A5005361633- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Plant Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Hepatitis B Virus Studies
- Vector-Borne Animal Diseases
- Hepatitis C virus research
- SARS-CoV-2 detection and testing
- Virology and Viral Diseases
- Bacteriophages and microbial interactions
- Respiratory viral infections research
- Insect and Pesticide Research
- Scientific Computing and Data Management
- Hepatitis Viruses Studies and Epidemiology
- Insect symbiosis and bacterial influences
- Animal Virus Infections Studies
- Evolution and Genetic Dynamics
- Infection Control and Ventilation
- Tea Polyphenols and Effects
- Yersinia bacterium, plague, ectoparasites research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Plant and Fungal Interactions Research
- Liver Disease Diagnosis and Treatment
- Physiological and biochemical adaptations
Robert Koch Institute
2022-2025
Charité - Universitätsmedizin Berlin
2019-2024
European Centre for Disease Prevention and Control
2024
Freie Universität Berlin
2020-2022
Humboldt-Universität zu Berlin
2020-2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2019
The spectrum of viruses in insects is important for subjects as diverse public health, veterinary medicine, food production, and biodiversity conservation. traditional interest vector-borne diseases humans livestock has drawn the attention virus studies to hematophagous insect species. However, these represent only a tiny fraction broad diversity Hexapoda, most speciose group animals. Here, we systematically probed negative strand RNA largest representative collection transcriptomes from...
Abstract Since the onset of pandemic, many SARS-CoV-2 variants have emerged, exhibiting substantial evolution in virus’ spike protein 1 , main target neutralizing antibodies 2 . A plausible hypothesis proposes that virus evolves to evade antibody-mediated neutralization (vaccine- or infection-induced) maximize its ability infect an immunologically experienced population 1,3 Because viral infection induces antibodies, may thus navigate on a dynamic immune landscape is shaped by local history....
Abstract Insects are the most diversified and species-rich group of animals harbor an immense diversity viruses. Several taxa in flavi-like superfamily, such as genus Flavivirus, associated with insects; however, systematic studies on insect virus genetic lacking, limiting our understanding evolution superfamily. Here, we examined viruses within complete up-to-date transcriptome collection comprising 1,243 species by employing a Flaviviridae RdRp profile hidden Markov model search. We...
Significance Hepatitis delta virus (HDV) aggravates hepatitis B (HBV) infection of liver cells. Although the viruses are evolutionarily unrelated, HDV depends on HBV because it requires envelope protein for its transmission. is only described in humans, which has triggered diverse hypotheses regarding evolution and origins. Here we show that spiny rats ( Proechimys semispinosus ) carry a counterpart to surprisingly does not cause linked HBV. The rodent deltavirus finding alone, but also...
Crimean–Congo haemorrhagic fever virus (CCHFV) is the medically most important member of rapidly expanding bunyaviral family Nairoviridae . Traditionally, CCHFV isolates have been assigned to six distinct genotypes. Here, International Committee on Taxonomy Viruses (ICTV) Study Group outlines reasons for recent decision re-classify genogroup VI (aka Europe-2 or AP-92-like) as a virus, Aigai (AIGV).
<title>Abstract</title> Recombination is a crucial process in the evolution of many organisms. Although evolutionary reasons behind its occurrence RNA viruses are debated, this phenomenon has been associated with major epidemiological events such as virus host range expansion, antigenic shift or variation virulence 1,2, and occurs frequently positive strand coronaviruses. The SARS-CoV-2 pandemic repeated emergence variants concern presenting increased transmissibility, severity immune escape...
Kolmioviridae is a family for negative-sense RNA viruses with circular, viroid-like genomes of about 1.5–1.7 kb that are maintained in mammals, amphibians, birds, fish, insects and reptiles. Deltaviruses, instance, can cause severe hepatitis humans. Kolmiovirids encode delta antigen (DAg) replicate using host-cell DNA-directed polymerase II ribozymes encoded their genome antigenome. They require evolutionary unrelated helper to provide envelopes incorporate virus proteins infectious particle...
Abstract Background Comprehensive pathogen genomic surveillance represents a powerful tool to complement and advance precision vaccinology. The emergence of the Alpha variant in December 2020 resulting efforts track spread this other severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants concern led an expansion sequencing activities Germany. Methods At Robert Koch Institute (RKI), German National Public Health, we established Integrated Molecular Surveillance for SARS-CoV-2...
Jingchuvirales is an order of negative-sense RNA viruses with genomes 9.1–15.3 kb that have been associated arachnids, barnacles, crustaceans, insects, fish and reptiles in Africa, Asia, Australia, Europe, North America South America. The jingchuviral genome has two to four open reading frames (ORFs) encode a glycoprotein (GP), nucleoprotein (NP), large (L) protein containing RNA-directed polymerase (RdRP) domain, and/or proteins unknown function. Viruses the are only known from their...
The rapid evolution of respiratory viruses is characterized by the emergence variants with concerning phenotypes that are efficient in antibody escape or show high transmissibility. This necessitates timely identification such surveillance networks to assist public health interventions. Here, we introduce VirusWarn, a comprehensive system designed for detecting, prioritizing, and warning emerging virus from large genomic datasets. VirusWarn uses both manually-curated rules machine-learning...
The genus Phlebovirus (order Bunyavirales , family Phenuiviridae ) comprises 57 viruses that are grouped into nine species-complexes. Sandfly-transmitted phleboviruses found in Europe, Africa and the Americas responsible for febrile illness infections of nervous system humans. aim this study was to assess genetic diversity sandfly-transmitted connected isolated forest habitats throughout Panama Canal area Central Panama. In total, we collected 13 807 sandflies comprising eight phlebotomine...
Xinmoviridae is a family of viruses with negative-sense RNA genomes 9-14 kilobases. Xinmovirids typically infect beneficial and pest insects but their host range has not yet been investigated systematically hence may be broader. This summary the International Committee on Taxonomy Viruses (ICTV) Report Xinmoviridae, which available at ictv.global/report/xinmoviridae.
Members of the family Lispiviridae are viruses with negative-sense RNA genomes 6.5–15.5 kb that have mainly been found in arthropods and nematodes. The lispivirids contain several open reading frames, typically encoding a nucleoprotein (N), glycoprotein (G), large protein (L) including an RNA-directed polymerase (RdRP) domain. This is summary International Committee on Taxonomy Viruses (ICTV) Report , which available at ictv.global/report/lispiviridae .
To examine the risk associated with bus riding and identify transmission chains, we investigated a COVID-19 outbreak in Germany 2021 that involved index case-patients among bus-riding students. We used routine surveillance data, performed laboratory analyses, interviewed case-patients, conducted cohort study. identified 191 65 (34%) of whom were elementary schoolchildren. A phylogenetically unique strain epidemiologic analyses provided link between air travelers cases company staff,...
ABSTRACTGlobal and even national genome surveillance approaches do not provide the resolution necessary for rapid accurate direct response by local public health authorities. Hence, a regional network of microbiological laboratories in collaboration with departments all districts German federal state Mecklenburg-Western Pomerania (M-V) was formed to investigate molecular epidemiology circulating SARS-CoV-2 lineages between 11/2020 03/2022. More than 4750 samples from M-V counties were...
Nyamiviridae is a family of viruses in the order Mononegavirales , with unsegmented (except for members genus Tapwovirus ), negative-sense RNA genomes 10–13 kb. Nyamviruses have genome organisation and content similar to that other mononegaviruses. includes several genera form monophyletic clades on phylogenetic analysis polymerase. Nyamiviruses been found associated diverse invertebrates as well land- seabirds. Members Nyavirus Socyvirus produce enveloped, spherical virions. This summary...
Abstract Since the onset of pandemic, many SARS-CoV-2 variants have emerged, exhibiting substantial evolution in virus spike protein, main target neutralizing antibodies. A plausible hypothesis proposes that evolves to evade antibody-mediated neutralization (vaccine- or infection-induced) maximize its ability infect an immunologically experienced population. While infection induces antibodies, viral may thus navigate on a dynamic immune landscape resulted from history different regions....
The International Virus Bioinformatics Meeting 2020 was originally planned to take place in Bern, Switzerland, March 2020. However, the COVID-19 pandemic put a spoke wheel of almost all conferences be held After moving conference 8–9 October 2020, we got hit by second wave and finally decided at short notice go fully online. On other hand, has made us even more aware importance accelerating research viral bioinformatics. Advances bioinformatics have led improved approaches investigate...
The identification of genomic variants has become a routine task in the thriving age genome sequencing. Particularly small single or few nucleotides are routinely investigated for their impact on an organism’s phenotype. Hence, precise and robust detection variants’ exact location change nucleotide composition is vital many biological applications. Although plethora methods exist key steps variant detection, thoroughly testing process evaluating its results still cumbersome procedure. In...
The identification of genomic variants has become a routine task in the age genome sequencing. In particular, small single or few nucleotides are routinely investigated for their impact on an organism's phenotype. Hence, precise and robust detection variants' exact locations changes nucleotide composition is vital many biological applications. Although plethora methods exist key steps variant detection, thoroughly testing process evaluating its results still cumbersome procedure. this work,...