A5024161412- Venomous Animal Envenomation and Studies
- Malaria Research and Control
- Mosquito-borne diseases and control
- Rabies epidemiology and control
- Hemoglobinopathies and Related Disorders
- Marine Invertebrate Physiology and Ecology
- Neonatal Health and Biochemistry
- COVID-19 Clinical Research Studies
- Amphibian and Reptile Biology
- Trypanosoma species research and implications
- Insect and Pesticide Research
- Research on Leishmaniasis Studies
- Long-Term Effects of COVID-19
- Healthcare and Venom Research
- Vector-borne infectious diseases
- Methemoglobinemia and Tumor Lysis Syndrome
- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Parasites and Host Interactions
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Yersinia bacterium, plague, ectoparasites research
- Infectious Encephalopathies and Encephalitis
- Drug-Induced Hepatotoxicity and Protection
- Child Nutrition and Water Access
Fundação de Medicina Tropical
2016-2025
Universidade do Estado do Amazonas
2016-2025
Escola Superior de Ciências da Saúde
2016-2025
Universidade Federal do Amazonas
2013-2025
Hospital Israelita Albert Einstein
2024
Universidade de São Paulo
2024
Centro Universitário Curitiba
2024
Universidade Federal do Acre
2020-2024
Amazon (Germany)
2021-2024
Universidade Federal de Santa Catarina
2022-2023
<h3>Importance</h3> There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the effect of chloroquine diphosphate (CQ) requires a high concentration drug. <h3>Objective</h3> To evaluate safety and efficacy 2 CQ dosages in patients with severe COVID-19. <h3>Design, Setting, Participants</h3> This parallel, double-masked, randomized, phase IIb clinical trial 81 adult who were hospitalized acute respiratory syndrome (SARS-CoV-2)...
Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating inflammatory response, mainly lungs, triggered by severe acute respiratory syndrome 2 (SARS-CoV-2). This study aimed to evaluate efficacy methylprednisolone (MP) among hospitalized patients with suspected COVID-19.A parallel, double-blind, placebo-controlled, randomized, Phase IIb clinical trial was performed aged ≥18 years clinical, epidemiological, and/or radiological COVID-19 at...
Treatment of Plasmodium vivax malaria requires the clearing asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from liver (a treatment termed "radical cure"). Tafenoquine is a single-dose 8-aminoquinoline that has recently been registered for radical cure P. vivax.
The outbreak of new coronavirus disease 2019 (COVID-19) reported for the first time in Wuhan, China late December have rapidly spread to other countries and it was declared on January 30, 2020 as a public health emergency international concern (PHEIC) by World Health Organization. Before COVID-19 cases were Brazil, several measures been implemented including adjustment legal framework carry out isolation quarantine. As increased significantly, measures, mainly reduce mortality severe cases,...
Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. parasitemia and hypnozoites, termed "radical cure."
Summary Background There is no specific antiviral therapy recommended for the disease caused by SARS-CoV-2 (COVID-19). Recent publications have drawn attention to possible benefit of chloroquine (CQ). Our study aimed comprehensively evaluate safety and efficacy two different CQ dosages in patients with established severe COVID-19. Methods We performed a parallel, double-blinded, randomized, phase IIb clinical trial, aiming assess as adjunctive hospitalized SARS Manaus, Brazilian Amazon....
The Amazon region reports the highest incidence of snakebite envenomings in Brazil. We aimed to describe epidemiology snakebites state Amazonas and investigate factors associated with disease severity lethality. used a nested case-control study, order identify mortality using official Brazilian reporting systems, from 2007 2012. Patients evolving or death were considered cases those non-severe bites included control group. During study period, 9,191 recorded, resulting an rate 52.8 per...
Envenomings by snakebites and scorpion stings impose a high burden worldwide result in considerable social economic impact [1]. It is estimated that snakebite rates are as over 1.8 million cases per year, with associated deaths reaching more than 90,000 annually [2]. However, neglected condition no WHO programmes for control prevention. The countries most affected located the intertropical zone areas of field use agriculture where main populations adult men working agricultural activities...
The new Coronavirus, called SARS-CoV-2, whose first cases emerged in Wuhan, China late December, 2019 and quickly spread to other countries, was declared on January 30, 2020 a public health emergency of international concern by the World Health Organization regional office for Europe. Even before COVID-19 were identified Brazil, country had articulated several measures ranging from creation ordinances laws, isolation quarantine. However, number has increased significantly, requiring...
COVID-19 is still placing a heavy health and financial burden worldwide. Impairment in patient screening risk management plays fundamental role on how governments authorities are directing resources, planning reopening, as well sanitary countermeasures, especially regions where poverty major component the equation. An efficient diagnostic method must be highly accurate, while having cost-effective profile. We combined machine learning-based algorithm with mass spectrometry to create an...
Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings adrenal glands 28 with confirmed SARS-CoV-2 infection. Microscopic lesions were identified 12/28 patients (46%). Seven cases showed necrosis, generally ischemic; four cortical lipid degeneration; two hemorrhage; and one unspecific focal adrenalitis. Vascular thrombosis patient inflammation association other three observed. No...
Population-based studies conducted in Latin America have shown a high proportion of asymptomatic and submicroscopic malarial infections. Considering efforts aiming at regional elimination, it is important to investigate the role this reservoir malaria transmission peri-urban areas. This study aimed estimate prevalence Plasmodium spp. gametocyte burden on symptomatic infections Brazilian Amazon. Two cross-sectional household surveys (CS) were including all inhabitants area Manaus, western...
Abstract Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) therefore major components of plasma holding insights into pathological processes. Here, we demonstrate plasma-derived EVs from patients ( Pv EVs) preferentially uptaken by spleen fibroblasts h SFs) as compared to uptake healthy individuals. Moreover, this...
Bothrops atrox snakes are mostly endemic of the Amazon rainforest and is certainly South American pit viper responsible for most snakebites in region. The composition B. venom significantly known has been used to trace relevance phenotype snake biology impacts clinics human patients involved accidents by atrox. However, spite wide distribution great medical snakes, taxonomy not fully resolved lack taxonomic resolution on studies focused or envenoming currently unknown. presents different...
Access to safe, effective, quality-assured antivenom products that are tailored endemic venomous snake species is a crucial component of recent coordinated efforts reduce the global burden snakebite envenoming. Multiple access barriers may affect journey antivenoms from manufacturers bedsides patients. Our review describes ecosystem at different levels and identifies solutions overcome these challenges. At level, there insufficient manufacturing output meet clinical needs, notably for...