A5071408406- Healthcare Systems and Public Health
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Human Health and Disease
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- COVID-19 epidemiological studies
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Hepatitis Viruses Studies and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Animal Virus Infections Studies
- CRISPR and Genetic Engineering
- Pneumonia and Respiratory Infections
- Bacterial biofilms and quorum sensing
- Antibiotic Use and Resistance
- Salmonella and Campylobacter epidemiology
- Vector-borne infectious diseases
- COVID-19 Pandemic Impacts
Central Research Institute of Epidemiology
2014-2025
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2015-2025
North-Western State Medical University named after I.I. Mechnikov
2025
Central Research Institute
2020-2024
Centers for Disease Control and Prevention
2023
National Center for Emerging and Zoonotic Infectious Diseases
2023
Russian Academy of Sciences
2019-2021
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
2021
Perm State University
2021
Republican Scientific and Practical Center of Cardiology
2021
An epidemic of COVID-19 (Coronavirus disease 2019) etiologically associated with the SARS-CoV-2 (Severe acute respiratory syndrome-related coronavirus 2) that occurred at turn 2019–2020 firstly in Wuhan (Hubei province China) and then spread to many countries around world rose a new wave interest coronaviruses. The first coronaviruses – members Coronaviridae family belonging order Nidovirales — were discovered half last century. human coronavirus, HCoV-B814, was isolated 1965 not preserved...
Background. The ongoing pandemic of a new coronavirus infection (COVID-19) determines the relevance analysis epidemiological patterns SARS-CoV-2 spread among population Russian Federation.Aim — study manifestations epidemic process COVID-19 in Federation 2020–2022.Materials and methods. A retrospective incidence was carried out from 03/30/2020 to 04/24/2022. data Rospotrebnadzor report No. 970 “Information on cases infectious diseases persons with suspected infection”, information portal...
Klebsiella pneumoniae, which is frequently associated with hospital- and community-acquired infections, contains multidrug-resistant (MDR), hypervirulent (hv), non-MDR/non-hv as well convergent representatives. It known that mostly international high-risk clonal lineages including sequence types (ST) 11, 147, 258, 307 drive their global spread. ST395, was first reported in the context of a carbapenemase-associated outbreak France 2010, less well-characterized, yet emerging lineage.
Acinetobacter baumannii is an opportunistic pathogen being one of the most important causative agents a wide range nosocomial infections associated with multidrug resistance and high mortality rate. This study presents multiparametric correlation analyses clinical multidrug-resistant A. isolates using short- long-read whole-genome sequencing, which allowed us to reveal specific characteristics different CRISPR/Cas systems. We also compared antibiotic virulence gene acquisition for groups...
Abstract Background The dual infection with SARS-CoV-2 is poorly described and currently under discussion. We present a study of two strains detected in the same patient during disease presentation. Case presentation A their 90 s was hospitalised fever. Oropharyngeal swab obtained on next day (sample 1) tested positive for SARS-CoV-2. Five days later, transferred to ICU (intensive care unit) hospital specialising treatment COVID-19 patients, where patient's condition progressively worsened...
Background. The ongoing pandemic of the novel coronavirus infection (COVID-19) draws attention to significance molecular and genetic monitoring SARS-CoV-2 spread among population Russian Federation. aim study was analyze dynamics circulation variants in Russia.Materials methods. analysis for Russia carried out, covering period from 28/12/2020 26/6/2022. included data Rospotrebnadzor Report No. 970 "Information about Infectious Diseases Individuals with Suspected Novel Coronavirus Infection"...
Delta has outcompeted most preexisting variants of SARS-CoV-2, becoming the globally predominant lineage by mid-2021. Its subsequent evolution led to emergence multiple sublineages, which are well-mixed between countries. By contrast, here we show that nearly entire epidemic in Russia probably descended from a single import event, or closely timed imports poorly sampled geographic location. Indeed, over 90 per cent samples characterized nsp2:K81N + ORF7a:P45L pair mutations is rare outside...
The topic of epidemiologic surveillance is one the basic concepts in theory and practice science. In Russia, generalization accumulated factual material theoretical developments have allowed us to formulate a number provisions on nature epidemic process. pandemic new coronavirus infection has forced adjustments all spheres society, including activities infectious disease epidemiological system, requiring development implementation innovative solutions. Based experience prompt response tasks...
Relevance . Hepatitis B virus (HBV) is the etiologic agent of acute and chronic hepatitis in humans. WHO recommends use sensitive laboratory assays based on nucleic acid amplification methods to detect HBV DNA. A method for detecting single copies DNA using CRISPR/Cas systems was previously developed ultrasensitive detection Aims The aim present study optimize systems. Materials To obtain amplified fragments genome, 22 oligonucleotides were developed. preliminary stage performed by RPA...
Klebsiella pneumoniae is one of the most important pathogens concerned with multidrug resistance in healthcare-associated infections. The treating infections caused by this bacterium complicated due to emergence and rapid spreading carbapenem-resistant strains, which are associated high mortality rates. Recently, several hypervirulent carbapenemase-producing isolates were reported that make situation even more complicated. In order better understand virulence mechanisms, and, turn, develop...
In 2021, a patient died from Marburg virus (MARV) disease in Guinea and it was the first confirmed case West Africa. The origin of outbreak has not been identified. It revealed that didn't travel anywhere before illness. Prior to outbreak, MARV had found bats neighboring Sierra Leone, but never Guinea. Therefore, infection is unclear: an autochthonous with spillover local population or imported fruit foraging/migrating Leone? this paper, we studied Rousettus aegyptiacus as possible source...
The COVID-19 pandemic, etiologically related to a new coronavirus, has had catastrophic impact on the demographic situation global scale. aim of this study was analyze manifestations epidemic process, dynamics circulation, and rate spread variants SARS-CoV-2 virus in Russian Federation. Retrospective epidemiological analysis incidence from March 2020 fall 2023 molecular genetic monitoring variability using next-generation sequencing technologies bioinformatics methods were performed. Two...
Introduction. Since the outbreak of COVID-19 pandemic caused by SARS-CoV-2 novel coronavirus, international community has been concerned about emergence mutations altering some biological properties pathogen like increasing its infectivity or virulence. Particularly, since end 2020, several variants concern have identified around world, including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2). However, existing mechanism detecting important are not always effective...
Acinetobacter baumannii is a dangerous bacterial pathogen possessing the ability to persist on various surfaces, especially in clinical settings, and rapidly acquire resistance broad spectrum of antibiotics. Thus, epidemiological surveillance A. within particular hospital, region, across world an important healthcare task that currently usually includes performing whole-genome sequencing (WGS) representative isolates. During past years, dissemination was mainly driven by strains belonging...
Background. The COVID-19 pandemic has exposed health problems, but at the same time become a powerful impetus for development of new scientific research in field epidemiology, clinic infectious diseases, diagnostics, bioinformatics and digital methods. On basis Central Research Institute Epidemiology Rospotrebnadzor, unique test systems detection SARS-CoV-2 RNA based on real-time PCR loop isothermal amplification (IT) technology have been developed, which allows you to examine samples 34...
We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial phase I/II tolerability, safety, and immunogenicity inactivated whole virion concentrated purified coronavirus vaccine CoviVac in volunteers aged 18-60 open comparative IIb 60 years older. The safety was assessed 400 age cohort who received two doses (n = 300) or placebo 100) 200 60+ all whom three vaccine. studied has shown good tolerability safety. No deaths, serious adverse events (AEs),...
The Doctrine for the prevention of health с are-associated Infections (HAIs) is a declaration state policy in field epidemiological safety medical care. This system views and provisions that establishes direction HAIs, ways forms their implementation. presence deeply developed doctrine makes it possible to have basis decision-making. According conclusion experts from World Health Organization, no type healthcare settings any country can claim be free risk HAIs. Four key underpin risk-based...
Multidrug resistance (MDR) and hypervirulence (hv) have been long considered distinct evolutionary traits for Klebsiella pneumoniae (Kp), a versatile human pathogen. The recent emergence of Kp strains combining these poses serious global threat. In this article, we describe the phenotypic genomic characteristics an MDR hvKp isolate, MAR14-456, representative nosocomial outbreak in Moscow, Russia, that was recovered from postoperative wound patient who later developed multiple abscesses,...
The purpose of the study is to analyze patterns demonstrated by COVID-19 epidemic process in a megacity during increase, stabilization and reduction incidence, evaluate effectiveness prevention measures.Materials methods. comprehensive incorporating epidemiological, molecular genetic statistical research methods was conducted spread SARS-CoV-2 Moscow COVID- 19 pandemic.Results discussion. It found that exponential growth cases prevented due most stringent control restrictive measures...
Background.The COVID-19 epidemic in the Russian Federation, which began March 2020, caused serious damage to health of population and led severe economic losses. By December 28, 3 078 035 cases 55 265 lethal outcomes were registered country. The all territorial subjects country is involved process COVID-19. epidemiological situation made it necessary conduct an analysis identify factors that determine high intensity process, as well groups with highest risk SARS-CoV-2 infection.
 Aims...
Annualy, SARS occupy a leading position in terms of morbidity and the magnitude economic damage caused both world Russian Federation. Currently, most widespread pandemics are by influenza A (H1N1) pdm09 virus new SARS-CoV-2 coronavirus, which common ecological niche require studying manifestations epidemic process ARVI for further development measures to improve epidemiological surveillance this group infections. Aim study was investigate current influenza, including context coronavirus...
Relevance . Despite the successes achieved over 85-year history of study tick-borne encephalitis (TBE), there are still many controversial and unresolved issues. It is obvious that in second decade XXI century, this natural focal neuroinfection, as before, poses a great threat to public health not only Russia, but also endemic countries world. Aim To present modern aspects etiology, epidemiology, diagnosis, specific prevention TBE Russia Conclusions Currently, 4 genotypes virus: Far Eastern,...