A5020068758- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Respiratory viral infections research
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Tuberculosis Research and Epidemiology
- Plant Virus Research Studies
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- vaccines and immunoinformatics approaches
- Vector-Borne Animal Diseases
- Insect and Pesticide Research
- Viral Infections and Outbreaks Research
- Bacteriophages and microbial interactions
- Tryptophan and brain disorders
- DNA and Nucleic Acid Chemistry
- Skin Protection and Aging
- Animal Disease Management and Epidemiology
- HIV/AIDS drug development and treatment
- Photodynamic Therapy Research Studies
- Engineering and Environmental Studies
Russian Academy of Sciences
2021-2024
Chumakov Institute of Poliomyelitis and Viral Encephalitides
2015-2024
Biological E (India)
2023
Centre for Research and Development
2021-2022
Effective response to emerging pandemic threats is complicated by the need develop specific vaccines and other medical products. The availability of broadly countermeasures that could be deployed early in significantly alter its course save countless lives. Live attenuated (LAVs) were shown induce non-specific protection against a broad spectrum off-target pathogens stimulating innate immune responses. purpose this study was evaluate effect immunization with bivalent Oral Poliovirus Vaccine...
We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial phase I/II tolerability, safety, and immunogenicity inactivated whole virion concentrated purified coronavirus vaccine CoviVac in volunteers aged 18-60 open comparative IIb 60 years older. The safety was assessed 400 age cohort who received two doses (n = 300) or placebo 100) 200 60+ all whom three vaccine. studied has shown good tolerability safety. No deaths, serious adverse events (AEs),...
The widespread use of the oral poliovaccine from Sabin strains (tOPV) radically reduced poliomyelitis incidence worldwide. However, OPV became a source neurovirulent vaccine-derived polioviruses (VDPVs). Currently, circulating type 2 VDPVs (cVDPV2) are leading cause poliomyelitis. novel vaccine (nOPV2), based on genetically modified strain with increased genetic stability and risk cVDPV formation, has been used to combat cVDPV2 outbreaks, including one in Tajikistan 2021. In order identify...
In August 2022, in the Moscow region, Russia, on a backyard farm, mortality was observed at chickens and all 45 birds of this farm died or were slaughtered after onset symptoms within few days. Paramyxovirus isolated from diseased birds. Based nucleotide sequences F NP gene fragments, belonging virus to subgenotype VII.1 AAvV-1 class II established. The cleavage site 109SGGRRQKRFIG119 T 546 555 position gene, typical for velogenic type. genetically closest NDV isolates found Iran. mean time...
In August 2022 on a backyard farm in the Moscow region of Russia, mortality was observed among chickens, and all 45 birds particular died or were slaughtered after onset symptoms within few days. Paramyxovirus isolated from diseased birds. Based nucleotide sequences F NP gene fragments, it determined that virus belonged to subgenotype VII.1 AAvV-1 class II. The cleavage site 109SGGRRQKRFIG119 T 546 555 position typical for velogenic type. genetically closest NDV isolates found Iran. mean...
More than 100 types of non-polio enteroviruses (NPEVs) are ubiquitous in the human population and cause a variety symptoms ranging from very mild to meningitis acute flaccid paralysis (AFP). Much information regarding diverse pathogenic properties NPEVs comes surveillance poliovirus, which also yields NPEV. The analysis 265 NPEV isolations 10,433 AFP cases over 24 years more 2500 findings patients without severe neurological lesions suggests that EV-A71, E13, E25 were significantly...
Surveillance for acute flaccid paralysis syndrome (AFP) in children under 15 is the backbone of Global Polio Eradication Initiative. Laboratory examination stool samples from AFP cases allows detection of, along with polioviruses, a variety non-polio enteroviruses (NPEV). The etiological significance these viruses occurrence has been definitively established only A71 and D68. Enterovirus Coxsackie A2 (CVA2) most often associated vesicular pharyngitis hand, foot mouth disease. Among 7280...
ABSTRACT We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial tolerability, safety, and immunogenicity inactivated whole virion concentrated purified coronavirus vaccine CoviVac in adult volunteers aged 18-60. Safety was assessed 398 who received two doses (n=298) or placebo (n=100). The studied has shown good tolerability safety. No deaths, serious adverse events (AE), other significant AE related to vaccination have been detected. most...
Swine vesicular disease virus (SVDV) emerged around 1960 from a human enterovirus ancestor, coxsackievirus B5 (CVB5), and caused series of epizootics in Europe Asia. We characterized B4 strain that an epizootic involving 24 488 pigs the Soviet Union 1975. Phylogenetic evidence suggested swine ancestor between 1945 1975, almost simultaneously with transfer CVB5.
Green fluorescent protein (GFP) chromophore and its congeners draw significant attention mostly for bioimaging purposes. In this work we probed these compounds as antiviral agents. We have chosen LTR-III DNA G4, the major G-quadruplex (G4) present in long terminal repeat (LTR) promoter region of human immunodeficiency virus-1 (HIV-1), target primary screening designing drug candidates. The stabilization G4 was previously shown to suppress viral gene expression replication. FRET-based...
Abstract Evolutionary potential of viruses can result in outbreaks well‐known and emergence novel ones. Pharmacological methods intervening the reproduction various less popular, but not important are available, as well spectrum antiviral activity for most known compounds. In framework chemical biology paradigm, characterization new compounds allows to extend space provides structure–activity relationships data‐driven drug discovery. Here we present a primary assessment spiro‐annulated...
SARS-CoV-2 has been actively circulating in the human population since late 2019. During this time, virus acquired more than 140 nucleotide mutations and 20 deletions per genome from original variant identified Wuhan. As circulates, proportion of re-infected individuals increases, but it is unclear how well neutralizing antibodies formed by infection with early variants neutralize new Omicron lines. We analyzed activity 286 sera adult patients COVID-19 2020-2021, during circulation...
The detection of a vaccine-derived poliovirus (VDPV) requires an epidemiological assessment and response. Using repeated stool sampling from child who is immunocompetent was vaccinated against poliomyelitis with acute flaccid paralysis, case extremely rapid evolution Sabin-like (PV) type 3 traced in the child's body.The independently identified two countries-Tajikistan Russia. Stool samples for study were also collected countries on different days onset paralysis. Virological, serological,...
Rose Bengal (RB) is an anionic xanthene dye with multiple useful biological features, including photosensitization properties. RB was studied extensively as a photosensitizer, mostly for antibacterial and antitumor photodynamic therapy (PDT). The application of to virus inactivation rather understudied, no derivatives have been developed antivirals. In this work, we used synthetic approach based on successful design photosensitizing antivirals produce photoinactivation. A series...
Abstract Vaccines are proven to be an effective tool in prophylaxis of severe COVID-19, but emerging mutated SARS-CoV-2 variants constantly challenge vaccines’ protectivity. We have evaluated the ability sera from individuals vaccinated with two inactivated vaccine CoviVac and COVID-19 convalescents (May-December 2020) neutralize Delta Omicron. Four groups serum samples (CoviVac vaccinees; convalescents; mice immunized preparations based on prototype B.1.1 strain variant) were virus...
COVID-19 is a systemic inflammatory disease initiated by SARS-CoV-2 virus infection. Multiple vaccines against the Wuhan variant of have been developed including whole virion beta-propiolactone-inactivated vaccine based on B.1.1 strain (CoviVac). Since most population has vaccinated targeting original or early variants SARS-CoV-2, emergence novel mutant raises concern over possible evasion vaccine-induced immune responses. Here, we report mechanism protection CoviVac, virion-based vaccine,...
The pandemic caused by the novel betacoronavirus SARS-CoV-2 has already claimed more than 3.5 million lives. Despite development and use of anti-COVID-19 vaccines, disease remains a major public health challenge throughout world. Large-scale screening drugs approved for treatment other viral, bacterial, parasitic infections, as well autoimmune, oncological, diseases is currently underway part their repurposing effective therapeutic agents against SARS-CoV-2. In this work, we present results...
The article presents the results of a study regulatory framework and experience regulating issues reclamation developed space leading coal mining countries - United States China. laws China on mineral resources environmental protection, US practice creating system for restoring disturbed as result mining, are examined
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Non-polio enteroviruses obtained in 2023 from patients with meningitis were studied. Virus types identified: CVB5, CVB4, E6, E7, E11, E18, E30; for the most frequently occurring ones (CVB5, E30), phylogenetic analysis was carried out.
Scientific relevance. Innate immune activation in the early phases of COVID-19 infection and subsequent interferon induction may help control viral replication protect cells not yet infected with SARS-CoV-2. Thus, immunostimulants that induce (IFN), including double-stranded RNA-based agents, are a promising means post-exposure prophylaxis treatment at stages. Aim. The study evaluated vitro antiviral activity RNA sodium salt-based medicinal product against Materials methods. authors analysed...