Sporotrichosis is endemic in Rio de Janeiro, Brazil, and cases have been reported to be associated with HIV. This article describes the clinical manifestations evolution of sporotrichosis HIV-positive patients constitutes largest case series date. There were 21 diagnosed by recovery etiologic agent from 1999–2009. Sixteen (76.2%) men five (23.8%) women, a mean age 41.2 years. Seven these individuals previously unaware their HIV infection. Mean CD4 count was 346.4 cells/μl. The most frequent...

Covid-19 is a novel infectious disease whose spectrum of presentation ranges from absence symptoms to widespread interstitial pneumonia associated with severe acute respiratory syndrome (SARS), leading significant mortality. Given the systemic pattern Covid-19, there are many factors that can influence patient's functional capacity after infection and identification such contribute development specific rehabilitation strategies. Pulmonary impairment primary cause hospitalization due progress...

Diffuse cutaneous leishmaniasis (DCL) is characterised by multiple and progressive lesions, resistance to chemotherapy Leishmania-specific T-cell anergy. We report the first autochthonous DCL case human infection with Leishmania amazonensis in Rio de Janeiro State, Brazil, where only L. braziliensis considered be causative agent of leishmaniasis. was identified multilocus enzyme electrophoresis PCR-RFLP. Our diagnosed as according clinical, parasitological, histopathological immunological...

Although rare, disseminated sporotrichosis is increasing in several countries. Despite its limiting toxic potential, amphotericin B the only intravenous antifungal available to treat severe sporotrichosis. We aimed describe effectiveness and safety of treatment for Clinical records patients with at a reference center were reviewed. This study included 73 patients. Most (53.4%) men non-white. HIV coinfection was main comorbidity (52.1%). reported contact cats (76.7%). Sporothrix brasiliensis...

Apesar da alta prevalência entre idosos, a perda auditiva é pouco investigada. A audiometria o teste padrão ouro para avaliação de auditiva, mas sua realização em larga escala traz dificuldades operacionais. O auto-relato pode ser uma alternativa. OBJETIVO: Determinar se única questão genérica tem validade utilizada pesquisas epidemiológicas. FORMA DE ESTUDO:Revisão sistemática. MATERIAL E MÉTODO: Foi realizada pesquisa literatura médica nas bases dados MEDLINE e LILACS, no período 1990...

Background The study of American tegumentary leishmaniasis (ATL) lesions might contribute to the understanding dynamics infection. Objectives To examine cellular infiltrate cutaneous ATL and compare these results with detection parasites clinical data. Methods Lesions 19 patients were evaluated through immunohistochemical analysis. Results presented an inflammatory reaction mainly consisting T cells macrophages. Analysis expression nitric oxide synthase type 2 (NOS2) showed that its...

The present study investigated the diagnostic value of polymerase chain reaction (PCR) performed in parallel to conventional methods at an American tegumentary leishmaniasis (ATL) referral centre for diagnosis. Accuracy parameters PCR were calculated using 130 patients with confirmed ATL (ATL group), 15 established other diseases and 23 a lesion suggestive ATL, but without parasitological confirmation (NDEF group). showed 92.3% sensitivity, 93.3% specificity, 99.2% positive predictive 13.84...

We evaluated the effectiveness and safety of intralesional meglumine antimoniate (MA) in 24 not submitted to previous treatment patients with cutaneous leishmaniasis (CL) contraindication systemic therapy. Each consisted one four applications MA at 15-day intervals. Patients' age ranged from 3 90 years; fourteen were females. Intralesional absence any relevant toxicity was successful 20 (83.3%) patients. Three required additional amphotericin B MA. None developed mucosal lesions when...

Introduction Laryngeal tuberculosis (LTB) is the most frequent granulomatous disease of larynx and represents less than 2% extrapulmonary TB cases. There are no pathognomonic clinical endoscopic features this studies on LTB that can assist in its diagnostic characterization lacking. Objective To identify factors associated with topographical LTB. Method a retrospective cross-sectional study was conducted from medical records 36 patients confirmed diagnosis. Results Dysphonia cough were main...

Background Although high dose of antimony is the mainstay for treatment American cutaneous leishmaniasis (ACL), ongoing major concerns remain over its toxicity. Whether or not low regimens provide non-inferior effectiveness and lower toxicity has long been a question dispute. Methods A single-blind, non-inferiority, randomized controlled trial was conducted comparing with in subjects ACL treated at referral center Rio de Janeiro, an endemic area Leishmania (Viannia) braziliensis...

This cross-sectional study describes the adequacy of nutritional status and food intake in patients with American Tegumentary Leishmaniasis its relationship form disease: cutaneous or mucosal. Patients mucosal have greater impairment associated older age symptoms such as odynophagia, dysphagia, oropharyngeal lesions, which lead to reduced dietary inadequate micronutrients. often experience malnutrition, weight loss, dehydration; however, their eating profile degree interference disease...

American tegumentary leishmaniasis (ATL) can affect the skin or mucosa (mucocutaneous - MCL) including oral cavity. MCL lesions are often confused with other diseases, delaying diagnosis and specific treatment, increasing likelihood of sequelae. Thus, knowledge evolution ATL facilitate its early improving prognosis healing.Evaluate frequency lesion describe clinical, laboratory therapeutic peculiarities.A descriptive transversal study was carried out, using data from medical records 206...

American tegumentary leishmaniasis is an infectious disease caused by a protozoan of the genus Leishmania. Pentavalent antimonials are first choice drugs for cutaneous (CL), although doses controversial. In clinical trial CL we investigated occurrence pancreatic toxicity with different schedules treatment meglumine antimoniate (MA). Seventy-two patients were allocated in two therapeutic groups: 20 or 5 mg pentavalent antimony (Sb5+)/kg/day 30 days, respectively. Looking adverse effects,...

The purpose of this study was to establish a correlation between the endemic level tegumentary leishmaniasis in different regions Brazil during 2002–2009 and number cases mucosal or mucocutaneous leishmaniasis. proportion inversely correlated with prevalence infection. In areas lower infection prevalence, increased ( P < 0.05). hypothesis an Amazonian origin dissemination through human migration is considered. Our results show that endemically younger, evolve form higher than older.

Abstract Background The genetic variability of Leishmania ( Viannia ) braziliensis was assessed at intra and interpatient levels individuals with different clinical manifestations American tegumentary leishmaniasis (ATL). Methods Fifty-two samples, which 13 originated from cutaneous lesions 39 mucosal lesions, provided by 35 patients, were examined low-stringency single-specific-primer PCR (LSSP-PCR) phenetic analysis. Genetic L . V .) , in kinetoplast DNA (kDNA) signatures, compared both...

Intralesional treatment for cutaneous leishmaniasis has been applied over 30 years at the Oswaldo Cruz Foundation, Rio de Janeiro, with good therapeutic results and without relevant systemic toxicity.Meglumine antimoniate was injected subcutaneously, using a long medium-caliber needle (for example, 30mm × 0.8mm); patients received 1-3 injections, 15-day intervals.The technique is described in detail sufficient to enable replication.The of intralesional meglumine simple, effective, safe...

Background Atypical presentations of cutaneous leishmaniasis include sporotrichoid (SL), which is clinically described as a primary ulcer combined with lymphangitis and nodules and/or ulcerated lesions along its pathway. Aims To assess the differences between patients typical (CL). Methods From January 2004 to December 2010, 23 cases SL (4.7%) were detected among 494 CL diagnosed at reference center for disease in Rio de Janeiro State, Brazil. These compared remaining 471 presenting CL....

Introduction Laryngeal tuberculosis (LTB) is the most frequent larynx granulomatous disease. In general there lung involvement, but in an important proportion of cases you can find LTB without pulmonary The lesions observed LTB, such as ulceration and fibrosis, interfere process voice production. involvement mucous lining vocal folds change their flexibility and, consequently, quality, main symptom dysphonia present almost 90% cases. Objective To describe anatomical characteristics quality...

American tegumentary leishmaniasis (ATL) is a non-lethal parasitic disease that presents with cutaneous (CL) and mucosal (ML) clinical forms. ATL treatment aims at healing the lesions preventing development of late form. Systemic meglumine antimoniate (MA) therapy 10-20 mg Sb5+/kg/day first choice treatment. However, alternative therapies using 5 or intralesional (IL) MA are usual regimens National Institute Infectious Diseases (NIID), Rio de Janeiro, Brazil.To evaluate lethality incidence...

Skin inflammation plays an important role during the healing of American tegumentary leishmaniasis (ATL), distribution cells in active lesions may vary according to disease outcome and parasite antigens ATL scars have already been shown. We evaluated by immunohistochemistry, 18 patients with 1- or 3-year-old corresponding compared them healthy skin. Small cell clusters organized as spreaded over fibrotic tissue were detected, well close vessels cutaneous glands, despite a reduction...