A5011716073- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Tuberculosis Research and Epidemiology
- Parasites and Host Interactions
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- COVID-19 Impact on Reproduction
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Toxin Mechanisms and Immunotoxins
- Urticaria and Related Conditions
- Eosinophilic Disorders and Syndromes
- T-cell and Retrovirus Studies
- Immune responses and vaccinations
- Vaccine Coverage and Hesitancy
- Infectious Diseases and Tuberculosis
- Machine Learning in Healthcare
- Long-Term Effects of COVID-19
- Paraoxonase enzyme and polymorphisms
- Clostridium difficile and Clostridium perfringens research
- Galectins and Cancer Biology
- Fungal and yeast genetics research
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
Instituto Evandro Chagas
2015-2025
Fundação Oswaldo Cruz
2013-2025
The University of Melbourne
2023
Murdoch Children's Research Institute
2023
Universidade de Ribeirão Preto
2018
Universidade de São Paulo
2018
Universidade Federal de Uberlândia
2008
The bacille Calmette-Guérin (BCG) vaccine has immunomodulatory "off-target" effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19).
Summary Suitable levels of interferon (IFN)-γ and interleukin (IL)-10 seem to favour the outcome cutaneous leishmaniasis (CL), while high IFN-γ low IL-10 production are associated with severity mucosal (ML). Considering that cytokine balance is important for maintenance protective responses in leishmaniasis, our aim was investigate leishmanial antigens-induced maintained healed individuals who had different clinical outcomes Leishmania infection. Thirty-three recovered from L. braziliensis...
Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity anemia in PWTB prior to anti-TB treatment (ATT) was risk factor for an unfavorable outcome.
The high burden of drug-resistant tuberculosis (TB) is a problem to achieve the goals End TB Strategy by 2035. Whether isoniazid monoresistance (Hr) affects anti-TB treatment (ATT) outcomes remains unknown in high-burden countries.
SUMMARY The lack of an adequate model for Leishmania ( Viannia ) braziliensis infection is a limiting factor studying American tegumentary leishmaniasis (ATL). golden hamster Mesocricetus auratus promising because besides being highly susceptible to dermotropic infection, the lesions are very similar cutaneous (CL) in humans. However, different isolates or species and/or protocols have resulted outcomes, whereas no study has evaluated reproducibility L. this model. natural history 34...
In the Brazilian Amazon, American tegumentary leishmaniasis (ATL) is endemic and presents a wide spectrum of clinical manifestations due, in part, to circulation at least seven Leishmania species. Few reports (Viannia) naiffi infection suggest that its occurrence uncommon reported cases present benign course good response treatment. This study aimed strengthen epidemiological importance L. (V.) Amazon Region (Manaus, state Amazonas) report therapeutic failure patients infected with this...
Abstract Background The Xpert MTB/RIF rapid molecular test provides a quantitative measure of Mycobacterium tuberculosis (Mtb) DNA in the form cycle threshold (Ct) values. This information can be translated into mycobacterial load and used as potential risk bacterial spread for (TB) cases, which impact infection control. However, role Ct values assessing Mtb transmission to close contacts has not yet been demonstrated. Methods A prospective study was performed investigate association between...
Abstract Background Interferon-gamma is a key cytokine in the protective responses against intracellular pathogens. A single nucleotide polymorphism (SNP) located first intron of human IFN-γ gene can putatively influence secretion with an impact on infection outcome as demonstrated for tuberculosis and other complex diseases. Our aim was to investigate putative association IFNG+874T/A SNP American tegumentary leishmaniasis (ATL) also this vitro . Methods Brazilian ATL patients (78 cutaneous,...
It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB).
The prevalence and characteristics of chronic Chagas disease (CCD) in the Amazon Region remain underexplored. This study aimed to describe challenges encountered during a serological survey follow-up CCD, while also highlighting potential risk factors Region. involved residents periurban rural areas Manaus Brazilian Amazon. All participants were invited complete clinical, epidemiological, demographic questionnaire provide blood sample for anti- Trypanosoma cruzi ( T. ) IgG tests. A total...
ABSTRACT The golden hamster ( Mesocricetus auratus ) is a susceptible model to Leishmania Viannia spp.; however, available studies employ different infection protocols, which account for clinical and pathological presentation differences. Herein, L . V .) braziliensis preparations were standardized contain 10 4 , 5 or 6 parasites determine an optimal inoculum that ensured cutaneous lesions without causing disseminated in hamsters. Lesion development was followed 105 days by size...
Abstract Background Despite widespread availability of curative therapy, tuberculosis (TB) treatment outcomes remain suboptimal. Clinical prediction models can inform strategies to improve outcomes. Using baseline clinical data, we developed a model for unsuccessful TB outcome and evaluated the incremental value human immunodeficiency virus (HIV)–related severity isoniazid acetylator status. Methods Data originated from Regional Prospective Observational Research Tuberculosis Brazil cohort,...
This survey aims to estimate the prevalence of intestinal parasitic infections in Santa Isabel do Rio Negro, Amazonian Brazil, through three distinct techniques, correlating rates with family income and age groups as well assessing household clustering infections. Prevalence were assessed Graham (n = 113), Baermann-Moraes 232) Ritchie 463) methods. The method was adopted only for children under 5 years old, 15% whom positive Enterobius vermicularis. By technique, 5·6% samples Strongyloides...
American tegumentary leishmaniasis (ATL) is an infectious disease caused mostly by Leishmania(Viannia)braziliensis in Southeast Brazil. The clinical manifestations are vast, ranging from asymptomatic to severe mucosal (ML). It has been suggested that variation of the pathogen does not fully explain response spectrum and variability manifestations. Previous data have shown host genetics also play a role outcome. Herein, we tested association TNF, IL10, IL12 MIF single nucleotide polymorphisms...
Previous results have shown that oral and intranasal administration of particulate Leishmania (Leishmania) amazonensis antigens (LaAg) partially protects mice against L. infection. However, vaccination studies on species the subgenus Viannia, main causative agent cutaneous mucosal leishmaniasis in Americas, been hampered by lack easy-to-handle bio-models accurately mimic human disease. Recently, we demonstrated golden hamster is an appropriate model for studying immunopathogenesis caused...
It is unknown whether dysglycemia associated with Mycobacterium tuberculosis transmission.We assessed epidemiological and clinical characteristics of patients culture-confirmed pulmonary their close contacts, enrolled in a multicenter prospective cohort Brazil. Contacts were investigated at baseline 6 months after enrollment. QuantiFERON positivity conversion (from negative to positive month 6) compared between subgroups contacts according glycemic status persons (PWTB) as diabetes mellitus...
Total antigen from Leishmania (Leishmania) amazonensis and isolates the braziliensis complex, along with their respective antigenic fractions obtained by affinity chromatography on concanavalin-A-Sepharose jacalin-agarose columns evaluated using immunoenzymatic ELISA assay. For this, serum samples 229 patients were used, grouped as American tegmental leishmaniasis (nº=58), visceral (nº=28), Chagas disease (nº=49), malaria (nº=32), tuberculosis (nº=13) healthy volunteers (nº=49). Samples...
Summary For better efficiency in the establishment of American tegumentary leishmaniasis clinical cure, World Health Organization suggests that criteria are supported by serologic data. The present study aims to investigate dynamics IgG subclass production evolution post‐treatment cutaneous (CL). Paired sera from 23 subjects with CL resulting Leishmania braziliensis infection were studied during active lesion phase (aCL) and after cure post‐therapy (hCL), which included an alternative...
Abstract Diabetes mellitus (DM) increases tuberculosis (TB) severity. We compared blood gene expression in adults with pulmonary TB, or without diabetes from sites Brazil and India. RNA sequencing (RNAseq) performed at baseline during TB treatment. Publicly available RNAseq data South Africa Romania reported by the TANDEM Consortium were also analyzed. Across sites, differentially expressed genes varied for each condition (DM, TBDM) no pattern classified any one group across all sites. A...
Gold miners working illegally in mines live poor health conditions related to their strenuous work and precarious housing. Therefore, they are at higher risk for infectious diseases. American tegumentary leishmaniasis (ATL) appears be of great concern the population living Guiana Shield region. Our aim was describe demographic characteristics, clinical features cutaneous (CL), frequency Leishmania infection people illegal gold French Guiana. A cross-sectional study carried out from October...
Leishmania (Viannia) braziliensis control and tissue damage relate to the effector immune response, which in turn affects clinical outcome. reactive CD4+ CD8+ T cells are expanded long-term healed cutaneous leishmaniasis (hCL) patients but their functional characteristics remain be determined. This study investigates antigen-specific recall CL caused by L. infection. Healed subjects were grouped according time elapsed since end of therapy: less than two years five years. Activation phenotype...
We report the case of a 32-year-old man from Rio de Janeiro, who was infected in Amazon region Brazil by Leishmania (Viannia) naiffi. Generally, patients with L. naiffi cutaneous leishmaniasis exhibit good therapeutic response to either pentavalent antimonials or pentamidine. However, after pentamidine treatment, this patient's infection evolved failure. To understand clinical outcome, we investigated presence RNA virus (LRV) parasites isolated lesion; herein, discuss possible association...
Leishmaniasis is an important parasitic disease affecting millions worldwide. Human cutaneous leishmaniasis (CL) endemic in Rio de Janeiro, Brazil, where caused by Leishmania braziliensis. The adaptive immune response accountable for the healing of CL and despite key role CD8+ T cells this little known about lymphocytes frequencies, apoptosis antigen-responsive patients during antimonial therapy.Using flow cytometry, we examined total effector from before (PBT), (PDT) after (PAT) treatment...
Immunological control of Mycobacterium tuberculosis infection is dependent on the cellular immune response, mediated predominantly by Th1 type CD4+ T cells. Polarization response to Th2 can inhibit host protection against pathogens. Patients with coinfected helminths demonstrate more severe pulmonary symptoms, a deficiency in tuberculosis, and an impaired anti-tuberculosis therapy.We evaluated impact presence Ascaris lumbricoides clinical patients. Ninety-one individuals were included study:...