A5054521335- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Leprosy Research and Treatment
- Dermatological diseases and infestations
- Eosinophilic Disorders and Syndromes
- Fungal Infections and Studies
- Insect and Pesticide Research
- Parasites and Host Interactions
- Health, Nursing, Elderly Care
- Cutaneous lymphoproliferative disorders research
- Toxin Mechanisms and Immunotoxins
- Antifungal resistance and susceptibility
- Insect Pest Control Strategies
- History of Medicine and Tropical Health
- Leptospirosis research and findings
- Business and Management Studies
- Plant Pathogens and Fungal Diseases
- Contact Dermatitis and Allergies
- Beetle Biology and Toxicology Studies
- Health Systems, Economic Evaluations, Quality of Life
- Urticaria and Related Conditions
- Reproductive System and Pregnancy
- Infectious Diseases and Tuberculosis
- Race, Identity, and Education in Brazil
- Psychodrama and Leishmaniasis Studies
Fundação Oswaldo Cruz
2016-2025
Instituto Evandro Chagas
2014-2024
University of Lisbon
2021-2022
Universitat Pompeu Fabra
2021-2022
Universidad de Salamanca
2021-2022
Universidade de Santiago de Compostela
2021-2022
University of Milan
2021-2022
University of Bari Aldo Moro
2021-2022
Faculdades Oswaldo Cruz
2022
Universidade Federal Fluminense
2020
Background Treatment guidance for children and older adult patients affected by cutaneous leishmaniasis (CL) is unclear due to limited representation of these groups in clinical trials. Methods We conducted a collaborative retrospective study describe the effectiveness safety antileishmanial treatments ≤ 10 adults ≥ 60 years age, treated between 2014 2018 ten CL referral centers Latin America. Results 2,037 records were assessed eligibility. Of them, main reason non-inclusion was lack data...
Neutrophil extracellular traps (NETs) have been described as a network of fibers composed by DNA, histones and various proteins/enzymes. Studies demonstrated that NETs could be responsible for the trapping elimination variety infectious agents. In order to verify presence in American tegumentary leishmaniasis (ATL) their relationship with amastigotes we evaluated active cutaneous lesions 35 patients before treatment detection parasites, neutrophils (neutrophil elastase) through...
SUMMARY American tegumentary leishmaniasis (ATL) is an infectious disease caused by protozoa of the genus Leishmania, and transmitted sandflies. In state Rio de Janeiro, almost all cases are Leishmania (Viannia) braziliensis, while visceral (VL) (Leishmania) infantum chagasi. The resurgence autochthonous VL in Janeiro related to geographic expansion vector Lutzomyia longipalpis its ability adapt urban areas. We report first case with exclusively cutaneous manifestations L. (L.) chagasi area...
We evaluated the effectiveness and safety of intralesional meglumine antimoniate (MA) in 24 not submitted to previous treatment patients with cutaneous leishmaniasis (CL) contraindication systemic therapy. Each consisted one four applications MA at 15-day intervals. Patients' age ranged from 3 90 years; fourteen were females. Intralesional absence any relevant toxicity was successful 20 (83.3%) patients. Three required additional amphotericin B MA. None developed mucosal lesions when...
Cutaneous leishmaniasis (CL) is caused by Leishmania (Viannia) braziliensis, which infects dermal macrophages and dendritic cells, causing an intense immune-mediated-tissue inflammation a skin ulcer with elevated borders that can heal spontaneously or after antimonial therapy. The resolution of lesions depends on adaptive immune response, cytotoxic cells seem to have fundamental role in this process. aim study better understand the cytotoxicity mediated mechanisms occur during response CL...
A case-control study was conducted to examine the association among Montenegro skin test (MST), age of lesion and therapeutic response in patients with cutaneous leishmaniasis (CL) treated at Evandro Chagas National Institute Infectious Diseases (INI), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. For each treatment failure (case), two controls showing healing following treatment, paired by sex age, were randomly selected. All 5 mg Sb5+/kg/day intramuscular meglumine antimoniate...
Background Although high dose of antimony is the mainstay for treatment American cutaneous leishmaniasis (ACL), ongoing major concerns remain over its toxicity. Whether or not low regimens provide non-inferior effectiveness and lower toxicity has long been a question dispute. Methods A single-blind, non-inferiority, randomized controlled trial was conducted comparing with in subjects ACL treated at referral center Rio de Janeiro, an endemic area Leishmania (Viannia) braziliensis...
Sporotrichosis is usually caused by the traumatic inoculation of pathogenic species fungi genus Sporothrix. The most prevalent in Brazil Sporothrix brasiliensis, which generally associated with transmission involving infected cats. hyperendemic state Rio de Janeiro and Duque Caxias one affected municipalities.This was a cross-sectional, geo-epidemiological socioeconomic study human sporotrichosis municipality using geoprocessing information for construction thematic maps.Eight hundred...
Cutaneous leishmaniasis is a neglected tropical disease caused, in Brazil, mainly by Leishmania braziliensis, which protozoan transmitted during the blood feeding of infected female sandflies. To control leishmaniasis, participation CD4+ Th1 cells together with macrophages, neutrophils, and other peripheral cells, including platelets, necessary. These anuclear fragments, when activated, produce microvesicles (MVs) that can reach locations outside blood, carrying molecules responsible for...
This cross-sectional study describes the adequacy of nutritional status and food intake in patients with American Tegumentary Leishmaniasis its relationship form disease: cutaneous or mucosal. Patients mucosal have greater impairment associated older age symptoms such as odynophagia, dysphagia, oropharyngeal lesions, which lead to reduced dietary inadequate micronutrients. often experience malnutrition, weight loss, dehydration; however, their eating profile degree interference disease...
ABSTRACT Cutaneous leishmaniasis (CL) has substantial epidemiological and clinical differences depending on host characteristics, Leishmania species geographic areas. CL in Rio de Janeiro State was evaluated. Mandatory notifications of confirmed cases from 2001–2020 were analyzed considering sociodemographic variables, temporal trends, the Leishmaniasis Composite Indicator (CLCI) for each affected city relation to total cities state, triennium beginning end time series (2001–2003, 2002–2004...
Leishmaniasis is a group of important parasitic diseases affecting millions worldwide. To understand more clearly the quality T helper type 1 (Th1) response stimulated after Leishmania infection, we applied multiparametric flow cytometry protocol to evaluate multifunctional cells induced by crude antigen extracts obtained from promastigotes braziliensis (LbAg) and amazonensis (LaAg) in peripheral blood mononuclear healed cutaneous leishmaniasis patients. Although no significant difference...
American tegumentary leishmaniasis is an infectious disease caused by a protozoan of the genus Leishmania. Pentavalent antimonials are first choice drugs for cutaneous (CL), although doses controversial. In clinical trial CL we investigated occurrence pancreatic toxicity with different schedules treatment meglumine antimoniate (MA). Seventy-two patients were allocated in two therapeutic groups: 20 or 5 mg pentavalent antimony (Sb5+)/kg/day 30 days, respectively. Looking adverse effects,...
The purpose of this study was to establish a correlation between the endemic level tegumentary leishmaniasis in different regions Brazil during 2002–2009 and number cases mucosal or mucocutaneous leishmaniasis. proportion inversely correlated with prevalence infection. In areas lower infection prevalence, increased ( P < 0.05). hypothesis an Amazonian origin dissemination through human migration is considered. Our results show that endemically younger, evolve form higher than older.
BACKGROUND Cutaneous leishmaniasis (CL) generally presents with a single or several localised cutaneous ulcers without involvement of mucous membranes. Ulcerated lesions are susceptible to secondary contamination that may slow the healing process. OBJECTIVE This study verified influence non-parasitic wound infection on closure (epithelialisation) and total healing. METHODS Twenty-five patients confirmed diagnosis CL ulcerated underwent biopsy ulcer borders. One direct microbial parameter...
Sporotrichosis is a globally distributed subcutaneous fungal infection caused by dimorphic fungi belonging to the Sporothrix species complex that affects skin of limbs predominantly, but not exclusively. A rare case ocular sporotrichosis in an immunocompetent Brazilian patient from countryside Rio de Janeiro State reported. 68-year-old woman presented with subconjunctival infiltrative lesion right eye pre-auricular lymphadenopathy onset 4 months ago evolved suppurative nodular lesions on...
Intralesional treatment for cutaneous leishmaniasis has been applied over 30 years at the Oswaldo Cruz Foundation, Rio de Janeiro, with good therapeutic results and without relevant systemic toxicity.Meglumine antimoniate was injected subcutaneously, using a long medium-caliber needle (for example, 30mm × 0.8mm); patients received 1-3 injections, 15-day intervals.The technique is described in detail sufficient to enable replication.The of intralesional meglumine simple, effective, safe...
Background Atypical presentations of cutaneous leishmaniasis include sporotrichoid (SL), which is clinically described as a primary ulcer combined with lymphangitis and nodules and/or ulcerated lesions along its pathway. Aims To assess the differences between patients typical (CL). Methods From January 2004 to December 2010, 23 cases SL (4.7%) were detected among 494 CL diagnosed at reference center for disease in Rio de Janeiro State, Brazil. These compared remaining 471 presenting CL....
American tegumentary leishmaniasis (ATL) is a non-lethal parasitic disease that presents with cutaneous (CL) and mucosal (ML) clinical forms. ATL treatment aims at healing the lesions preventing development of late form. Systemic meglumine antimoniate (MA) therapy 10-20 mg Sb5+/kg/day first choice treatment. However, alternative therapies using 5 or intralesional (IL) MA are usual regimens National Institute Infectious Diseases (NIID), Rio de Janeiro, Brazil.To evaluate lethality incidence...
Summary Cutaneous leishmaniasis ( CL ) is an important public health issue worldwide. The control of Leishmania infection depends on cellular immune mechanisms, and the inflammatory response may contribute to pathogenesis. A beneficial role CD 8 + T lymphocytes has been proposed; nevertheless, other studies suggest a cytotoxic involved in tissue damage, showing controversial these cells. goal current study was understand immunopathology determine profile cells – such as 4 T, natural killer...
Background Cutaneous leishmaniasis (CL) is an infectious vector-borne disease caused by protozoa of the Leishmania genus that affects humans and animals. The distribution parasites in lesion not uniform, there are divergences literature about choice better sampling site for diagnosis–inner or outer edge ulcerated skin lesion. In this context, determining region with highest parasite density and, consequently, appropriate collecting samples can define success laboratory diagnosis. Hence,...
This is a case report of Brazilian soldier with cutaneous leishmaniasis. The lesion relapsed following two systemic treatments meglumine antimoniate. patient was treated amphotericin B, which interrupted due to poor tolerance. Following isolation Leishmania sp., six intralesional infiltrations antimoniate resulted in no response. sp promastigotes were again isolated. submitted intramuscular 4mg/kg pentamidine. Parasites from the first and second biopsies identified as (Viannia) braziliensis;...