A5069926355- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Syphilis Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Parasites and Host Interactions
- Global Maternal and Child Health
- Antibiotics Pharmacokinetics and Efficacy
- Fungal Infections and Studies
- Zoonotic diseases and public health
- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- HIV/AIDS oral health manifestations
- Leprosy Research and Treatment
- Streptococcal Infections and Treatments
- Maternal and Neonatal Healthcare
- HIV-related health complications and treatments
- Infectious Diseases and Mycology
- Antifungal resistance and susceptibility
- Machine Learning in Healthcare
- HIV/AIDS drug development and treatment
- Viral Infections and Vectors
Fundação de Medicina Tropical
2016-2025
Universidade do Estado do Amazonas
2016-2025
Universidade Nilton Lins
2015-2025
Universidade Federal do Amazonas
2014-2025
Amazon (United States)
2025
South African Tuberculosis Vaccine Initiative
2024
University of Cape Town
2024
Universidade Salvador
2023
Instituto Evandro Chagas
2023
Vanderbilt University
2023
Betina Durovni and colleagues evaluated whether implementation of Xpert MTB/RIF increased the notification rate laboratory-confirmed pulmonary tuberculosis reduced time to treatment initiation in 14 Brazilian primary care laboratories. Please see later article for Editors' Summary
Mycobacterium tuberculosis infection is thought to induce oxidative stress. N-acetyl-cysteine (NAC) widely used in patients with chronic pulmonary diseases including due its mucolytic and anti-oxidant activities. Here, we tested whether NAC exerts a direct antibiotic activity against mycobacteria. Oxidative stress status plasma was compared between TB (PTB) those latent M. (LTBI) or healthy uninfected individuals. Lipid peroxidation, DNA oxidation cell death, as well accumulation of reactive...
Cellular necrosis during Mycobacterium tuberculosis (Mtb) infection promotes both immunopathology and bacterial dissemination. Glutathione peroxidase-4 (Gpx4) is an enzyme that plays a critical role in preventing iron-dependent lipid peroxidation–mediated cell death (ferroptosis), process previously implicated the necrotic pathology seen Mtb-infected mice. Here, we document altered GPX4 expression, glutathione levels, peroxidation patients with active assess of this pathway mice genetically...
Background Secondary bacterial infections from snakebites contribute to the high complication rates that can lead permanent function loss and disabilities. Although common in endemic areas, routine empirical prophylactic use of antibiotics aiming prevent secondary infection lacks a clearly defined policy. The aim this work was estimate efficacy amoxicillin clavulanate for reducing incidence patients bitten by Bothrops snakes, and, secondarily, identify risk factors Western Brazilian Amazon....
Abstract Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, transcription factor that represses multiple antioxidant genes, regulates host resistance to Mtb. found BACH1 expression is associated clinically with active pulmonary tuberculosis. Bach1 deletion Mtb-infected mice increased glutathione levels Gpx4 inhibit...
This study analyzes notification of syphilis in pregnancy and congenital Amazo- nas State, Brazil, from 2007 to 2009 verifies underreporting databases the National Information System on Diseases Notification (SINAN) occurrence perinatal deaths associated with not reported Mortality (SIM). was a cross-sectional probabilistic record linkage between SINAN SIM. There were 666 reports pregnant women, including 224 (3.8/1,000), 244(4.5/1,000) 2008, 198(4.0/1,000) 2009. The found 486 cases...
Introduction The impact on treatment outcomes of XpertMTB/RIF, a molecular-based test that provides rapid diagnosis tuberculosis (TB) and rifampicin resistance with high accuracy, has not been reported despite its adoption in few countries. We here report step-wedged cluster randomized trial for patients diagnosed XpertMTB/RIF compared to sputum smear examination public health facilities Brazil. Methods Treatment outcome data were added the database from 4 February October 2012, crosschecked...
The high burden of drug-resistant tuberculosis (TB) is a problem to achieve the goals End TB Strategy by 2035. Whether isoniazid monoresistance (Hr) affects anti-TB treatment (ATT) outcomes remains unknown in high-burden countries.
Abstract There are insufficient predictors of progression to tuberculosis among contacts. A case-control study within RePORT-Brazil matched 20 QuantiFERON-positive progressors and 40 non-progressors by sex, age, exposure duration. Twenty-nine cytokines were measured Luminex in QuantiFERON-TB Gold Plus supernatants collected at baseline evaluated using machine learning for prediction. The same markers 8 QuantiFERON positive 12 from India. IL-8, IL-10, CCL3 levels predicted incident (AUC:...
Background: Tuberculosis (TB) remains a leading cause of infectious disease mortality globally. Although directly observed therapy (DOT) has been widely implemented to improve adherence, nonadherence continues compromise treatment success rates, especially in real-world settings. Therefore, this study aims assess the impact missed doses on TB outcomes.Methods: prospective observational cohort that followed participants for two years after initiation at five clinical centers Salvador, Rio de...
Although genetic factors contribute to tuberculosis (TB) risk, no cross-population causal variants have been identified by genome-wide association studies (GWAS). Here, we utilized low-pass whole genome sequencing (lpWGS) with imputation plus detailed epidemiologic risk and single-cell expression quantitative loci (sceQTL) address prior GWAS limitations. Using 947 pulmonary (PTB) cases 1807 close contact controls in the Regional Prospective Observational Research TB (RePORT) study Brazil,...
<sec><title>BACKGROUND</title>Truenat™ is a WHO-recommended rapid molecular test for diagnosing TB and detecting rifampicin resistance, whose performance has been evaluated in few high burden countries.</sec><sec><title>METHODS</title>A prospective multicentre study was conducted Brazil to estimate the sensitivity specificity of Truenat MTB Plus compared Xpert ® MTB/RIF Ultra pulmonary TB. Liquid culture Mycobacterium tuberculosis drug susceptibility...
The World Health Organization has endorsed the Xpert MTB/RIF (Xpert), an automated polymerase-chain-reaction-based assay, for rapid diagnosis of tuberculosis. However, large-scale use a new technology calls preparation and adaptation.A pilot implementation study was conducted in two Brazilian cities to explore replacement sputum smear microscopy with Xpert. laboratories included covered 70% tuberculosis cases diagnosed, had no overlap population catchment areas, handled different workloads...
BackgroundA major goal of tuberculosis (TB) epidemiological studies is to obtain results that can be generalized the larger population with TB. The ability extrapolate findings on determinants TB treatment outcomes also important.MethodsWe compared baseline clinical and demographic characteristics anti-TB between persons enrolled in Regional Prospective Observational Research Tuberculosis (RePORT)-Brazil cohort June 2015 2019, registry cases reported Brazilian National Program (Information...
Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity anemia in PWTB prior to anti-TB treatment (ATT) was risk factor for an unfavorable outcome.
Tuberculosis elimination requires treatment of latently infected high-risk persons, such as contacts index cases. Identification and referral tuberculosis for investigation are major barriers in the contact cascade-of-care. These tasks rely heavily on auxiliary primary healthcare workers many low- middle-income countries. We aimed to understand their knowledge, attitudes practices (KAP) regarding Brazil.We conducted a cross-sectional KAP survey transmission prevention among 135 three...
To identify factors predictive of mortality in patients admitted to the ICU with tuberculosis (TB)/HIV coinfection Manaus, Amazon Region.This was a retrospective cohort study TB/HIV coinfected over 18 years age who were an city Brazil, between January 2011 and December 2014. Sociodemographic, clinical, laboratory variables assessed. mortality, we employed Cox proportional hazards model.During period, 120 ICU. The mean 37.0 ± 11.7 years. Of evaluated, 94 (78.3%) died 62 (66.0%) those deaths...
It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB).
Tuberculosis (TB) still causes significant morbidity and mortality worldwide, especially in persons living with human immunodeficiency virus (HIV). This disease is hallmarked by persistent oxidative stress systemic inflammation. N-acetylcysteine (NAC), a glutathione (GSH) precursor, has been shown experimental models to limit Mycobacterium tuberculosis infection both suppression of the host response through direct antimicrobial activity. In recent phase II randomized clinical trial...
Abstract Background The Xpert MTB/RIF rapid molecular test provides a quantitative measure of Mycobacterium tuberculosis (Mtb) DNA in the form cycle threshold (Ct) values. This information can be translated into mycobacterial load and used as potential risk bacterial spread for (TB) cases, which impact infection control. However, role Ct values assessing Mtb transmission to close contacts has not yet been demonstrated. Methods A prospective study was performed investigate association between...
Tuberculosis contacts are candidates for active and latent tuberculosis infection screening eventual treatment. However, many losses occur in the different steps of contacts' cascade care. Reasons this poorly understood.To describe where contact to explore knowledge attitudes regarding transmission/prevention perceptions about services order understand reasons from service users' perspective.We collected routine data index case registry books patients' records build care 12 health facilities...
Despite the availability of effective antimicrobials, tuberculosis (TB) is still a serious health threat. Mortality even higher in people living with HIV who are diagnosed TB. New therapies needed to shorten time required cure TB and decrease fatality rates this population. N-acetylcysteine (NAC) glutathione precursor has shown recently experimental setting present vitro vivo anti-mycobacterial activity. We test hypothesis that NAC safe, well tolerated secondarily efficacious as adjunctive...