A5019691952- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Pharmacological Effects and Toxicity Studies
- Innovations in Medical Education
- HIV-related health complications and treatments
- Pharmacovigilance and Adverse Drug Reactions
- Advances in Oncology and Radiotherapy
- Iron Metabolism and Disorders
- HIV Research and Treatment
- Malaria Research and Control
- Chronic Disease Management Strategies
- Mosquito-borne diseases and control
- Blood groups and transfusion
- Pregnancy and Medication Impact
- Health and Medical Research Impacts
- Vitamin D Research Studies
- RNA modifications and cancer
- Health Education and Validation
- Maternal and Neonatal Healthcare
- Machine Learning in Healthcare
- Healthcare professionals’ stress and burnout
Fundação Oswaldo Cruz
2020-2025
Universidade Federal da Bahia
2018-2024
Faculdade de Tecnologia e Ciências
2022-2024
Universidade Salvador
2023
Escola Bahiana de Medicina e Saúde Pública
2023
Instituto Evandro Chagas
2023
Vanderbilt University
2023
Fundação Faculdade de Medicina
2021
Hospital Ana Nery
2021
Universidade de São Paulo
2019-2021
Despite major global efforts to eliminate tuberculosis, which is caused by Mycobacterium tuberculosis (Mtb), this disease remains as a plague of humanity. Several factors associated with the host and Mtb interaction favor infection establishment and/or determine progression. The Early Secreted Antigenic Target 6 kDa (ESAT-6) one most important well-studied mycobacterial virulence factors. This molecule has been described play an role in development tuberculosis-associated pathology...
The high burden of drug-resistant tuberculosis (TB) is a problem to achieve the goals End TB Strategy by 2035. Whether isoniazid monoresistance (Hr) affects anti-TB treatment (ATT) outcomes remains unknown in high-burden countries.
Abstract There are insufficient predictors of progression to tuberculosis among contacts. A case-control study within RePORT-Brazil matched 20 QuantiFERON-positive progressors and 40 non-progressors by sex, age, exposure duration. Twenty-nine cytokines were measured Luminex in QuantiFERON-TB Gold Plus supernatants collected at baseline evaluated using machine learning for prediction. The same markers 8 QuantiFERON positive 12 from India. IL-8, IL-10, CCL3 levels predicted incident (AUC:...
BackgroundA major goal of tuberculosis (TB) epidemiological studies is to obtain results that can be generalized the larger population with TB. The ability extrapolate findings on determinants TB treatment outcomes also important.MethodsWe compared baseline clinical and demographic characteristics anti-TB between persons enrolled in Regional Prospective Observational Research Tuberculosis (RePORT)-Brazil cohort June 2015 2019, registry cases reported Brazilian National Program (Information...
<h3>Importance</h3> The association of elevated levels specific inflammatory markers during pregnancy with adverse birth outcomes and infant growth could indicate pathways for potential interventions. <h3>Objective</h3> To evaluate whether higher certain are associated preterm (PTB), low weight (LBW), deficits. <h3>Design, Setting, Participants</h3> In this cohort study pregnant women or without HIV, 218 mother-infant pairs were followed up from through 12 months post partum June 27, 2016,...
Standard anti-tuberculosis treatment is highly effective, but a great challenge the management of adverse drug reactions (ADR). Our study aimed to characterize ADR according type, severity and time occurrence. A prospective tuberculosis (TB) cohort has been followed, from 2010 2016, at reference center in Rio de Janeiro, Brazil. Clinical laboratory tests information were collected all visits. described affected organ/system, classified as clinical and/or laboratory, early (first 2 months) or...
Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity anemia in PWTB prior to anti-TB treatment (ATT) was risk factor for an unfavorable outcome.
It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB).
Tuberculosis (TB) still causes significant morbidity and mortality worldwide, especially in persons living with human immunodeficiency virus (HIV). This disease is hallmarked by persistent oxidative stress systemic inflammation. N-acetylcysteine (NAC), a glutathione (GSH) precursor, has been shown experimental models to limit Mycobacterium tuberculosis infection both suppression of the host response through direct antimicrobial activity. In recent phase II randomized clinical trial...
Abstract Background The Xpert MTB/RIF rapid molecular test provides a quantitative measure of Mycobacterium tuberculosis (Mtb) DNA in the form cycle threshold (Ct) values. This information can be translated into mycobacterial load and used as potential risk bacterial spread for (TB) cases, which impact infection control. However, role Ct values assessing Mtb transmission to close contacts has not yet been demonstrated. Methods A prospective study was performed investigate association between...
Tuberculosis (TB) is associated with systemic inflammation and anemia, which are aggravated in persons living HIV (PLWH). Here, we characterized the dynamics of hemoglobin levels PLWH coinfected TB undergoing antitubercular therapy (ATT). We also examined relationships between anemia inflammatory disturbance as well association persistent unfavorable clinical outcomes. Data on several blood biochemical parameters cell counts were retrospectively analyzed a cohort 256 TB/HIV patients from...
Background Biomarkers of unfavourable tuberculosis (TB) treatment outcomes are needed to accelerate new drug and regimen development. Whether plasma cytokine levels can predict TB is unclear. Methods We identified internally validated the association between 20 a priori selected inflammatory markers failure, recurrence all-cause mortality among adults with drug-sensitive pulmonary in India. externally these findings two independent cohorts predominantly diabetic HIV co-infected patients...
Background Adverse drug reactions (ADR) challenge successful anti-tuberculosis treatment (ATT). The aim of this study was to evaluate the impact ATT-associated ADR and related factors on ATT outcomes. Methods A prospective cohort persons with tuberculosis (TB) at a referral center in Rio de Janeiro, Brazil, from 2010 2016. Baseline information: race, sex, schooling, economic status, tobacco, drugs alcohol abuse, HIV-infection status comorbidities were captured during TB screening diagnosis....
Introduction Anemia frequently affects people living with HIV (PLHIV). Nevertheless, the impact of anemia on treatment outcomes patients HIV-associated tuberculosis (TB) and underlying molecular profiles are not fully characterized. The aim this study was to investigate interplay between anemia, systemic inflammatory profile, dissemination TB death in HIV-TB an ad hoc analysis results from a prospective cohort study. Methods 496 hospitalized PLHIV ≥18 years old, CD4 count &lt;350...
Co-expression analysis has been widely used to elucidate the functional architecture of genes under different biological processes. Such analysis, however, requires substantial knowledge about programming languages and/or bioinformatics skills. We present webCEMiTool, a unique online tool that performs comprehensive modular analyses in fully automated manner. The webCEMiTool not only identifies co-expression gene modules but also several on them. In addition, integrates transcriptomic data...
Approximately 1.4 million people die annually worldwide from tuberculosis. Large epidemiologic studies can identify determinants of unfavorable clinical outcomes according to age, which guide public health policy implementation and management improve outcomes. We obtained data the national tuberculosis case registry; were reported Brazilian National Program (SINAN) between 2010 2019. Clinical variables compared age groups (child: <10 years, young: 10-24years, adult: 25-64years, elderly:...
Tuberculosis-diabetes mellitus (TB-DM) is linked to a distinct inflammatory profile, which can be assessed using multi-omics analyses. Here, machine learning algorithm was applied multi-platform data, including cytokines and gene expression in peripheral blood eicosanoids urine, Brazilian multi-center TB cohort. There were four clinical groups: TB-DM(n = 24), only(n 28), DM(HbA1c ≥ 6.5%) 11), control group of close contacts who did not have or DM(n 13). After cross-validation, baseline...
It is unknown whether dysglycemia associated with Mycobacterium tuberculosis transmission.We assessed epidemiological and clinical characteristics of patients culture-confirmed pulmonary their close contacts, enrolled in a multicenter prospective cohort Brazil. Contacts were investigated at baseline 6 months after enrollment. QuantiFERON positivity conversion (from negative to positive month 6) compared between subgroups contacts according glycemic status persons (PWTB) as diabetes mellitus...