A5044797842- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Zoonotic diseases and public health
- HIV/AIDS oral health manifestations
- Vibrio bacteria research studies
- Fungal Infections and Studies
- HIV/AIDS drug development and treatment
- Malaria Research and Control
- Autoimmune and Inflammatory Disorders Research
- Infectious Diseases and Mycology
- Machine Learning in Healthcare
- Blood groups and transfusion
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cytomegalovirus and herpesvirus research
- Clostridium difficile and Clostridium perfringens research
- Eosinophilic Disorders and Syndromes
- Vitamin D Research Studies
- Mosquito-borne diseases and control
- Actinomycetales infections and treatment
- Pharmacovigilance and Adverse Drug Reactions
Fundação de Medicina Tropical
2019-2024
Universidade Federal do Amazonas
2021-2024
Universidade do Estado do Amazonas
2019-2024
Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity anemia in PWTB prior to anti-TB treatment (ATT) was risk factor for an unfavorable outcome.
The high burden of drug-resistant tuberculosis (TB) is a problem to achieve the goals End TB Strategy by 2035. Whether isoniazid monoresistance (Hr) affects anti-TB treatment (ATT) outcomes remains unknown in high-burden countries.
Abstract Background The Xpert MTB/RIF rapid molecular test provides a quantitative measure of Mycobacterium tuberculosis (Mtb) DNA in the form cycle threshold (Ct) values. This information can be translated into mycobacterial load and used as potential risk bacterial spread for (TB) cases, which impact infection control. However, role Ct values assessing Mtb transmission to close contacts has not yet been demonstrated. Methods A prospective study was performed investigate association between...
It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB).
Tuberculosis (TB) still causes significant morbidity and mortality worldwide, especially in persons living with human immunodeficiency virus (HIV). This disease is hallmarked by persistent oxidative stress systemic inflammation. N-acetylcysteine (NAC), a glutathione (GSH) precursor, has been shown experimental models to limit Mycobacterium tuberculosis infection both suppression of the host response through direct antimicrobial activity. In recent phase II randomized clinical trial...
Abstract Background Despite widespread availability of curative therapy, tuberculosis (TB) treatment outcomes remain suboptimal. Clinical prediction models can inform strategies to improve outcomes. Using baseline clinical data, we developed a model for unsuccessful TB outcome and evaluated the incremental value human immunodeficiency virus (HIV)–related severity isoniazid acetylator status. Methods Data originated from Regional Prospective Observational Research Tuberculosis Brazil cohort,...
Abstract Background Tuberculosis (TB) treatment–related adverse drug reactions (TB-ADRs) can negatively affect adherence and treatment success rates. Methods We developed prediction models for TB-ADRs, considering participants with drug-susceptible pulmonary TB who initiated standard therapy. TB-ADRs were determined by the physician attending participant, assessing causality to drugs, affected organ system, grade. Potential baseline predictors of TB-ADR included concomitant medication (CM)...
To assess the spatial distribution of TB and malaria incidence, as well their association with each other, regardless environmental socio-economic factors commonly reported determinants both disease rates among municipalities Amazonas State, Brazil between 2012 2015.Through an ecological approach considering Amazonas, Brazil, unit analysis, a negative binomial regression model was used to rates, in which dependent variable average municipal tuberculosis incidence rate.Positive associations...
Approximately 10% of the global tuberculosis (TB) burden is in children. Identification, diagnosis, and early treatment Mycobacterium infection (TBI) critical to prevent progression TB The risk TB, including severe disease, highest children <5 years old. We evaluated cascade TBI care among child adolescent contacts identify factors associated with losses cascade.Close ≤ 18 old pulmonary patients enrolled between 2015 2019 a multi-centre Brazilian cohort were followed for up 24 months...
GeneXpert® Edge (GX-Edge) is a new point-of-care platform not yet tested in the field. In this proof-of-concept study conducted for diagnosis of tuberculosis communities living alongside two large rivers Brazilian Amazon, we demonstrate that GX-Edge implemented boats to offer onsite testing feasible strategy investigate potentially devastating diseases such as difficult-to-reach populations, riverside communities.
The interferon gamma release assay (IGRA) has emerged as a useful tool for identifying latent tuberculosis infection (LTBI). This can be performed through testing platforms such the QuantiFERON-TB Gold Plus (QFT-Plus) assay. in vitro test been incorporated into several guidelines worldwide and recently considered by World Health Organization (WHO) diagnosis of LTBI. possibility systematically implementing IGRAs QFT-Plus centers that perform LTBI screening accelerated decreased availability...
There are scarce data on the prevalence and disease presentation of HIV in patients with tuberculosis (TB) dysglycemia (diabetes [DM] prediabetes [PDM]), especially TB-endemic countries.We assessed baseline epidemiological clinical characteristics culture-confirmed pulmonary TB, enrolled a multicenter prospective cohort Brazil (RePORT-Brazil) during 2015-2019. Dysglycemia was defined by elevated glycated hemoglobin stratified as PDM or DM. Additionally, we used from TB cases obtained through...
Introduction Tuberculosis (TB) is a common opportunistic infection among people living with HIV. Diagnostic tests such as culture, Xpert-MTB-RIF, and ULTRA have low sensitivity in paucibacillary TB disease; blood biomarker could improve diagnostic capabilities. We assessed soluble factors to identify biomarkers associated persons advanced Methods A case-control (1:1) study was conducted, participants from Rio de Janeiro Manaus, Brazil. People HIV presenting CD4 count ≤100 cells/mm3 were...
Hemophagocytic lymphohistiocytosis (HLH) is a disorder that occurs due to unsuitable monocyte activation in variety of infections. In human immunodeficiency virus (HIV) infections, patients with advanced immunossupression associated opportunistic infections are at increased risk developing HLH. We describe clinical case 33-year-old male student diagnosed HIV who was hospitalized for investigation asthenia and dyspnea, accompanied by adynamia, decreased motor force the left leg, dysphagia,...
Tuberculosis (TB) causes 1 in 3 deaths among people living with HIV (PLHIV). Diagnosing and treating latent tuberculosis infection (LTBI) is critical to reducing TB incidence mortality. Blood-based screening tests (e.g., QuantiFERON-TB Gold Plus (QFT+)) shorter-course preventive therapy (TPT) regimens such as 3HP (3 months weekly isoniazid-rifapentine) hold significant promise improve outcomes. We qualitatively explored barriers solutions optimizing QFT+ PLHIV three cities Brazil. conducted...
Bacteriological confirmation of extrapulmonary tuberculosis (EPTB) is challenging for several reasons: the paucibacillary nature sample; scarce resources, mainly in middle and low-income countries; need hospitalization; unfavorable outcomes. We evaluated diagnostic role respiratory specimen examination prospectively a cohort patients with presumptive EPTB.
Abstract Background There are scarce data on the prevalence and disease presentation of HIV in patients with tuberculosis (TB) dysglycemia (diabetes [DM] prediabetes [PDM]), especially TB-endemic countries. Methods We assessed baseline epidemiological clinical characteristics culture-confirmed pulmonary TB, enrolled a multicenter prospective cohort Brazil (RePORT-Brazil) during 2015-2019. Dysglycemia was defined by elevated glycated hemoglobin stratified as PDM or DM. Additionally, we used...
ABSTRACT Background It is unclear whether diabetes or prediabetes drives adverse treatment outcomes and death in people with tuberculosis (PWTB). Methods Culture-confirmed PWTB, enrolled the Regional Prospective Observational Research Tuberculosis (RePORT)-Brazil cohort between 2015 2019 (n=756) were stratified based on glycemic status by baseline glycated hemoglobin levels. Unfavorable TB outcome was defined as failure modification, recurrence death, whereas favorable cure completion. We...
Background: Approximately 10% of the global tuberculosis (TB) burden is in children. Identification, diagnosis, and early treatment Mycobacterium infection (TBI) critical to prevent progression TB The risk TB, including severe disease, highest children < 5 years old. We evaluated cascade TBI care among child adolescent contacts identify factors associated with losses cascade. Methods: Close ≤ 18 old pulmonary patients enrolled between 2015 2019 a multi-center Brazilian cohort were followed...
Background: Identification of Mycobacterium tuberculosis infection (TBI) is essential to prevent progression (TB) in children and adolescents.Methods: Close contacts pulmonary TB patients enrolled between 2015 2019 a multi-center Brazilian cohort study were followed for up 24 months classified according age group: <5 years, 5-9 10-14 years 15-18 >18 old (the reference group). Clinical evaluation, radiographic examination, interferon gamma release assay (IGRA) testing at baseline month 6,...
Abstract Background Interferon-gamma release assay (IGRA) has emerged as a useful tool in identifying latent tuberculosis infection (LTBI). This can be performed through testing platforms, such QuantiFERON-TB Gold Plus (QFT ® -Plus). vitro test been incorporated by several guidelines worldwide and recently considered for the diagnosis of LTBI World Health Organization (WHO). The possibility systematically implementing IGRAs QFT -Plus centers that perform screening accelerated decreased...