Based on the available publications, article systematizes forms of damage to central nervous system in СOVID-19patients. Along with a description clinical manifestations, pathogenesis, methods laboratory, instrumental and radiological diagnosis discussion nosological forms. An interdisciplinary approach international cooperation are required study problems course, outcomes, development new treatment.

The article highlights the pathogenesis, clinical manifestations of lesions central and peripheral nervous system that have arisen or persist in patients postcoid period (Long-COVID-19). Their correct assessment, use effective methods complex treatment, targeted neurorehabilitation contribute to reversibility functional disorders, prevention, reduction disability, improvement quality life indicators, prevention progression cognitive, emotional, behavioral disorders initiated by SARS-CoV-2.

The own observation of the patient and literature data on epidemiology, etiology, pathogenesis schizencephaly development, diagnostic methods are presented. peculiarity presented case is rarity this malformation belonging to cortical dysgenesis. results demonstrate child’s ability acquire motor skills in absence epileptic seizures characteristic malformation, which gives a chance for rehabilitation measures improvement quality life.

Despite the success of modern conservative therapy severe spinal instability, surgical methods still retain their importance in treatment this pathology, but even most successful operation may be vain without subsequent adequate rehabilitation. This report summarizes features rehabilitation patients after surgery for injuries cervical spine using and means physiofunctional treatment.

The review systematizes data on the role of infectious diseases and systemic inflammation in pathogenesis stroke. Various risk factors for stroke associated with pro-inflammatory reactions their contribution to cerebrovascular pathology are analyzed. interaction hemostasis disturbances clots formation, activation autoreactive clones cytotoxic lymphocytes, progression endothelial damage, other processes is shown. Along infection, these increase key mechanisms from development acute or chronic...

The article covers the pathogenesis, clinical manifestations, and diagnostic criteria of frailty senile apathy in elderly. Special attention is paid to sarcopenia: phenotypic classification modern approaches treatment are discussed. knowledge understanding main pathogenetic links sarcopenia, apathy, as well development a single therapeutic line for these pathological conditions can significantly improve life quality expectancy

Involutionary forms of muscle pathology for the neurological community is ‘terra incognita’. The purpose this publication to describe clinical forms, pathogenesis, diagnostic and treatment methods skeletal diseases in aging population.

This review summarizes current understanding of the interaction between circadian rhythms gene expression and epigenetic clocks characterized by specific profile DNA methylation in CpG-islands which mirror chronological age individual cells entire organism. Basic mechanisms regulation for genes CLOCK- BMAL1 as well downstream clock-controlled (ССG) are also discussed here. It has been shown that operate finely tuned transcription rely on various including activation enhancers / suppressors,...

Speech system is a widely spread and complexly organized of human brain. Lately new data on morphology, brain cortex functioning neuroplasticity speech have been obtained by using contemporary imaging techniques. Using functional MRI positron emission tomography (PET) we revealed favorable patterns for recovery damaged system. The base network realizes through activating perilesional zones tertiary associative cortex of the dominant hemisphere. The role right hemispheric homologues areas in...

Modern surgery is constantly developing and enhancing methods of preventing curing hernias in various areas the human body. The relevance work based on continuous improvement techniques surgical interventions for etiologies. scientific significance consists determining main literature information statistical data encountered recent years, as well identifying novel effective prophylaxis cure this pathology. Materials methods. Various statistics years were analyzed. It has been found out that...

Sarcopenia, asthenia, and motor activity restriction are common among geriatric patients in the post-COVID period. The SARS-CoV-2 virus triggers a cytokine storm human body induces direct viral effect on skeletal muscles. Manifestations of post-acute sequelae COVID-19 (PASC) can include organ system dysfunction, muscle weakness, dyspnea, chest pain, cognitive impairment, depression, anxiety, sleep disorders. Hypoxemia, comorbidity, prolonged inactivity contribute to changes structure...

The field of research on ferroptosis has seen an explosive growth in the past few years since term was coined 2012. This review highlights current state knowledge developmental mechanism this unique mode cell death, induced by iron-dependent phospholipid peroxidation, which is regulated a variety cellular metabolic events, including redox homeostasis. xCT system, amino acid antiporter that supports synthesis glutathione (GSH) and oxidation protection, among these factors. risk iron...

A comprehensive examination and dynamic observation of a patient with clinical manifestations connective tissue dysplasia dissection the internal carotid arteries revealed symptom complex characteristic Harlequin syndrome. The description this form pathology is given for first time in national literature. brief review presents diagnostic criteria mechanisms development rare autonomic dysfunction.

The diagnosis of acute stroke should be correct and early that allows physician planning the most effective treatment strategies (reperfusion therapy, undifferentiated (basic) treatment, secondary prevention). However, symptoms can atypical similar to some other (non-vascular) event. It significantly complicate clinical decrease patient's chances for treatment. A suspected in every patient with onset neurological symptoms, especially when has 'vascular' risk factors. Furthermore it is...

The article describes the clinical manifestations of dural arteriovenous fistula, which is an abnormal communication between arteries dura mater and venous sinuses or cortical veins. Information on etiology pathogenesis such malformation in domestic literature limited to a few publications. Diagnosis based identification visual (pulsation earlobe) acoustic phenomena patient, presence neuroimaging, particular MR angiography, shunt posterior auricular artery (branch external carotid artery)...

Introduction.Malformations of ecto- and mesodermal structures represent various forms abnormality intrauterine systemic local morphogenesis, arising at different times embryonic development due to environmental factors, genomic, chromosomal or gene mutations. Dysregulation cellular functions mutations accumulation defective proteins initiates tumor transformation tissues e.g. hereditary diseases ectomesodermal origin phakomatosis (hamartomatosis).
 The aim the studywas determine organ...

From year to year, postoperative pain syndrome following a surgical intervention on the cervical and lumbar regions of spine becomes an increasingly serious problem for surgeons. The treatment such pathology requires multidisciplinary approach. Drug therapy does not always provide desired outcome. Non-drug approaches, as neuromodulation with surgically implanted spinal cord stimulator or non-invasive transcutaneous electrical nerve stimulation, are currently in great demand. However, given...

Ischemic stroke is a global medical problem and one of the leading causes death or disability worldwide. The main approach ischemic therapy in most acute period, which can prevent minimize development neurological deficit, restoration blood flow brain tissue using enzymatic thrombolysis endovascular thromboextraction. When therapeutic window missed, modulation inflammatory response may play an important role determining fate neurons penumbra. key players this process are T-regulatory cells...