan, Hubei Province. The responsible pathogen is novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the relevant features first Europe confirmed infection, disease 2019 (COVID-19), with patient diagnosed on Jan 24, 2020.In this case series, we followed five patients admitted to Bichat-Claude Bernard University Hospital (Paris, France) and Pellegrin (Bordeaux, COVID-19 by...
In the WHO European Region, COVID-19 surveillance was implemented 27 January 2020. We detail first cases. As at 21 February, nine countries reported 47 Among 38 cases studied, were linked to two clusters in Germany and France, 14 infected China. Median case age 42 years; 25 male. Late detection of clusters’ index delayed isolation further local 5 March, there 4,250
A novel coronavirus (severe acute respiratory syndrome 2, SARS-CoV-2) causing a cluster of infections (coronavirus disease 2019, COVID-19) in Wuhan, China, was identified on 7 January 2020. The epidemic quickly disseminated from Wuhan and as at 12 February 2020, 45,179 cases have been confirmed 25 countries, including 1,116 deaths. Strengthened surveillance implemented France 10 2020 order to identify imported early prevent secondary transmission. Three categories risk exposure follow-up...
Different serological assays measuring anti–SARS-CoV-2 antibodies and their neutralizing activity in samples from individuals with severe mild COVID-19 are compared.
Summary Receptor recognition is a major determinant of viral host range, infectivity and pathogenesis. Emergences have been associated with serendipitous events adaptation upon encounters novel hosts, the high mutation rate RNA viruses may explain their frequent shifts. SARS-CoV-2 extensive circulation in humans results emergence variants, including variants concern (VOCs) diverse mutations notably spike, increased transmissibility or immune escape. Here we show that, unlike initial Delta...
In May 2013, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection was diagnosed in an adult male France with severe respiratory illness, who had travelled to the United Arab Emirates before symptom onset.
Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments.To assess the efficacy and safety of a combination oral rifampin, moxifloxacin metronidazole in long-lasting refractory HS.We retrospectively studied 28 consecutive HS including 6, 10 12 Hurley stage 1, 2 3 patients, respectively. Complete remission, defined as clearance all inflammatory lesions hypertrophic scars, was main outcome criterion study.Complete...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, 2019, is responsible for the COVID-19 pandemic. It now accepted that wild fauna, probably bats, constitute initial reservoir of virus, but little known about role pets can play spread disease human communities, knowing ability SARS-CoV-2 to infect some domestic animals. In this cross-sectional study, we tested antibody response a cluster 21 (9 cats and 12 dogs) living close contact with their...
Abstract SARS-CoV-2 B.1.1.7 and B.1.351 variants emerged respectively in United Kingdom South Africa spread many countries. Here, we isolated infectious strains examined their sensitivity to anti-SARS-CoV-2 antibodies present sera nasal swabs, comparison with a D614G reference virus. We established novel rapid neutralization assay, based on reporter cells that become GFP+ after overnight infection. was neutralized by 79/83 from convalescent patients collected up 9 months post symptoms,...
COVID-19 pandemic and associated lockdown measures have deeply modified the natural course of seasonal viral infections, such as respiratory syncytial virus (RSV).We analyzed French national data from three networks: emergency departments (ED) hospitals, general practitioners (GP), hospital laboratories. We compared number ED or GP visits for bronchiolitis in children <2 years age, percentage RSV positive tests 2020 to 2021 season with those two previous seasons (2018-2019 2019-2020). used...
Abstract It is of paramount importance to evaluate the prevalence both asymptomatic and symptomatic cases SARS-CoV-2 infection their antibody response profile. Here, we performed a pilot study assess levels anti-SARS-CoV-2 antibodies in samples taken from 491 pre-epidemic individuals, 51 patients Hôpital Bichat (Paris), 209 pauci-symptomatic individuals French Oise region 200 contemporary blood donors. Two in-house ELISA assays, that recognize full-length nucleoprotein (N) or trimeric Spike...
The emergence of SARS-CoV-2 variant 20I/501Y.V1 (VOC-202012/1 or GR/501Y.V1) is concerning given its increased transmissibility. We reanalysed 11,916 PCR-positive tests (41% all positive tests) performed on 7-8 January 2021 in France. prevalence was 3.3% among nationwide and 6.9% the Paris region. Analysing recent rise 20I/501Y.V1, we estimate that, French context, 52-69% more transmissible than previously circulating lineages, depending modelling assumptions.
Abstract Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a lineage - designated B.1.620 Lithuania and carrying many mutations deletions spike protein shared with widespread variants of concern (VOCs), including E484K, S477N HV69Δ, Y144Δ, LLA241/243Δ. As well as documenting suite this carries, we also its potential to be resistant...
We aimed to investigate the first Omicron cases detected in France order assess case characteristics and provide supporting information on possible impact of this variant healthcare system. A standardized questionnaire was used collect from confirmed probable cases. Median age 468 investigated 35 years, 376 were symptomatic (89%); 64% vaccinated with two doses 7% had received three doses. Loss smell taste reported by 8.3% 9% cases, respectively. Seven hospitalized, those unvaccinated...
Memory B-cell and antibody responses to the SARS-CoV-2 spike protein contribute long-term immune protection against severe COVID-19, which can also be prevented by antibody-based interventions. Here, wide immunoprofiling in Wuhan COVID-19 convalescents combining serological, cellular, monoclonal explorations revealed humoral immunity coordination. Detailed characterization of a hundred memory antibodies uncovered diversity their repertoire antiviral functions. The latter were influenced...
International case definitions recommended by the Centers for Disease Control and Prevention (CDC), European Centre (ECDC), World Health Organization (WHO) are commonly used influenza surveillance. We evaluated clinical factors associated with laboratory-confirmed diagnosis of performance these using a complete dataset 14,994 patients acute respiratory infection (ARI) from whom specimen was collected between August 2009 April 2014 Groupes Régionaux d’Observation de la Grippe (GROG), French...
Following SARS-CoV-2 emergence in China, a specific surveillance was implemented France. Phylogenetic analysis of sequences retrieved through this suggests that detected initial introductions, involving non-clade G viruses, did not seed local transmission. Nevertheless, identification clade variants subsequently circulating the country, with earliest from patient who neither travelled to risk areas nor had contact travellers, might have been present before first recorded cases.
Several French regions where coronavirus disease (COVID-19) has been reported currently show a renewed increase in ILI cases the general practice-based Sentinelles network. We computed number of excess by region from 24 February to 8 March 2020 and found correlation with COVID-19 so far. The data suggest larger circulation severe acute respiratory syndrome 2 (SARS-CoV-2) population than apparent confirmed cases.
Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics 31 cynomolgus macaques for which nasopharyngeal and tracheal load were frequently assessed. We identified that cells had large burst size (>10 4 virus) within-host reproductive basic number of approximately 6 compartment, respectively. After peak load, rapidly lost half-life 9 hours, no significant association between cytokine elevation...
SARS-CoV-2 infection results in impaired interferon response patients with severe COVID-19. However, how interferes host immune responses is incompletely understood. Here, we sequence small RNAs from SARS-CoV-2-infected human cells and identify a microRNA (miRNA) derived recently evolved region of the viral genome. We show that virus-derived miRNA produces two isoforms infected by enzyme Dicer, which are loaded into Argonaute proteins. Moreover, predominant isoform targets 3'UTR...
<title>Abstract</title> Recombination is a crucial process in the evolution of many organisms. Although evolutionary reasons behind its occurrence RNA viruses are debated, this phenomenon has been associated with major epidemiological events such as virus host range expansion, antigenic shift or variation virulence 1,2, and occurs frequently positive strand coronaviruses. The SARS-CoV-2 pandemic repeated emergence variants concern presenting increased transmissibility, severity immune escape...
Abstract Following the emergence of coronavirus disease (COVID-19) in Wuhan, China December 2019, specific COVID-19 surveillance was launched France on January 10, 2020. Two weeks later, first three imported cases into Europe were diagnosed France. We sequenced 97 severe acute respiratory syndrome 2 (SARS-CoV-2) genomes from samples collected between 24 and March 24, 2020 infected patients Phylogenetic analysis identified several early independent SARS-CoV-2 introductions without local...