A5073322625- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Systemic Lupus Erythematosus Research
- Sepsis Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Lymphocytic Leukemia Research
- Hemophilia Treatment and Research
- Blood groups and transfusion
- Blood properties and coagulation
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Complement system in diseases
- Blood disorders and treatments
- Neutropenia and Cancer Infections
- COVID-19 Clinical Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Mosquito-borne diseases and control
- Malaria Research and Control
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Angiogenesis and VEGF in Cancer
- Hematological disorders and diagnostics
Universidade Estadual de Campinas (UNICAMP)
2015-2024
Ministério da Saúde
2024
National Institute Of Blood Disease and Bone Marrow Transplantation
2023
Universidade do Estado do Amazonas
2019-2021
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas
2016-2021
Hospital de Clínicas da Unicamp
2020
Laboratório Nacional de Ciência e Tecnologia do Bioetanol
2016
HealthInsight
2015
Fundação Centro de Hematologia e Hemoterapia de Minas Gerais
2012
Children's Hospital of Philadelphia
2009
Abstract Housekeeping (HK) genes are constitutively expressed that required for the maintenance of basic cellular functions. Despite their importance in calibration gene expression, as well understanding many genomic and evolutionary features, important discrepancies have been observed studies previously identified these genes. Here, we present Reference Transcript Atlas (HRT v1.0, www.housekeeping.unicamp.br) a web-based database which addresses some limitations identification genes, offers...
In a phase I study, administration of an AAV2-FIX vector into the skeletal muscle eight hemophilia B subjects proved safe and achieved local gene transfer FIX expression for at least 10 months after injection, last time point assessed by biopsy. dogs we have demonstrated in both biopsies circulation >4 years following injection. Because circulating levels remained less than 1% normal human from duration AAV2-mediated transgene humans is unknown. We sought to determine if persisted locally...
Sickle cell disease (SCD) is an inherited hemoglobinopathy that caused by the presence of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations properties and shape, as result HbS dexoygenation subsequent polymerization. SCD pathophysiology characterized chronic inflammatory processes, triggered hemolytic vaso-occlusive events, which lead varied complications, organ damage elevated mortality seen individuals with disease. In association activation endothelium leukocytes,...
Pulmonary embolism (PE) has not been accounted for as a cause of death contributing to cause-specific mortality in global reports.We analyzed PE-related by focusing on the latest year available each member state World Health Organization (WHO) database, which provides age-sex-specific aggregated data transmitted national authorities underlying death. deaths were defined International Classification Diseases, Tenth Revision codes acute PE or nonfatal manifestations venous thromboembolism...
Abstract Management of Sepsis would greatly benefit from the incorporation simple and informative new biomarkers in clinical practice. Ideally, a sepsis biomarker should segregate infected non-infected patients, provide information about prognosis organ-specific damage be accessible to most healthcare services. The immature platelet fraction (IPF) reticulocyte (IRF) are analytical parameters complete blood count, that have been studied as several inflammatory conditions. Recently, study...
Folate and vitamin B12 are essential nutrients, whose deficiencies considerable public health problems worldwide, affecting all age groups. Low levels of these vitamins have been associated with high concentrations homocysteine (Hcy) can lead to complications. Several genetic polymorphisms affect the metabolism vitamins. The aims this study were assess folate, status in distinct Brazilian individuals after initiation folic acid fortification by authorities investigate effects RFC1 A80G,...
Coagulation activation is a prominent feature of severe acute respiratory syndrome coronavirus 2 (COVID-19) infection. Activation the contact system and intrinsic pathway has increasingly been implicated in prothrombotic state observed both sterile infectious inflammatory conditions. We therefore sought to assess individuals with COVID-19 Baseline plasma levels protease:serpin complexes indicative pathways were measured samples from inpatients healthy individuals. Cleaved kininogen,...
The differential diagnosis of immune (ITP) and hereditary macrothrombocytopenia (HM) is key to patient management. immature platelet fraction (IPF) represents the subset circulating platelets with higher RNA content, has been shown distinguish hypo- from hyperproliferative thrombocytopenias. Here we evaluated diagnostic accuracy IPF in between HM other thrombocytopenias a population patients post-chemotherapy thrombocytopenia (n = 56), bone marrow failure 22), ITP 105) 27). TPO levels were...
The presence of Plasmodium vivax malaria parasites in the human bone marrow (BM) is still controversial. However, recent data from a clinical case and experimental infections splenectomized nonhuman primates unequivocally demonstrated this tissue.In current study, we analyzed BM aspirates 7 patients during acute attack 42 days after drug treatment. RNA extracted CD71+ cell suspensions was used for sequencing transcriptomic analysis.We all infections. To provide further insights, purified...
In adults with immune thrombocytopenic purpura (ITP), steroids are usually proposed as first-line therapy, but long-term complete responses obtained in no more than 20% of patients. For the remaining patients, splenectomy is considered treatment choice, reported "cure" rates from 60–70%. However, inherent risks surgery and sepsis after without a guarantee success justify search for strategies aimed to avoid splenectomy. Here we retrospectively evaluated results dapsone ITP patients that...
Dengue cases have been classified according to disease severity into dengue fever (DF) and hemorrhagic (DHF). Although DF is considered a non-severe manifestation of dengue, it has recently demonstrated that represents heterogeneous group patients with varied clinical complications grades severity. Particularly, bleeding complications, commonly associated DHF, can be detected in half the DF. frequent complication, causes bleedings not fully addressed. Thus, aim this study was perform...
Hemoglobin SC disease is a very prevalent hemoglobinopathy; however, little known about this condition specifically. There appears to be an increased risk of thromboembolic events in hemoglobin disease, but studies evaluating the hemostatic alterations are lacking. We describe findings cross-sectional observational study coagulation activation markers adult patients with SC, comparing them those sickle cell anemia and healthy controls. A total 56 39 were included study, all steady state, 27...
A prolonged activated partial thromboplastin time (APTT) of unknown cause is one the most frequent reasons why outpatients are referred for hemostasis consultation. Nevertheless, very few data available on relative contribution individual causes this common clinical scenario. Here, we present a systematic evaluation all APTT prolongation in consecutive population specialized consultation during 14-year period.All cases to an academic outpatient unit due etiology whose was confirmed first...
Sickle Cell Anemia (SCA) is the most common genetic disorder around world. The mutation in β-globin gene responsible for a higher hemolysis rate, with further involvement of immunological molecules, especially cytokines, chemokines, growth factors, and anaphylatoxins. These molecules are inducing attracting immune cells into circulation, thus contributing to increases leukocytes other pro-inflammatory mediators, can culminate vaso-occlusive crisis (VOC). This study aimed characterize levels...