A5037881186- COVID-19 Clinical Research Studies
- Lymphatic System and Diseases
- Lipid metabolism and disorders
- Hemoglobinopathies and Related Disorders
- Blood properties and coagulation
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Dermatological and COVID-19 studies
- Biomarkers in Disease Mechanisms
- Iron Metabolism and Disorders
- Retinoids in leukemia and cellular processes
- Phagocytosis and Immune Regulation
- Musculoskeletal Disorders and Rehabilitation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cutaneous lymphoproliferative disorders research
- Traumatic Brain Injury and Neurovascular Disturbances
- Innovations in Medical Education
- Viral gastroenteritis research and epidemiology
- Apelin-related biomedical research
- Vector-Borne Animal Diseases
- Sepsis Diagnosis and Treatment
- Extracellular vesicles in disease
- Health and Medical Research Impacts
- Heme Oxygenase-1 and Carbon Monoxide
Universidade Estadual de Campinas (UNICAMP)
2020-2024
Coagulation activation is a prominent feature of severe acute respiratory syndrome coronavirus 2 (COVID-19) infection. Activation the contact system and intrinsic pathway has increasingly been implicated in prothrombotic state observed both sterile infectious inflammatory conditions. We therefore sought to assess individuals with COVID-19 Baseline plasma levels protease:serpin complexes indicative pathways were measured samples from inpatients healthy individuals. Cleaved kininogen,...
Endothelial barrier (EB) disruption contributes to acute lung injury in COVID-19, and levels of both VEGF-A Ang-2, which are mediators EB integrity, have been associated with COVID-19 severity. Here we explored the participation additional integrity this process, as well potential serum from patients induce cell monolayers. In a cohort clinical trial consisting thirty that required hospital admission due hypoxia demonstrate i) soluble Tie2 were increase, VE-cadherin decreased when compared...
Coagulation activation in immunothrombosis involves various pathways distinct from classical hemostasis, offering potential therapeutic targets to control inflammation-induced hypercoagulability while potentially sparing hemostasis. The Angiopoietin/Tie2 pathway, previously linked embryonic angiogenesis and sepsis-related endothelial barrier regulation, was recently associated with coagulation sepsis COVID-19. This study explores the connection between key mediators of pathway activation....
Heme-oxygenase 1 (HO-1) is an enzyme with well-known anti-inflammatory and antioxidant properties, whose levels have been previously associated disease severity in the context of sterile infectious diseases. Moreover, heme/HO-1 pathway has prothrombotic changes other Accordingly, potential modulating HO-1 for treatment COVID-19 was extensively speculated during pandemic, but very few actual data were generated. The aim our study to explore association HO-1, heme, hemopexin (HPX) markers...
Heme is a fundamental molecule for several biological processes, but when released in the extracellular space such as hemolytic diseases, it can be toxic to cells and tissues. Hemopexin (HPX) circulating protein responsible removing free heme from circulation, whose levels severely depleted conditions sickle cell diseases. Accordingly, increasing HPX represents an attractive strategy mitigate deleterious effects of these conditions. Gene transfer liver-produced proteins with adeno-associated...
Podoplanin (PDPN gene) and CLEC-2 are involved in inflammatory hemostasis have also been related with the pathogenesis of thrombosis. Emerging evidence suggest that podoplanin can exert protective effects sepsis acute lung injury. In lungs, is co-expressed ACE2, which main entry receptor for SARS-CoV-2.To explore role COVID-19.Circulating levels were measured 30 consecutive COVID-19 patients admitted due to hypoxia, age- sex-matched healthy individuals. expression lungs from who died was...
Hemolytic diseases such as Sickle Cell Disease (SCD) are characterized by a natural propensity for both arterial and venous thrombosis. The ability of heme to induce tissue factor (TF) activation has been shown in animal models SCD, human endothelial cells monocytes. Moreover, it was recently demonstrated that can coagulation the whole blood healthy volunteers TF-dependent fashion. Herein, we aim further explore cellular mechanisms which induces TF-coagulation activation, using mononuclear...
Abstract Introduction Hemolytic diseases such as Sickle Cell Disease (SCD) are characterized by a natural propensity for both arterial and venous thrombosis. Evidence showing that heme can induce tissue factor (TF) expression in endothelial cells TF-dependent coagulation activation animal models of SCD suggest contribute to hypercoagulability this condition. We recently demonstrated whole blood healthy volunteers fashion. Methods Herein, we aimed evaluate whether heme-induced activity was...
Background: Platelets are involved in hemostasis and innate immune processes.Dengue (DENV) Zika (ZIKV) viruses' encodes 3 structural 7 nonstructural proteins.Nonstructural protein 1 (NS1) is mainly the replication of viral genetic material.NS1 can be secreted into extracellular microenvironment has been associated with response evasion.Aims: The aim this work was to evaluate platelet NS1 dengue viruses.Methods: Blood samples were obtained from healthy volunteers by venipuncture after signing...
Conclusion(s): This data indicates platelets undergo changes after the first dose of chemotherapy.In order to observe impact in each cancer type and progression, long term follow up are required.These studies can help understand how be targeted improve outcomes therapies those patients.