A5056978892- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Eosinophilic Disorders and Syndromes
- Nutrition and Health in Aging
- Toxin Mechanisms and Immunotoxins
- Toxoplasma gondii Research Studies
- Parasite Biology and Host Interactions
- Science and Education Research
- Parasitic Infections and Diagnostics
- Clinical Nutrition and Gastroenterology
- Hepatitis Viruses Studies and Epidemiology
- Leptospirosis research and findings
- T-cell and Retrovirus Studies
- Insect and Pesticide Research
- HIV/AIDS Research and Interventions
- Parasitic Diseases Research and Treatment
- Parvovirus B19 Infection Studies
- Hydrogels: synthesis, properties, applications
- Urticaria and Related Conditions
- Mast cells and histamine
- Viral Infections and Vectors
- Autoimmune and Inflammatory Disorders Research
- Syphilis Diagnosis and Treatment
- Healthcare Regulation
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2009-2025
Universidade de São Paulo
2016-2025
Universidade Brasil
1996-2021
Universidade Federal do Paraná
2014
University of Naples Federico II
2013
Hospital Santa Paula
2000
Universidade Federal de Goiás
1999
Instituto do Coração
1995
Mucosal leishmaniasis (ML) is an important endemic disease and public-health problem in underdeveloped countries because of its significant morbidity mortality. Increases ecological tourism have extended this to developed countries. This form leishmaniasis, caused by reactivation after primary cutaneous lesion, has a natural history progressive destruction the nasal septa soft hard palates, causing facial disfiguration leading respiratory disturbances. Treatment ML, based on several...
Background Leishmania (Viannia) braziliensis is a parasite recognized as the most important etiologic agent of mucosal leishmaniasis (ML) in New World. In Amazonia, seven different species Leishmania, agents human Cutaneous Leishmaniasis, have been described. Isolated cases ML described for several Leishmania: L. (V.) panamensis, guyanensis and (L.) amazonensis. Methodology were characterized by polymerase chain reaction (PCR) tissues taken from biopsies Amazonian patients who diagnosed with...
Summary Suitable levels of interferon (IFN)-γ and interleukin (IL)-10 seem to favour the outcome cutaneous leishmaniasis (CL), while high IFN-γ low IL-10 production are associated with severity mucosal (ML). Considering that cytokine balance is important for maintenance protective responses in leishmaniasis, our aim was investigate leishmanial antigens-induced maintained healed individuals who had different clinical outcomes Leishmania infection. Thirty-three recovered from L. braziliensis...
Comorbidity from tegumentary leishmaniasis and AIDS is poorly characterized.To describe a series of patients coinfected with Leishmania human immunodeficiency virus (HIV).Clinical records were analysed by demographic data, clinical manifestations, diagnoses, treatments outcomes.Fifteen cases AIDS/tegumentary found. The diagnosis was confirmed the detection amastigotes or antigens cutaneous mucosal lesions. mean CD4+ T-cell count 84 cells mm(-3) (range 8-258) all classified as having...
The aim of this study was to compare resting energy expenditure (REE) measured (MREE) by indirect calorimetry (IC) and REE predicted (PREE) from established predictive equations in a large sample obese Caucasian adults.We evaluated 1851 patients (body mass index (BMI)>30 kg m-2) aged between 18a 65 years. Data were obtained comparing MREE with PREE, derived different equations, within normal weight groups. mean differences PREE as well the accuracy prediction ±10% level investigated whole...
American tegumentary leishmaniasis (ATL), an endemic anthropozoonosis in various countries the world, is caused by parasites of genus Leishmania. Despite reports on ATL reactivation as a result immunosuppression, to best our knowledge, this paper describes first case its localized form (cutaneous leishmaniasis) associated with administration systemic corticosteroids. The possible action corticosteroids host immune response parasite patients cutaneous discussed. This report demonstrates...
Abstract Background Interferon-gamma is a key cytokine in the protective responses against intracellular pathogens. A single nucleotide polymorphism (SNP) located first intron of human IFN-γ gene can putatively influence secretion with an impact on infection outcome as demonstrated for tuberculosis and other complex diseases. Our aim was to investigate putative association IFNG+874T/A SNP American tegumentary leishmaniasis (ATL) also this vitro . Methods Brazilian ATL patients (78 cutaneous,...
Abstract Background Concomitant infections may influence HIV progression by causing chronic activation leading to decline in T-cell function. In the Americas, visceral (AVL) and tegumentary leishmaniasis (ATL) have emerged as important opportunistic HIV-AIDS patients both of those diseases been implicated potentially co-factors disease progression. We investigated whether increases lymphocyte HIV-1 co-infected patients. This might contribute impaired cellular immune Methods To address this...
Studies assessing the efficacy of liposomal amphotericin B (LAB) in treatment patients with mucosal leishmaniasis (ML) are very scarce literature and an optimal dose regimen has not yet been defined.We performed a retrospective descriptive analysis from records 16 ML treated LAB. The mean daily LAB was 2.5 mg/kg/day.Healing lesion observed 14 (88%) patients. cumulative doses, excluding two failures, were 2265 mg 33 mg/kg.Liposomal 30 to 35 mg/kg able achieve 100% effectiveness.
In view of the action newer macrolide antibiotics on intracellular protozoa, we have investigated efficacy roxithromycin in treatment cryptosporidiosis 26 patients with AIDS. Cryptosporidiosis was confirmed either by faecal examination for parasites (modified Kinyoun method) or detection parasite biopsy material obtained colonoscopy. Patients received oral (300 mg bd) 4 weeks. Twenty-two completed study. At end study, 15 (68%) were considered to be cured and six (27%) improved, failed one...
Abstract Background Immunosuppression increases the risk of primary cutaneous leishmaniasis (CL) infection and its reactivation. This systematic review examined CL reactivation in immunosuppressed patients, including those with autoimmune diseases solid organ transplant recipients. Methods A comprehensive literature search was conducted across multiple databases for studies published between May 1990 2024. Results Nine cases were selected, involving associated immunosuppressive therapy...
Summary The Toll‐like receptor (TLR) signalling pathway is the first system that defends against Leishmania. After recognising Leishmania as nonself, TLRs trigger NF‐κB expression. proceeds to nucleus and promotes transcription of pro‐inflammatory cytokines. TLR9 thus an important factor in induction effective immune response We examined pattern expression 12 patients with cutaneous leishmaniasis caused by braziliensis detected polymerase chain reaction. Normal skin was analysed a negative...
Abstract Background Recently, there has been an increase in the incidence of cutaneous leishmaniasis (CL), which represents important health problem. This may be related to epidemiologic expansion infective agent and tourism tropical areas. The difficulty clinical diagnosis, mainly areas CL is not first consideration local physicians, intensified efforts describe diagnostic tests, should specific, sensitive, practical. Amongst new tests described are those including nucleic acid...
Liposomal amphotericin B has been used as an alternative treatment of mucosal leishmaniasis, but the optimal dose is not established. We retrospectively reviewed clinical outcome eight patients with leishmaniasis treated liposomal B. The mean total was 35 mg/kg (range 24-50 mg/kg), which resulted in healing all lesions and no recurrences were observed during follow-up period (mean 25 months; range 7-40 months).