A5060350360- Leprosy Research and Treatment
- Psoriasis: Treatment and Pathogenesis
- Viral Infections and Vectors
- Ocular Diseases and Behçet’s Syndrome
- Mycobacterium research and diagnosis
- Extracellular vesicles in disease
- Research on Leishmaniasis Studies
- Cytomegalovirus and herpesvirus research
Fundação Oswaldo Cruz
2021-2025
Cutaneous leishmaniasis is a neglected tropical disease caused, in Brazil, mainly by Leishmania braziliensis, which protozoan transmitted during the blood feeding of infected female sandflies. To control leishmaniasis, participation CD4+ Th1 cells together with macrophages, neutrophils, and other peripheral cells, including platelets, necessary. These anuclear fragments, when activated, produce microvesicles (MVs) that can reach locations outside blood, carrying molecules responsible for...
Abstract Leprosy is a neglected chronic infectious disease caused by Mycobacterium leprae or M. lepromatosis, representing public health concern in several low-income countries. In Brazil, most patients develop lepromatous leprosy, clinical form characterized poor bacillary control due to T helper 2 cells, M2 macrophages, and accentuated humoral immunity. Despite extensive studies, the complete mechanism of not fully understood. The evasion mechanisms used pathogen likely involve cellular...
Leprosy reactions are an acute and systemic manifestation, which occurs suddenly, can be severe lead leprosy patients to disability. Reactional episodes observed among half of the multibacillary patients, mainly in borderline lepromatous forms. They may begin at any time during multidrug therapy, even before treatment. Physical disabilities, source extreme suffering pain for occur progression cellular immune response associated with a reaction still poorly understood. Thus, this work aimed...
Leprosy is an infectious disease that remains endemic in approximately 100 developing countries, where about 200,000 new cases are diagnosed each year. Moreover, multibacillary leprosy, the most contagious form of disease, has been detected at continuously higher rates among Brazilian elderly people. Due to so-called immunosenescence, characterized by several alterations quality immune response during aging, this group more susceptible diseases. In view such data, purpose our work was...
Background Leprosy continues to be a public health problem in Brazil. Furthermore, detection rates elderly people have increased, particularly those of multibacillary (L-Lep) patients, who are responsible for transmitting M . leprae Part the decline physiological function during aging is due increased oxidative damage and change T cell subpopulations, which critical defense against disease. It not still clear how age-related changes like related oxidation affect with leprosy. The aim this...