A5031377014- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Electrochemical Analysis and Applications
- CAR-T cell therapy research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biomedical and Engineering Education
- Atherosclerosis and Cardiovascular Diseases
- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- COVID-19 and Mental Health
- Neuroscience and Neural Engineering
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
Federal Medical-Biological Agency
2023-2024
Medical Technologies (Czechia)
2023
Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, is accompanied a dysregulated immune response. In particular, NK cells, involved in antiviral response, are affected infection. This study aimed to investigate circulating cells with focus on their activation, depletion, changes surface expression of key receptors, and functional activity during COVID-19, among intensive care unit (ICU) patients, moderately ill convalescents (CCP). Our data confirmed that cell activation...
The study investigated the electrical characteristics of Caco-2 cellular layer grown on a cellulose acetate membrane using impedance spectroscopy and cyclic voltammetry methods. effect ethanol solutions varying concentrations electrophysical properties was studied. During measurements by method under direct current, it found that its resistance before treatment 642 kOhm. Treatment with 25% solution increased this value to 645 kOhm, while 50% 95% decreased 505 kOhm 373 respectively. layer's...
Lung-on-a-Chip (LoC) is a microfluidic device that simulates the gas-liquid interface of human pulmonary alveoli and intended for pathophysiological, pharmacological molecular biological studies blood-air barrier in vitro. The LoC includes system liquid gas microchannels separated by semipermeable elastic membrane containing polymer base cellular elements alveoli. Depending on type (single-channel, two-channel three-channel), may contain only alveolocytes, or alveolocytes combination with...
Introduction . Lung cancer is the leading cause of mortality in men and women. Due to its high prevalence significant recurrence rate after standard therapy, search for new methods lung treating an urgent task. A promising treatment strategy immunotherapy that elicit immune response against tumor cells. Objective Evaluation clinical efficacy prospects safe use malignant neoplasms pleural cavity. Discussion The introduction immunotherapeutic approaches, including adoptive cell therapy with...
Ischemic stroke is a global medical problem and one of the leading causes death or disability worldwide. The main approach ischemic therapy in most acute period, which can prevent minimize development neurological deficit, restoration blood flow brain tissue using enzymatic thrombolysis endovascular thromboextraction. When therapeutic window missed, modulation inflammatory response may play an important role determining fate neurons penumbra. key players this process are T-regulatory cells...