A5063959627- Malaria Research and Control
- Mosquito-borne diseases and control
- Dermatological diseases and infestations
- Research on Leishmaniasis Studies
- Drug-Induced Hepatotoxicity and Protection
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Travel-related health issues
- Computational Drug Discovery Methods
- Insects and Parasite Interactions
- Allergic Rhinitis and Sensitization
- Study of Mite Species
- Vector-borne infectious diseases
- Hepatitis C virus research
- Complement system in diseases
- Drug Transport and Resistance Mechanisms
- Insect Pest Control Strategies
- Helminth infection and control
- Insect and Pesticide Research
- Bird parasitology and diseases
- HIV/AIDS drug development and treatment
- Bartonella species infections research
- Leptospirosis research and findings
- Photoreceptor and optogenetics research
- Zoonotic diseases and public health
Université Paris-Saclay
2007-2025
Centre National de la Recherche Scientifique
2022-2025
Assistance Publique – Hôpitaux de Paris
2011-2024
Centre Hospitalier Universitaire Henri-Mondor
2024
Laboratoire des Biomolécules
2019-2022
Hôpital Avicenne
2010-2020
Université Sorbonne Paris Nord
2006-2020
Méditerranée Infection Foundation
2020
Université Paris Cité
1997-2015
Johns Hopkins University
2015
Little is known about severe imported malaria in nonendemic industrialized countries. The purpose of this retrospective study was to describe the clinical spectrum adults and determine factors that were present at admission associated with in-intensive care unit mortality. This evaluated 188 patients who admitted our intensive 1988-1999 and/or complicated malaria. Among them, 93 had strictly defined malaria, 95 less mean age 38 years, 51% nonimmune whites, 94% acquired Plasmodium falciparum...
Large studies on severe imported malaria in non-endemic industrialized countries are lacking. We sought to describe the clinical spectrum of French adults and identify risk factors for mortality at admission intensive care unit.Retrospective review Plasmodium falciparum episodes according 2000 World Health Organization definition requiring unit. Data were collected from medical charts using standardised case-report forms, 45 units 2000-2006. Risk in-hospital identified by univariate...
Background Plasmodium vivax is the most prevalent human malaria parasite, causing serious public health problems in malaria-endemic countries. Until recently Duffy-negative blood group phenotype was considered to confer resistance for African ethnicities. We and others have reported that P. strains countries from Madagascar Mauritania display capacity cause clinical people. New insights must now explain Duffy-independent invasion of erythrocytes. Methods/Principal Findings Through recent...
The purpose of this prospective study was to update epidemiological data on cutaneous larva migrans (CLM) and assess the therapeutic efficacy ivermectin. We performed between June 1994 December 1998 at our travel clinic. Ivermectin (a single dose 200 microg/kg) offered all patients with CLM, its tolerability were assessed by a questionnaire. Sixty-four enrolled. All European had stayed in tropical areas. After returned from their destinations, 55% lesions occur within mean 16 days (range,...
ABSTRACT The parasitic loads of mouse livers experimentally infected with Leishmania infantum were determined using a double real-time quantitative PCR test targeted to the parasite DNA polymerase gene and brain-derived neutrophic factor gene. copy number was normalized copies in order quantify former independently liver weight. correlation coefficient microtitration method 0.66. This assay can be considered for experimental pharmaceutical studies.
Plasmodium falciparum malaria is a serious health hazard for travelers to malaria-endemic areas and often diagnosed on return the country of residence. We conducted retrospective study imported among returning France from 1996 through 2003. Epidemiologic, clinical, parasitologic data were collected by network 120 laboratories. Factors associated with fatal identified logistic regression analysis. During period, 21,888 cases reported. There 96 deaths, case-fatality rate 4.4 per 1,000 malaria....
Abstract Little is known about severe imported Plasmodium falciparum malaria in industrialized countries where the disease not endemic because most studies have been case reports or included <200 patients. To identify factors independently associated with severity of P. falciparum, we conducted a retrospective study using surveillance data obtained from 21,888 patients France during 1996–2003; 832 were classified as having malaria. The global case-fatality rate was 0.4% and ≈3.8%. Factors...
The development of alternative approaches in ectoparasite management is currently required. Essential oils have been demonstrated to exhibit fumigant and topical toxicity a number arthropods. aim the present study was assess potential efficacy ten essential against Sarcoptes scabiei. major chemical components were identified by GC-MS analysis. Contact fumigation bioassays performed on mites collected from experimentally infected pigs. For contact bioassays, diluted with paraffin get...
Among populations living in areas endemic for malaria, repeated parasite exposure leads to a gradual increase protective immunity the disease. In contrast, this is assumed disappear after several years of non-exposure. This study was designed investigate long-term subjects removed from risk exposure. Plasmodium falciparum malaria attacks occurring short trips sub-Saharan Africa were compared between 99 European patients and 252 African immigrants who had been resident Europe at least four...
We have developed a new fragment-analysis method to enumerate the clones and quantify their proportions within Plasmodium falciparum isolates. prospectively enrolled 20 adult patients with uncomplicated malaria who were returning France from various sub-Saharan countries, January 2000 through July 2001. The analysis of clonal populations was performed on blood samples obtained at 10 times: 1 before treatment oral quinine 9 during first 96 h treatment. resistance genotypes pfcrt dhfr...
Because of its dramatic public health impact, Plasmodium falciparum resistance to chloroquine (CQ) has been documented early on. Chloroquine-resistance (CQR) emerged in the late 1950's independently South East Asia and America progressively spread over all malaria areas. CQR was reported Africa 1970's, since invaded African continent. Many questions remain about actual selection spreading process parasites, evolution ancestral mutant gene(s) during spreading. Eleven clinical isolates P. from...
The head louse, Pediculus humanus capitis (De Geer), is an hematophagous ectoparasite that affects mainly children. Resistance to insecticides belonging pyrethroids and other pediculicides, such as malathion, responsible for frequently reported treatment failures. Recent studies showed a M815I-T929I-L932F kdr-like mutation in the voltage-gated sodium channel alpha-subunit gene was associated with permethrin resistance lice from several countries worldwide. We searched presence ofpyrethroid...
ABSTRACT The aim of this study was to provide the first comprehensive spatiotemporal picture Plasmodium falciparum resistance in various geographic areas Madagascar. Additional data about antimalarial neighboring islands Comoros archipelago were also collected. We assessed prevalence pfcrt , pfmdr-1 pfdhfr and pfdhps mutations gene copy number 1,596 P. isolates collected 26 health centers (20 Madagascar 6 Islands) from 2006 2008. vitro responses a panel drugs by 373 parasite determined....
Inadequate treatment practices with antimalarials are considered major contributors to Plasmodium falciparum resistance chloroquine, pyrimethamine and sulfadoxine. The longitudinal survey conducted in Dielmo, a rural Senegalese community, offers unique frame explore the impact of strictly controlled quantified antimalarial use for diagnosed malaria on drug resistance.We yearly basis retrospective over ten-year period that included two successive policies, namely quinine during 1990-1994,...