A5021876583- Venomous Animal Envenomation and Studies
- Malaria Research and Control
- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- Rabies epidemiology and control
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Marine Invertebrate Physiology and Ecology
- Mycobacterium research and diagnosis
- Inflammasome and immune disorders
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Acute Lymphoblastic Leukemia research
- Hepatitis C virus research
- COVID-19 epidemiological studies
- Immune Response and Inflammation
- Insect and Pesticide Research
- Hematopoietic Stem Cell Transplantation
- Infectious Diseases and Tuberculosis
- Parasites and Host Interactions
- Hemoglobinopathies and Related Disorders
- Diagnosis and treatment of tuberculosis
- HIV Research and Treatment
Universidade Federal do Amazonas
2016-2025
Universidade do Estado do Amazonas
2016-2025
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas
2016-2025
Fundação de Medicina Tropical
2014-2024
Fundação Oswaldo Cruz
2022-2023
Universidade Federal do Espírito Santo
2023
Escola Superior de Ciências da Saúde
2017-2021
Hospital for Tropical Diseases
2021
Fundação Getulio Vargas
2020
University of Virginia
2020
Attack rate in Manaus Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) incidence peaked Manaus, Brazil, May 2020 with a devastating toll on the city's inhabitants, leaving its health services shattered and cemeteries overwhelmed. Buss et al. collected data from blood donors São Paulo, noted when transmission began to fall, estimated final attack rates October (see Perspective by Sridhar Gurdasani). Heterogeneities immune protection, population structure, poverty, modes of public...
Bothrops atrox snakes are mostly endemic of the Amazon rainforest and is certainly South American pit viper responsible for most snakebites in region. The composition B. venom significantly known has been used to trace relevance phenotype snake biology impacts clinics human patients involved accidents by atrox. However, spite wide distribution great medical snakes, taxonomy not fully resolved lack taxonomic resolution on studies focused or envenoming currently unknown. presents different...
Abstract Background The city of Manaus, north Brazil, was stricken by a second epidemic wave SARS-CoV-2 despite high seroprevalence estimates, coinciding with the emergence Gamma (P.1) variant. Reinfections were postulated as partial explanation for surge. However, accurate calculation reinfection rates is difficult when stringent criteria two time-separated RT-PCR tests and/or genome sequencing are required. To estimate proportion reinfections caused during in Manaus and protection...
Abstract The herd immunity threshold is the proportion of a population that must be immune to an infectious disease, either by natural infection or vaccination such that, in absence additional preventative measures, new cases decline and effective reproduction number falls below unity 1 . This fundamental epidemiological parameter still unknown for recently-emerged COVID-19, mathematical models have predicted very divergent results 2,3 Population studies using antibody testing infer total...
The high burden of drug-resistant tuberculosis (TB) is a problem to achieve the goals End TB Strategy by 2035. Whether isoniazid monoresistance (Hr) affects anti-TB treatment (ATT) outcomes remains unknown in high-burden countries.
Introduction Leukemia is the most common cancer in children and has highest rates of incidence industrialized countries, followed by developing countries. This epidemiologic profile can mainly be attributed to availability diagnostic resources. In Brazil, leukemia diagnosis a challenge due financial viability, lack hemovigilance services isolated regions vast size territory. Its state Amazonas been increasing since 2010. Therefore, this study aims describe epidemiological pattern spatial...
The presence of Plasmodium vivax malaria parasites in the human bone marrow (BM) is still controversial. However, recent data from a clinical case and experimental infections splenectomized nonhuman primates unequivocally demonstrated this tissue.In current study, we analyzed BM aspirates 7 patients during acute attack 42 days after drug treatment. RNA extracted CD71+ cell suspensions was used for sequencing transcriptomic analysis.We all infections. To provide further insights, purified...
Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity anemia in PWTB prior to anti-TB treatment (ATT) was risk factor for an unfavorable outcome.
Abstract Background The Xpert MTB/RIF rapid molecular test provides a quantitative measure of Mycobacterium tuberculosis (Mtb) DNA in the form cycle threshold (Ct) values. This information can be translated into mycobacterial load and used as potential risk bacterial spread for (TB) cases, which impact infection control. However, role Ct values assessing Mtb transmission to close contacts has not yet been demonstrated. Methods A prospective study was performed investigate association between...
Abstract There are insufficient predictors of progression to tuberculosis among contacts. A case-control study within RePORT-Brazil matched 20 QuantiFERON-positive progressors and 40 non-progressors by sex, age, exposure duration. Twenty-nine cytokines were measured Luminex in QuantiFERON-TB Gold Plus supernatants collected at baseline evaluated using machine learning for prediction. The same markers 8 QuantiFERON positive 12 from India. IL-8, IL-10, CCL3 levels predicted incident (AUC:...
Background Most longitudinal studies of COVID-19 incidence have used unlinked samples. The city Manaus, Brazil, has a blood donation program which allows sample linkage, and was struck by two large epidemic waves between mid-2020 early 2021. Methods We estimated the changing force infection, i.e. in susceptible individuals. Seroconversion inferred mixture model for serial values from Abbott Architect SARS-CoV-2 nucleocapsid (N) IgG assay. number suspected hospitalizations arising each...
Despite progress in healthcare for people living with HIV/AIDS (PLWHA), many still present advanced HIV, thus increasing their risk of death. Late initiation treatment and poor adherence to antiretroviral therapy (ART) are key contributing factors. This study aimed evaluate cytokines as mortality predictors among hospitalized PLWHA. It assessed the death between ART-naïve ART-non-adherent PLWHA HIV quantified immunological markers post-mortem samples determine influence irregular ART use. A...
In this study, we have evaluated the immunological status of hepatitis C virus (HCV)-infected patients aiming at identifying putative biomarkers associated with distinct degrees liver fibrosis. Peripheral blood and tissue T-cells as well cytokine levels were quantified by flow cytometry. Data analysis demonstrated higher frequency circulating CD8+ Tregs along a mixed proinflammatory/IL-10-modulated pattern in HCV patients. Patients severe fibrosis presented lower T-cells, proinflammatory...
Plasmodium vivax is the causative agent of human malaria large geographic distribution, with 35 million cases annually. In Brazil, it most prevalent species, being responsible by around 70 % cases. A cross-sectional study was performed in Manaus (Amazonas, Brazil), including 36 adult patients primary malaria, 19 recurrent and 20 endemic controls. The ex vivo phenotypic features circulating leukocyte subsets (CD4+ T-cells, CD8+ NK, NKT, B, B1 Treg cells) as well plasmatic cytokine profile...
Snakebites are a serious public health problem and, in the Amazon, Bothrops atrox snake is most frequent cause of envenomation. B. venom (BaV) causes pathophysiological changes with intense, local inflammatory processes, such as severe tissue complication (STC). However, mechanisms associated process humans still poorly understood. Thus, this study, we sought to describe profile and systemic immunological soluble molecules envenomation patients treated at specialist tertiary healthcare unit...
It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB).
Sickle Cell Anemia (SCA) is the most common genetic disorder around world. The mutation in β-globin gene responsible for a higher hemolysis rate, with further involvement of immunological molecules, especially cytokines, chemokines, growth factors, and anaphylatoxins. These molecules are inducing attracting immune cells into circulation, thus contributing to increases leukocytes other pro-inflammatory mediators, can culminate vaso-occlusive crisis (VOC). This study aimed characterize levels...
Background . Recent studies have shown that the inflammatory process, including biomarker production, and intense activation of innate immune responses are greater in malaria caused by Plasmodium vivax than other species. Here, we examined levels serum biomarkers their interaction during acute malaria. Material Methods Blood samples were collected from P. -infected patients at admission healthy donors. Levels measured Cytometric Bead Assay or ELISA. Results infection triggered production...
Tuberculosis (TB) still causes significant morbidity and mortality worldwide, especially in persons living with human immunodeficiency virus (HIV). This disease is hallmarked by persistent oxidative stress systemic inflammation. N-acetylcysteine (NAC), a glutathione (GSH) precursor, has been shown experimental models to limit Mycobacterium tuberculosis infection both suppression of the host response through direct antimicrobial activity. In recent phase II randomized clinical trial...
In the Brazilian Amazon, Bothrops atrox snakebites are frequent, and patients develop tissue damage with blisters sometimes observed in proximity of wound. Antivenoms do not seem to impact blister formation, raising questions regarding mechanisms underlying formation. Here, we launched a clinical laboratory-based study including five who followed were treated by standard protocols. Blister fluids collected for proteomic analyses molecular assessment presence venom antivenom. Although this...
The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines patients infected with different species Leishmania Amazonas State, Brazil. A comparative analysis was made serum concentrations these peripheral blood 33 cutaneous leishmaniasis. isolates were identified as guyanensis , L. naiffi amazonensis . Most (64%) male ranging age from 18 to 58 years. Protein expression profiles IL-2, IL-4, IL-6, IL-10, IFN- γ TNF-α, IL-17 shown vary significantly...
Abstract The COVID-19 pandemic threatens indigenous peoples living in suburban areas of large Brazilian cities and has thus far intensified their pre-existing socio-economic inequalities. We evaluated the epidemiological situation SARS-CoV-2 infection among residents biggest urban multiethnic community Amazonas state, Brazil. Blood samples 280 people surrounding area Manaus were tested for presence anti-SARS-CoV-2 IgA or IgG antibodies. risk factors sociodemographic information assessed...