A5041095272- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- SARS-CoV-2 and COVID-19 Research
- T-cell and Retrovirus Studies
- Toxin Mechanisms and Immunotoxins
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Urticaria and Related Conditions
- Eosinophilic Disorders and Syndromes
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Advanced Drug Delivery Systems
- Parasitic Infections and Diagnostics
- Hydrogels: synthesis, properties, applications
- Pesticide Residue Analysis and Safety
- Synthesis and Characterization of Heterocyclic Compounds
- Cytomegalovirus and herpesvirus research
- Autoimmune and Inflammatory Disorders Research
- Parasitic infections in humans and animals
- Polymer Surface Interaction Studies
- Parasitic Diseases Research and Treatment
- Fungal Infections and Studies
- Synthesis and biological activity
Universidade de São Paulo
2006-2025
Instituto de Medicina Tropical
2019-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2008-2020
Instituto de Medicina Avançada
2020
Abstract Background Immunosuppression increases the risk of primary cutaneous leishmaniasis (CL) infection and its reactivation. This systematic review examined CL reactivation in immunosuppressed patients, including those with autoimmune diseases solid organ transplant recipients. Methods A comprehensive literature search was conducted across multiple databases for studies published between May 1990 2024. Results Nine cases were selected, involving associated immunosuppressive therapy...
Liposomal amphotericin B has been used as an alternative treatment of mucosal leishmaniasis, but the optimal dose is not established. We retrospectively reviewed clinical outcome eight patients with leishmaniasis treated liposomal B. The mean total was 35 mg/kg (range 24-50 mg/kg), which resulted in healing all lesions and no recurrences were observed during follow-up period (mean 25 months; range 7-40 months).
Rheumatoid arthritis (RA) is a chronic condition that frequent in patients living tropical areas exposed to leishmaniasis. RA therapy involves immunosuppressant drugs such as methotrexate (MTX), monoclonal antibodies (mAbs) and prednisone. We report an unusual presentation of cutaneous (CL) or mucocutaneous leishmaniasis (ML) from endemic area A 51-year-old woman noted ulcer on her left ankle during MTX prednisone therapy. Initially diagnosed venous stasis ulcer, the aspirate injury revealed...
Liposomal amphotericin B (L-AMB) has been used for mucosal leishmaniasis (ML), but comparative studies on L-AMB and other drugs the treatment of ML have not conducted. The present study aimed to evaluate outcome patients with who were treated L-AMB.This is a 15-year retrospective Brazilian confirmed diagnosis ML. therapeutic options consisted L-AMB, lipid complex (ABLC), deoxycholate (d-AMB), itraconazole, antimonial pentavalent, or pentamidine. Healing, cure rate adverse effects (AEs)...
Meglumine antimoniate (MA) remains the main treatment for cutaneous leishmaniasis (CL). Uncontrolled studies suggest that intralesional MA (IL-MA) may be noninferior and safer than systemic (S-MA).Multicenter, randomized, controlled, open-label, phase 3 clinical trial to evaluate efficacy toxicity of IL-MA in infiltrations at 14-day intervals compared with S-MA (10-20 mg Sb5+/kg/day, 20 days) CL, noninferiority margin 20%. Primary secondary outcomes were definitive cure day 180...
SUMMARY It is important to develop new methods for diagnosing relapses in the co-infection of visceral leishmaniasis (VL) and HIV enable earlier detection using less invasive methods. We report a case co-infected patient who had after VL treatment, where qualitative kDNA PCR showed good performance. The seems be useful tool may marker predicting treatment patients with clinical symptoms disease.
Using the indirect hemagglutination (IH), immunofluorescence (IIF) and enzyme linked immunosorbent assay (ELISA) tests for diagnosis of Chagas disease, 4000 serum samples were examined. This study was conducted with different purposes: clinical interest, research support parasitological monitoring those patients disease who treated heart transplantations. The occurred without patient selection in accordance medical requests. results showed discrepancies brought about several questions,...
The aim of this study was to evaluate whether the molecular (kDNA-PCR) and parasitological diagnosis in peripheral blood (PB) could replace invasive painful bone marrow collection (BM) visceral leishmaniasis (VL). PB from suspected VL patients evaluated by techniques using as gold standard (GS) a combination clinical, epidemiological, immunochromatographic test (PB-rK39) results examination BM. Based on GS, 38 samples 32 were grouped: Group 1, 20 cases, 2, 18 non-VL cases. In order PB,...
ABSTRACT. In situ and systemic evaluations of the immune responses HIV-infected patients to mucosal leishmaniasis have been poorly described. We describe a recently diagnosed patient with who was characterized by CD4 count 85 cells/mm 3 nasal septum destruction resulting from pruritic ulcerated mucosa crust formation progression over 2 years. T cell activation, memory, exhaustion were conducted using cytofluorometric assays, sequencing Leishmania species performed. The profile shows mixed...
Biomaterials comprise a scientific field where synthetic materials are developed for pertinent biological functions, yielding wide diversity of new products. Although widely employed, they still require improvement therapeutic purposes. The objective this study was to develop poly (N-2-vinyl-pyrrolidone) (PVP), (vinyl alcohol) (PVAl), clay, and N-methyl glucamine hydrogels the treatment cutaneous leishmaniasis. characterization techniques used were tumescence, energy-dispersive X-ray (EDX)...
The prevalence of infections by bovine leukosis virus in bovines the Fleckvieh breed raised at Sao Paulo State, Brazil, was investigated with glycoprotein antigen (gp 51) agar-gel immunodiffusion tests. overall antibodies 9.24 % (44/476); foci infection existed 85.71 (6/7) studied herds. samples arranged according to various age groups showed a higher older animals. values obtained were following: up 3 months – 0.00% (0/55); 3-6 (0/41); 6-12 1.07% (1/93); 12-24 4.49% (4/89); 24- 48 9.78%...
The immunosuppressive effect of methotrexate has rarely been associated with reactivation cutaneous leishmaniasis. Here we present a case leishmaniasis patient atypical clinical symptoms without splenomegaly but manifestations after treatment rheumatoid arthritis and blood recovery the parasite. Next-generation sequencing was used to identify Leishmania infantum chagasi in patient's sample.
Abstract Background COVID-19 disease (Coronavirus 2019) caused by SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) is widespread worldwide, affecting more than 11 million people globally (July 6 th , 2020). Diagnostic techniques have been studied in order to contain the pandemic. Immunochromatographic (IC) assays are feasible and low cost alternative for monitoring spread of population. Methods Here we evaluate sensitivity specificity eleven different immunochromatographic tests...
COVID-19 disease is spread worldwide and diagnostic techniques have been studied in order to contain the pandemic. Immunochromatographic (IC) assays are feasible a low-cost alternative especially low middle-income countries, which lack structure perform certain techniques. Here we evaluate sensitivity specificity of eleven different IC tests 145 serum samples from confirmed cases using RT-PCR 100 negative blood donors collected February 2019. We also evaluated cross-reactivity with dengue 20...