Carine Roy
A5111074193- COVID-19 Clinical Research Studies
- Rheumatoid Arthritis Research and Therapies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- Connective tissue disorders research
- Pelvic floor disorders treatments
- Malaria Research and Control
- Bacterial Infections and Vaccines
- Spondyloarthritis Studies and Treatments
- Parasites and Host Interactions
- Aortic Disease and Treatment Approaches
- COVID-19 and healthcare impacts
- Pneumonia and Respiratory Infections
- Intensive Care Unit Cognitive Disorders
- Lipoproteins and Cardiovascular Health
- Total Knee Arthroplasty Outcomes
- Meta-analysis and systematic reviews
- Diabetes and associated disorders
- Statistical Methods in Clinical Trials
- Lymphoma Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Clinical practice guidelines implementation
- Autoimmune and Inflammatory Disorders Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
Université Claude Bernard Lyon 1
2010-2024
Inserm
2013-2024
Hôpital Bichat-Claude-Bernard
2014-2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Hospital Universitario Infanta Leonor
2023-2024
Banaras Hindu University
2024
Methodist Hospital
2023
All India Institute of Medical Sciences Raipur
2023
All India Institute of Medical Sciences Rishikesh
2023
Université Paris Cité
2006-2022
TGFBR2 mutations were recognized recently among patients with a Marfan-like phenotype. The associated clinical and prognostic spectra remain unclear.Clinical features outcomes of 71 mutation (TGFBR2 group) compared 50 age- sex-matched unaffected family members (control subjects) 243 harboring FBN1 (FBN1 group). Aortic dilatation was present in similar proportion both the groups (78% versus 79%, respectively) but highly variable. incidence average age for thoracic aortic surgery (31% 27%...
Optimal management, including timing of surgery, remains debated in Marfan syndrome because a lack data on aortic risk associated with this disease.We used our database to evaluate standardized care. Patients who fulfilled the international criteria, had not previous surgery or dissection, and came center at least twice were included. Aortic measurements made echocardiography (every 2 years); patients given systematic β-blockade advice about sports activities. Prophylactic was proposed when...
Large studies on severe imported malaria in non-endemic industrialized countries are lacking. We sought to describe the clinical spectrum of French adults and identify risk factors for mortality at admission intensive care unit.Retrospective review Plasmodium falciparum episodes according 2000 World Health Organization definition requiring unit. Data were collected from medical charts using standardised case-report forms, 45 units 2000-2006. Risk in-hospital identified by univariate...
9001 Background: The risk of treatment-related toxicity increases with age and may even lead to toxic death. Comprehensive Geriatric Assessment (CGA) is an appropriate but time-consuming method. development a screening tool appears adequate. Based on multicenter prospective cohort 364 cancer patients > 70, we developed the G8 (8 items; range 0 [poor] 17 [good prognosis]). Results suggested 14 as threshold, equivalent 90% sensitivity, 60% specificity. Methods: We have set up national study...
Atherogenic dyslipidemia is associated with poor cardiovascular outcomes, yet markers of this condition are often ignored in clinical practice. Here, we address a clear evidence gap by assessing the prevalence and treatment two atherogenic dyslipidemia: elevated triglyceride levels low high-density lipoprotein cholesterol. This cross-sectional observational study assessed markers, high cholesterol levels, population from European Study on Cardiovascular Risk Prevention Management Usual Daily...
Memory B-cell and antibody responses to the SARS-CoV-2 spike protein contribute long-term immune protection against severe COVID-19, which can also be prevented by antibody-based interventions. Here, wide immunoprofiling in Wuhan COVID-19 convalescents combining serological, cellular, monoclonal explorations revealed humoral immunity coordination. Detailed characterization of a hundred memory antibodies uncovered diversity their repertoire antiviral functions. The latter were influenced...
BackgroundIn patients with noncirrhotic chronic portal vein thrombosis (PVT), the benefit of long-term anticoagulation is unknown. We assessed effects rivaroxaban on risk venous thromboembolism and hypertension-related bleeding in such patients.MethodsIn this multicenter, controlled trial, we randomly assigned PVT without major factors for to receive either 15 mg/day or no anticoagulation. The primary end point was 2-year thrombosis-free survival. Secondary points included occurrence...
The vast majority of ICU patients require some form venous access. There are no evidenced-based guidelines concerning the use either central or peripheral catheters, despite very different complications. It remains unknown which to insert in patients. We investigated rate catheter-related insertion maintenance complications two strategies: one favoring catheters and other catheters.Multicenter, controlled, parallel-group, open-label randomized trial.Three French ICUs.Adult with equal access...
Transcatheter arterial chemoembolisation (TACE) has been reported to be an efficient treatment of liver metastases endocrine tumours in short series patients. However, several factors seem affect its results. The aim this work is identify predictors response TACE for tumours. A total 163 procedures were performed 67 patients between 1994 and 2004. Forty-four treated with streptozotocin 23 doxorubicin. Primary tumour was located the pancreas 19 patients, had removed 43. Thirty-eight...
Objective To evaluate the impact of standardised consultations on patients with osteoarthritis knee. Design Open pragmatic cluster randomised controlled trial. Setting Primary care in France. Participants 198 primary rheumatologists, each whom had to include two consecutive who met American College Rheumatology criteria for Interventions Standardised consultation was provided during three goal oriented visits (education and treatment management; information physical exercises; weight loss)...
Abstract Little is known on the association between clinical factors and coronavirus disease 2019 (COVID‐19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID‐19 hospitalized patients to describe clinical, biological, virological characteristics at hospital admission over time, according mortality up Day 60 admission. For analysis risk survival, analyses assessing associations demographic or comorbidities were performed using Cox regression model....
Abstract Background Humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs within the first weeks after disease 2019 (COVID-19). Those antibodies exert a neutralizing activity against SARS-CoV-2, whose evolution over time COVID-19 as well efficiency novel variants are poorly characterized. Methods In this prospective study, sera of 107 patients hospitalized with were collected at 3 and 6 months postinfection. We performed quantitative neutralization...
Elevated C-reactive protein (CRP) levels are associated with high cardiovascular risk, and might identify patients who could benefit from more carefully adapted risk factor management. We have assessed the prevalence of elevated CRP in one or traditional factors. Data were analysed European Study on Cardiovascular Risk Prevention Management Usual Daily Practice (EURIKA, ClinicalTrials.gov Identifier: NCT00882336 ), which included (aged ≥50 years) 12 countries at least but no history disease....
It is well established that fat distribution rather than the total quantity of major determinant cardiovascular risk in overweight subjects. However, it not known whether concept still makes sense severely obese Particularly, role visceral accumulation and/or adipocyte hypertrophy insulin resistance (IR) has been studied this population. Therefore, aim study was to clarify determinants metabolic disorders women. We performed a cross-sectional 237 women (BMI >35 kg/m(2)). assessed body mass...