A5079420851- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Silk-based biomaterials and applications
- Asthma and respiratory diseases
- Systemic Lupus Erythematosus Research
- Carbohydrate Chemistry and Synthesis
- NF-κB Signaling Pathways
- Wound Healing and Treatments
- Inflammasome and immune disorders
- Gut microbiota and health
- Pediatric health and respiratory diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mycobacterium research and diagnosis
- Legume Nitrogen Fixing Symbiosis
- Glycosylation and Glycoproteins Research
- Long-Term Effects of COVID-19
Sirius University of Science and Technology
2021-2024
Engelhardt Institute of Molecular Biology
2015-2024
Lomonosov Moscow State University
2006-2024
Genetic Technologies (Australia)
2023
Moscow State University
2000-2017
Russian Academy of Sciences
2011
In-Q-Tel
2010
National Medical Research Center for Hematology
2001
National Cancer Institute
1998
Genesis Laboratories
1998
Abstract Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF cells, leading to telogen–anagen transition (TAT) around the wound and de novo regeneration, mostly through TNF signalling. Both knockout overexpression attenuate neogenesis wounds, suggesting dose-dependent induction by TNF, which is consistent with TNF-induced AKT signalling vitro . β-catenin...
Significance In spite of TNF involvement in the pathogenesis multiple sclerosis (MS), systemic neutralization MS patients was not successful. One possible reasons is that possesses both pathogenic and protective features may be related to TNFR1 versus TNFR2 receptor engagement. This study uncovers one such functions mediated by intrinsic signaling T reg cells. mice bearing humanized genetic loci, ablation restricted cells led reduced capacity control Th17 cell responses, exacerbated...
Asthma is a common inflammatory disease of the airway caused by combination genetic and environmental factors characterized airflow obstruction, wheezing, eosinophilia neutrophilia lungs sputum. Similar to other proinflammatory cytokines, IL-6 elevated in asthma plays an active role this disease. However, exact molecular mechanism involvement pathogenesis remains largely unknown major cellular source pathogenic has not been defined. In present study, we used conditional gene targeting...
Overexpression of TNF contributes to pathogenesis multiple autoimmune diseases, accounting for a remarkable success anti-TNF therapy. is produced by variety cell types, and it can play either beneficial or deleterious role. In particular, in autoimmunity pathogenic may be derived from restricted cellular sources. this study we evaluated the feasibility cell-type-restricted inhibition vivo. To end, engineered MYSTI (Myeloid-Specific Inhibitor)--a recombinant bispecific antibody that binds...
Akkermansia muciniphila is a gram-negative anaerobic bacterium, which represents part of the commensal human microbiota. Decline in abundance A. among other microbial species gut correlates with severe systemic diseases such as diabetes, obesity, intestinal inflammation and colorectal cancer. Due to its mucin-reducing immunomodulatory properties, use probiotics containing sp. appears promising approach treatment metabolic inflammatory diseases. In particular, number studies have focused on...
We generated a novel tumor necrosis factor (TNF) null mutation using Cre-loxP technology. Mice homozygous for this differ from their "conventional" counterparts; in particular, they completely lack Peyer's patches (PP) but retain all lymph nodes. Our analysis of these TNF-knockout mice supports the previously disputed notion involvement TNF-TNFR1 signaling PP organogenesis. Availability strains both with and without enables more definitive studies concerning roles TNF various immune...
Toll-like receptor 4 (TLR4) is required for activation of innate immunity upon recognition lipopolysaccharide (LPS) Gram-negative bacteria. The ability TLR4 to respond a particular LPS species important since insufficient may not prevent bacterial growth while excessive immune reaction lead immunopathology associated with sepsis. Here we investigated the biological activity from Burkholderia mallei that causes glanders, and two well-known opportunistic pathogens Acinetobacter baumannii...
Three-dimensional (3D) silk fibroin scaffolds were modified with one of the major bone tissue derivatives (nano-hydroxyapatite) and/or a collagen derivative (gelatin). Adhesion and proliferation mouse embryonic fibroblasts (MEF) within scaffold increased after modification either nano-hydroxyapatite or gelatin. However, significant increase in MEF adhesion was observed when both additives introduced into scaffold. Such composite provide new better platform to study wound healing, other...
Despite decades of research the goal achieving scarless wound healing remains elusive. One approaches, treatment with polymeric microcarriers, was shown to promote tissue regeneration in various vitro models healing. The vivo effects such an approach are attributed transferred cells microparticles functioning merely as inert scaffolds. We aimed establish a bioactive biopolymer carrier that would and inhibit scar formation murine model deep skin wounds. Here we characterize two candidate...
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid (IMCs) that, under normal conditions, may differentiate into mature macrophages, granulocytes, and dendritic cells. However, pathological conditions associated with inflammation, cancer, or infection, such differentiation is inhibited leading to IMC expansion. Under the influence inflammatory cytokines, these become MDSCs, acquire immunosuppressive phenotype, accumulate in affected tissue, as...
Objectives Neutralisation of tumour necrosis factor (TNF) is widely used as a therapy for rheumatoid arthritis (RA). However, this only effective in less than half patients and associated with several side effects. We hypothesised that TNF may possess non-redundant protective immunomodulatory functions vivo cannot be blocked without cost. The present work aimed to identify cellular sources pathogenic TNF, its molecular forms during autoimmune arthritis. Methods Mice lacking expression by...
Combined anti-cytokine therapy is a promising therapeutic approach for uncontrolled steroid-resistant asthma. In this regard, simultaneous blockade of IL-4 and IL-13 signaling by Dupilumab (anti-IL-4Ra monoclonal antibody) was recently approved severe eosinophilic However, no options neutrophilic asthma are currently available. Recent advances in our understanding pathogenesis suggest that both IL-6 TNF may represent potential targets treatment Nevertheless, the efficacy pharmacological...
Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, is accompanied a dysregulated immune response. In particular, NK cells, involved in antiviral response, are affected infection. This study aimed to investigate circulating cells with focus on their activation, depletion, changes surface expression of key receptors, and functional activity during COVID-19, among intensive care unit (ICU) patients, moderately ill convalescents (CCP). Our data confirmed that cell activation...