A5059881072- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Celiac Disease Research and Management
- Peripheral Neuropathies and Disorders
- Electroconvulsive Therapy Studies
- Microscopic Colitis
- SARS-CoV-2 and COVID-19 Research
- Women's cancer prevention and management
- Insect and Pesticide Research
- Clostridium difficile and Clostridium perfringens research
- Infectious Encephalopathies and Encephalitis
- Long-Term Effects of COVID-19
- Autoimmune Neurological Disorders and Treatments
- RNA regulation and disease
- Dermatological diseases and infestations
- T-cell and Retrovirus Studies
- Family Support in Illness
- Brain Metastases and Treatment
- Cardiac Arrhythmias and Treatments
- Cardiovascular Health and Disease Prevention
- Inflammatory Bowel Disease
- Respiratory and Cough-Related Research
- Renal function and acid-base balance
- Cerebral Venous Sinus Thrombosis
- Retinal and Optic Conditions
Hospital Nacional Cayetano Heredia
2021-2024
Universidad El Bosque
2024
Universidad Peruana Cayetano Heredia
2010-2023
Instituto de Medicina Tropical
2020-2023
Western University
2023
Immunogenics (United States)
2023
Erasmus MC
2021
Johns Hopkins Medicine
2021
Johns Hopkins University
2021
United States Naval Medical Research Unit SOUTH
2021
To determine the frequency and significance of concurrent glial (glial-Ab) or neuronal-surface (NS-Ab) antibodies in patients with anti-NMDA receptor (NMDAR) encephalitis.Patients were identified during initial routine screening a cohort (C1) 646 consecutively diagnosed anti-NMDAR encephalitis another (C2) 200 systematically rescreened. Antibodies determined rat brain immunostaining cell-based assays.Concurrent 42 (4% from C1 7.5% C2): 30 (71%) glial-Ab 12 (29%) NS-Ab. Glial-Ab included...
Traditional detection of Leishmania from ulcers involves collection invasive specimens that cause discomfort, require technical expertise, and carry risks procedures. We compared traditional diagnostic methods with a molecular noninvasive filter paper-based method for the diagnosis cutaneous leishmaniasis.Consecutive patients presenting to Clinic at Hospital Nacional Cayetano Heredia were enrolled. Polymerase chain reaction (PCR) was performed on lesion scrapings, aspirates, paper...
<h3>Objective</h3> To identify the clinical phenotypes and infectious triggers in 2019 Peruvian Guillain-Barré syndrome (GBS) outbreak. <h3>Methods</h3> We prospectively collected neurophysiologic data of patients with GBS admitted to a tertiary hospital Lima, Peru, between May August 2019. Molecular, immunologic, microbiological methods were used causative agents. Sera from 41 controls compared cases for antibodies <i>Campylobacter jejuni</i> gangliosides. Genomic analysis was performed on...
Background Treatment guidance for children and older adult patients affected by cutaneous leishmaniasis (CL) is unclear due to limited representation of these groups in clinical trials. Methods We conducted a collaborative retrospective study describe the effectiveness safety antileishmanial treatments ≤ 10 adults ≥ 60 years age, treated between 2014 2018 ten CL referral centers Latin America. Results 2,037 records were assessed eligibility. Of them, main reason non-inclusion was lack data...
American Tegumentary Leishmaniasis (ATL) is an endemic and neglected disease of South America. Here, mucosal leishmaniasis (ML) disproportionately affects up to 20% subjects with current or previous localised cutaneous (LCL). Preclinical clinical reports have implicated the Leishmania RNA virus-1 (LRV1) as a possible determinant progression ML other severe manifestations such extensive treatment failure relapse. However, these associations were not consistently found in observational studies...
Background Traditional methods of diagnosing mucosal leishmaniasis (ML), such as biopsy with histopathology, are insensitive and require collection an invasive diagnostic specimen. Methods We compared standard procedures including PCR, leishmanin skin test (LST) to a novel, non-invasive, cytology-brush based PCR for the diagnosis ML in Lima, Peru. Consensus reference was 2/4 tests positive, outcome measures were sensitivity specificity. Leishmania species identification performed by...
We hypothesized that Leishmania kDNA may be present in urine of patients with cutaneous leishmaniasis (CL). Urine samples and standard diagnostic specimens were collected from skin lesions. polymerase chain reaction (PCR) was performed on 10 healthy volunteers non-endemic areas. Eighty-six 108 diagnosed CL 18 (21%) had detectable Viannia the urine. Sensitivity specificity 20.9% (95% confidence interval [CI] 12.3–29.5%) 100%. Six 8 mucocutaneous involvement versus 12 78 isolated disease ( P...
Background Systemic pentavalent antimonials, mainly meglumine antimoniate, continue to be the first-choice drugs for treatment of cutaneous leishmaniasis (CL) despite their toxicity, difficulty administration and high cost. In search therapeutic alternatives, combining two interventions has emerged as a potential alternative either reduce use antimonials with associated toxicities, or increase efficacy. Here, we report results recently completed trial assessing efficacy safety combination...
We compared traditional cutaneous leishmaniasis diagnostic methods to filter paper lesion impression (FPLI) PCR for secondarily infected ulcers and nonulcerative lesions. The sensitivity specificity of FPLI lesions (n = 8) were 100%. In primarily 15), the was inferior that pooled-invasive-specimen (72.7% versus 100%) (P 0.10). is sensitive, specific, unlike invasive procedures, can be used in ulcers. Invasive specimen collection superior
Background Cutaneous leishmaniasis (CL) is a neglected disease and public health problem in Latin America. The diagnosis of CL poor hyperendemic regions relies to large extent on the identification amastigotes Giemsa-stained smears. There an urgent need for rapid, sensitive low cost diagnostic method use field conditions as current modalities are not readily available. primary objective this study was determine sensitivity specificity FDA-cleared Detect Rapid Test Peru, using modified test...
In 2018/2019, two large Guillain–Barré Syndrome (GBS) outbreaks took place in Peru. Here, we report a comprehensive analysis of biological samples from GBS patients the 2019 outbreak. We applied metagenomic, microbiologic, and serological analyses to different collected patients. Further phenotypic genomic characterization was conducted on Campylobacter jejuni isolates samples. Microbiologic metagenomic revealed several with multiple co-infections, yet no common infectious agents were found...
Background: American tegumentary leishmaniasis (ATL) is a neglected disease of South America where metastatic mucosal lesions (ML) can be seen in up to 5-20% Leishmania Viannia complex infections. The RNA virus-1 (LRV1) has been recently implicated as possible pathogenic agent ATL since disseminated (DisL) was induced by high LRV1-expressing amastigotes an animal model, and human cases DisL have reportedly infected with LRV1-containing parasites. None these studies clearly supported its role...
The clinical course of oligodendroglial tumors is variable and there a lack consensus with regard to precisely diagnose which minimal criteria are required make diagnosis high-grade oligodendrial tumor. aims the present study assess pathologic factors prognostic significance, in addiction neuroradiologic variables, an attempt identify reproducible histological parameters that useful for classification tumors.80 diagnosed between 1977 2004 were analyzed. To anaplastic tumor we used...
En áreas endémicas de leishmaniasis cutánea es común que los pacientes manipulen sus lesiones con tratamientos tradicionales como primera opción terapéutica. Con el objetivo describir la frecuencia y cambios manipulación en Hospital Cayetano Heredia, se realizó un estudio tipo serie casos. Se incluyeron 124 cutánea. El 54% (67/124) manipuló lesiones; 92,5% (62/67) lo hizo productos químicos, 43,3% (29/67), plantas. Los locales más frecuentemente reportados por fueron aumento tamaño lesión...
Serologic measures of tissue transglutaminase (tTG) immunoglobulin A (IgA) and deamidated gliadin peptide (DGP) IgA G (IgG) are hallmark tests utilized when diagnosing individuals for celiac disease (CeD) monitoring adherence to a gluten-free diet (GFD), currently the only available treatment CeD. We address two issues in this study: (i) relapse seropositivity CeD patients who resume gluten containing (ii) correlation between different tTG-IgA assays near upper limit normal (ULN) designated...
Abstract Background Accumulating evidence shows that the development of IBD is always accompanied by dysbiosis intestinal microbiota. Short-chain fatty acids (SCFAs) are produced prebiotic bacteria, with mportant anti-inflammatory functions, delaying clinical progression IBD. The aim this study to compare SCFA levels in fecal matter patients versus Spondyloarthritis (SpA) and healthy controls. Methods 24 were evaluated for presence gastrointestinal symptoms, demographic data inflammatory...
A cirurgia minimamente invasiva tem ganhado destaque no tratamento de diversas condições médicas por conta suas vantagens, tais como menor trauma cirúrgico, recuperação mais ágil e resultados estéticos superiores. Essa estratégia atraído cada vez atenção nas cardiopatias congênitas infantis. Neste cenário, o propósito deste estudo é conduzir uma revisão sistemática para avaliar a efetividade segurança da técnica empregada envolveu pesquisa bases dados PubMed, Cochrane Library SciELO,...
O aborto e o câncer ginecológico é visto como uma questão complexa de saúde pública, afetando diretamente os aspectos psicossociais das mulheres que enfrentam essa situação, além gerar altos índices mortalidade despesas para setor público. As consequências psicológicas do pós-parto se manifestam através sentimentos tristeza, arrependimento culpa. Assim objetivou-se descrever as repercussões vivenciadas por no pós- aborto. Tratou-se revisão integrativa com delineamento qualitativo,...