A5022526235- Poxvirus research and outbreaks
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Bacillus and Francisella bacterial research
- SARS-CoV-2 and COVID-19 Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Virus-based gene therapy research
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
- Immunotherapy and Immune Responses
- Bacteriophages and microbial interactions
- Mosquito-borne diseases and control
- Toxin Mechanisms and Immunotoxins
- vaccines and immunoinformatics approaches
- RNA and protein synthesis mechanisms
- Viral Infections and Immunology Research
- Viral Infections and Outbreaks Research
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Insect and Pesticide Research
- Hepatitis B Virus Studies
- Animal Disease Management and Epidemiology
State Research Center of Virology and Biotechnology VECTOR
2014-2023
Genetic Technologies (Australia)
2020-2023
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2020-2023
Novosibirsk Tuberculosis Research Institute
2020
Federal Agency for Scientific Organizations
2017
Russian Academy of Sciences
2012
In the WHO European Region, COVID-19 surveillance was implemented 27 January 2020. We detail first cases. As at 21 February, nine countries reported 47 Among 38 cases studied, were linked to two clusters in Germany and France, 14 infected China. Median case age 42 years; 25 male. Late detection of clusters’ index delayed isolation further local 5 March, there 4,250
This study presents the isolation of influenza A(H5N8) virus clade 2.3.4.4b from a poultry worker during an outbreak highly pathogenic avian among chickens at farm in Astrakhan, Russia December 2020. Nasopharyngeal swabs collected seven workers were positive for A(H5N8), as confirmed by RT-PCR and sequencing. The was isolated one human specimens characterised. Sporadic A(H5)2.3.4.4. infections represent possible concern public health.
Vaccination of the population is one most effective countermeasures in responding to pandemic caused by novel coronavirus infection. Therefore, scientists all over world have been working develop and safe vaccines. We developed a synthetic peptide vaccine, EpiVacCorona, against SARS-CoV-2 coronavirus, which suspension for intramuscular administration containing composition chemically synthesized immunogens S protein conjugated carrier adsorbed on aluminum hydroxide. Phase I–II clinical...
Background. The ongoing pandemic of a new coronavirus infection (COVID-19) determines the relevance analysis epidemiological patterns SARS-CoV-2 spread among population Russian Federation.Aim — study manifestations epidemic process COVID-19 in Federation 2020–2022.Materials and methods. A retrospective incidence was carried out from 03/30/2020 to 04/24/2022. data Rospotrebnadzor report No. 970 “Information on cases infectious diseases persons with suspected infection”, information portal...
Background. The ongoing pandemic of the novel coronavirus infection (COVID-19) draws attention to significance molecular and genetic monitoring SARS-CoV-2 spread among population Russian Federation. aim study was analyze dynamics circulation variants in Russia.Materials methods. analysis for Russia carried out, covering period from 28/12/2020 26/6/2022. included data Rospotrebnadzor Report No. 970 "Information about Infectious Diseases Individuals with Suspected Novel Coronavirus Infection"...
To date, the 'one bug-one drug' approach to antiviral drug development cannot effectively respond constant threat posed by an increasing diversity of viruses causing outbreaks viral infections that turn out be pathogenic for humans. Evidently, there is urgent need new strategies develop efficient agents with broad-spectrum activities. In this paper, we identified camphene derivatives showed broad activities in vitro against a panel enveloped viruses, including influenza virus A/PR/8/34...
Background: In 2020, the pandemic caused by novel coronavirus infection has become one of most critical global health challenges during past century. The lack a vaccine, as effective way to control infection, prompted development large number preventive products scientific community. We have developed candidate vaccine (EpiVacCorona) against SARS-CoV-2 that is based on chemically synthesized peptides conjugated carrier protein and adsorbed aluminum hydroxide studied specific activity...
In the present work we studied antiviral activity of home library monoterpenoid derivatives using pseudoviral systems our development, which have glycoproteins SARS-CoV-2 virus strains Wuhan and Delta on their surface. We found that borneol with a tertiary nitrogen atom can exhibit at early stages viral replication. order to search for potential binding sites ligands glycoprotein, carried out additional biological tests study inhibition re-receptor-binding domain protein S. For compounds...
The State Research Center of Virology and Biotechnology "VECTOR" the Federal Service for Oversight Consumer Protection Welfare (Rospotrebnadzor) has developed peptide-based EpiVacCorona vaccine, which is first synthetic antiviral vaccine mass immunization in international vaccinology. An early clinical trial (Phase I-II) demonstrated that a safe product. "Multicenter double-blind, placebo-controlled, comparative, randomized to assess tolerability, safety, immunogenicity prophylactic efficacy...
In this study, we investigated the features of infectious process by simulating co-infection with SARS-CoV-2 and human adenovirus type 5 (HAdV-5) or influenza A virus (IAV) in vitro vivo. The determination activity viruses digital PCR demonstrated that during simultaneous sequential HAdV-5 followed infection vivo, does not interfere replication SARS-CoV-2. hamsters co-infected mono-infected exhibited nearly identical viral titers loads lungs. ferrets SARS-CoV-2- IAV more pronounced clinical...
The first example of adamantane derivatives containing monoterpene moieties that showed inhibitory activity against several orthopoxviruses.
When developing drugs against SARS-CoV-2, it is important to consider the characteristics of patients with different co-morbidities. People infected HIV-1 are a particularly vulnerable group, as they may be at higher risk than general population contracting COVID-19 clinical complications. For such patients, broad spectrum antiviral activity paramount importance. Glycyrrhizinic acid (Glyc) and its derivatives promising biologically active compounds for development broad-spectrum agents. In...
Since most of the modern human population has no anti-smallpox immunity, it is extremely important to develop and implement effective drugs for treatment smallpox other orthopoxvirus infections. The objective this study determine main characteristics chemical substance NIOCH-14 its safety bioavailability in body laboratory animals.The upon single- or multiple-dose intragastric administration was assessed according effect on hematological pathomorphological parameters mice rats. In order...
In order to test the antiviral activity, a series of usnic acid derivatives were synthesized, including new, previously undescribed compounds. The activity against three strains SARS-CoV-2 virus was studied. To understand mechanism action, inhibitory main protease studied using developed model as well pseudoviral system with glycoprotein S on its surface. It shown that exhibits virus: Wuhan, Delta, and Omicron. Compounds 10 13 also showed high strains. performed biological studies molecular...
Despite the fact that variola virus is considered eradicated, search for new small molecules with activity against orthopoxviruses remains an important task, especially in context of recent outbreaks monkeypox. As a result this work, number amides benzoic acids containing adamantane fragment were obtained. Most compounds demonstrated vaccinia virus, selectivity index SI = 18,214 leader compound 18a. The obtained derivatives also murine pox (250 ≤ 6071) and cowpox (125 3036). A correlation...
This paper describes the current situation on highly pathogenic avian influenza virus in 2022 and provides forecast of possible further spread Russia. In 2022, circulation a wide variety subtypes, which have epizootiological epidemiological significance, was recorded world. Outbreaks caused by were reported over 60 countries. addition, human infections with viruses A(H5Nx) A(H9N2) subtypes registered. There large-scale epizootic affected more than 10 regions European part Russia Russian Far...
A successful HIV vaccine in addition to induction of antibody responses should elicit effective T cell responses. Here we described possible strategies for rational design T-cell capable induce high levels both CD4+ and CD8+ T- We developed artificial HIV-1 polyepitope immunogens based on the conserved natural epitopes from different strains restricted by most frequent major human leukocyte antigen (HLA) alleles. Designed contain optimized core sequence additional "signal" sequences which...