A5017626731- Immunodeficiency and Autoimmune Disorders
- Bacterial Infections and Vaccines
- Human Health and Disease
- Pediatric health and respiratory diseases
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Immune responses and vaccinations
- Vaccine Coverage and Hesitancy
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Gut microbiota and health
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Blood disorders and treatments
- Clostridium difficile and Clostridium perfringens research
- Hepatitis B Virus Studies
- Healthcare Systems and Public Health
- Respiratory viral infections research
- Ultrasound in Clinical Applications
- Intramuscular injections and effects
- Neonatal Respiratory Health Research
- Neonatal skin health care
- Advanced Thermodynamic Systems and Engines
- vaccines and immunoinformatics approaches
- Infections and bacterial resistance
Tyumen State Medical University
2009-2024
The State Research Center of Virology and Biotechnology "VECTOR" the Federal Service for Oversight Consumer Protection Welfare (Rospotrebnadzor) has developed peptide-based EpiVacCorona vaccine, which is first synthetic antiviral vaccine mass immunization in international vaccinology. An early clinical trial (Phase I-II) demonstrated that a safe product. "Multicenter double-blind, placebo-controlled, comparative, randomized to assess tolerability, safety, immunogenicity prophylactic efficacy...
Primary immunodeficiencies (PID) are a group of rare genetic disorders with multitude clinical symptoms. Characterization epidemiological and data via national registries has proven to be valuable tool studying these diseases. Materials Methods. The Russian PID registry was set up in 2017, by the National Association Experts (NAEPID). It is secure, internet-based database that includes detailed clinical, laboratory therapeutic on patients all ages. Results. contained information 2728 (60%...
The heavy burden of meningococcal infection is associated not only with life-threatening complications in the acute period and high mortality invasive forms disease, but also severe consequences survivors, who are recorded our country.The aim study: to analyze clinical manifestations, outcomes disease children various regions Russian Federation.Materials methods: an analysis data from 1327 inpatient medical records 14 regional centers Federation for 2012-2021 was carried out (28.3% cases...
Background. One of the effective ways to maintain epidemic well-being vaccine preventable diseases is estimate immunization rates and coverage. Objective. The aim study conduct comparative analysis levels among children in various regions Russian Federation. Methods. Children aged from 6 months 15 years conducted indicators documented coverage according forms 112/y 036/y four federal districts rate was estimated individuals who had completed vaccination scheme national schedule (NIS) (of...
Background. Monitoring of documented vaccination is one the indicators epidemiological supervision quality preventive vaccination. It crucial for epidemical situation prevention. Objective. The aim study to estimate immunization and coverage levels according National Immunization Schedule (NIS) children population in Russia. Methods. rates were estimated cards (form №063/y) development №112/y) among aged from 6 months 15 years 8 towns was determined by ratio people who has fully performed...
Pneumococcal infections are among the most common an important cause of morbidity and mortality worldwide, including Russia. At end 2014 in national immunization schedule countries introduced vaccination against pneumococcal infection The aim study. To assess epidemiological effectiveness young children selectively different territories Russian Federation 2 years later from its beginning Materials methods. In course observational analytical research type «case-control» data were obtained on...
The appearance of new high-tech microbiological research methods has significantly changed the understanding human microbiome. purpose meeting Council Experts "Dysbiosis. immediate and long-term consequences microbiome disorders options for their correction with probiotics" was definition modern positions about possible studying intestinal microbiome, possibilities correcting dysbiosis, use Saccharomyces Boulardii CNCM I-745 to correct in various clinical situations. microbiota large...
The incidence of acute intestinal infections in Russia is ranked 3rd 4th among all infectious diseases, and rotavirus the most frequent etiologic factor children under 5 years old. Almost 40% age two have three episodes infection, same group undergo severe course disease. Rotavirus gastroenteritis causes 197,000 annual deaths, 23 die due to this infection every hour. high resistance environment, ease transmission large number asymptomatic carriers predetermine need for timely vaccination....
The article presents the results of a clinical investigation on administration Grippol Quadrivalent vaccine (influenza tetravalent inactivated subunit adjuvant vaccine) in children from 6 months to 5 years old. has demonstrated no less effectiveness comparison with plus trivalent polymer-subunit vaccine).comparable were obtained for all evaluated indicators immunological efficacy against matching strains influenza virus, while additional strain B (Yamagata line) there was statistically...
КОНЦЕНТРАЦИЯ МАТРИКСНЫХ МЕТАЛЛОПРОТЕИНАЗ-2,9 У НОВОРОЖДЕННЫХ С ПЕРИНАТАЛЬНОЙ ГИПОКСИЕЙ Малинина Е.И. 1 , Чернышева Т
The article presents data on the features of COVID-19 infection in patients with primary immunodeficiencies (PIDs) Russian Federation, obtained through National association experts PID (NAEPID) registry. Materials and methods: from March 1, 2020 to October 15, 2020, 15 cases close intrafamilial contact between PIDs without reliable first 23 were reported. Results: 6/23 infected people had asymptomatic course infection, 9/23 – mild form, 8/23 moderate form disease, one patient a severe fatal...
According to the data from Russian primary immunodeficiencies (PID) registry 71% of registered patients were treated with immunoglobulins (IG). Regular immunoglobulin substitutions reported in 90% antibody deficiencies (PAD), 86% - syndromic PID and 91% combined T B cell defects. The study was supported by Academic Council Dmitry Rogachev National Medical Center Pediatric Hematology, Oncology Immunology approved Local Ethical Committee within registry. IG substitution analyzed representative...
Background . Acrodermatitis enteropathica is the rare form of inherited dermatoses. The disease onset in children associated with ablactation and beginning cow milk products use, that makes differential diagnosis acrodermatitis allergic dermatoses pretty difficult. caution specialists to hypozincemia at periorificial dermatitis combined alopecia diarrhea infants will allow establish correct choose management timely. Clinical Case Description clinical case erosive- desquamative presented this...
The appearance of new high-tech microbiological research methods has significantly changed the understanding human microbiome. purpose meeting Council Experts Dysbiosis. immediate and long-term consequences microbiome disorders options for their correction with probiotics was definition modern positions about possible studying intestinal microbiome, possibilities correcting dysbiosis, use Saccharomyces boulardii CNCM I-745 to correct in various clinical situations. criteria norm have not...
В научной литературе недостаточно информации об особенностях иммунологических сдвигов у детей с учетом критических периодов формирования иммунной системы.Инфекционный мононуклеоз (ИМ) при первичной Эпштейна-Барр вирусной инфекции (пЭБВИ) благоприятным течением характеризуется в остром периоде повышением содержания CD3 + , CD4 CD8 CD16 HLA-DR CD95 CD20 -Лф, сывороточных иммуноглобулинов и провоспалительных цитокинов.При манифестной реактивации ЭБВИ (рЭБВИ) происходит разбалансировка...
Relevance . The need to create a domestic pneumococcal polyvalent vaccine is one of the main directions «Strategy for development prevention infectious diseases period up 2035». Aim To evaluate immunological efficacy and safety polysaccharide conjugate adsorbed thirteen-valent (PCV13) in immunization adults children theRussian Federation. Materials methods conjugated were studied prospective comparative randomized double-blind study parallel groups adult volunteers aged 18 65 years...
The myocardial infarction is considered to be an adult disease. Therefore, many pediatricians pay little attention this problem. electrocardiographic changes in children characteristic of can the signs other pathology. article describes four clinical cases various nosologies accompanied by ST-segment elevation: a bridge, Kawasaki syndrome, abnormal discharge left coronary artery, postoperative complication after surgical treatment congenital heart diseases. authors discuss difficulties...
The biological fertility potential in mothers of late reproductive age is limited by the natural decline and infertility. Despite significant success introduction new diagnostic therapeutic technologies into clinical practice, problem childlessness far from being finally resolved. health status children born after use assisted another open issue. up-to-date data on adverse effects vitro fertilization (IVF) do not have adequate substantiation, since external parental factors cannot be...