A5081836499- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
- Mosquito-borne diseases and control
- Mycobacterium research and diagnosis
- Leptospirosis research and findings
- Viral Infections and Vectors
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune responses and vaccinations
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 detection and testing
- Essential Oils and Antimicrobial Activity
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- COVID-19 Pandemic Impacts
- Syphilis Diagnosis and Treatment
- COVID-19 and Mental Health
- Criminal Justice and Corrections Analysis
- HIV, Drug Use, Sexual Risk
- COVID-19 diagnosis using AI
Fundação Oswaldo Cruz
2016-2025
Universidade Federal de Mato Grosso do Sul
2018-2025
Yale University
2015-2025
Faculdades Oswaldo Cruz
2016-2024
Universidade Estadual de Mato Grosso do Sul
2023-2024
Universidade Federal de Mato Grosso
2020-2024
Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul
2015-2024
Stanford University
2015-2024
Fundação Carlos Chagas
2024
Faculty (United Kingdom)
2024
<h3>Importance</h3> There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the effect of chloroquine diphosphate (CQ) requires a high concentration drug. <h3>Objective</h3> To evaluate safety and efficacy 2 CQ dosages in patients with severe COVID-19. <h3>Design, Setting, Participants</h3> This parallel, double-masked, randomized, phase IIb clinical trial 81 adult who were hospitalized acute respiratory syndrome (SARS-CoV-2)...
To estimate the effectiveness of inactivated whole virus vaccine, CoronaVac (Sinovac Biotech), against symptomatic covid-19 in elderly population São Paulo state, Brazil during widespread circulation gamma variant.Test negative case-control study.Community testing for Brazil.43 774 adults aged ≥70 years who were residents state and underwent reverse transcription polymerase chain reaction (RT-PCR) SARS-CoV-2 from 17 January to 29 April 2021. 26 433 cases with 622 test controls symptoms...
The outbreak of new coronavirus disease 2019 (COVID-19) reported for the first time in Wuhan, China late December have rapidly spread to other countries and it was declared on January 30, 2020 as a public health emergency international concern (PHEIC) by World Health Organization. Before COVID-19 cases were Brazil, several measures been implemented including adjustment legal framework carry out isolation quarantine. As increased significantly, measures, mainly reduce mortality severe cases,...
The global outbreak caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been declared a pandemic World Health Organization. As number of imported SARS-CoV-2 cases is on rise in Brazil, we use incidence and historical air travel data to estimate most important routes importation into country.
Abstract The high numbers of COVID-19 cases and deaths in Brazil have made Latin America an epicentre the pandemic. SARS-CoV-2 established sustained transmission early pandemic, but important gaps remain our understanding virus dynamics at a national scale. We use 17,135 near-complete genomes sampled from 27 Brazilian states bordering country Paraguay. From March to November 2020, we detected co-circulation multiple viral lineages that were linked importations (predominantly Europe). After...
Abstract The effectiveness of inactivated vaccines (VE) against symptomatic and severe COVID-19 caused by omicron is unknown. We conducted a nationwide, test-negative, case-control study to estimate VE for homologous heterologous (BNT162b2) booster doses in adults who received two CoronaVac Brazil the Omicron context. Analyzing 1,386,544 matched-pairs, disease was 8.6% (95% CI, 5.6–11.5) 56.8% 56.3–57.3) period 8–59 days after receiving booster, respectively. During same interval, Covid-19...
The bacille Calmette-Guérin (BCG) vaccine has immunomodulatory "off-target" effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19).
The effectiveness of BCG vaccine for adult pulmonary tuberculosis remains uncertain. In this study, we aimed to evaluate the effect vaccination with BCG-Denmark prevent initial and sustained interferon-γ release assay conversion in Brazilian health-care workers.
Oropouche virus (OROV), first detected in Trinidad and Tobago 1955, was historically confined to the Brazilian Amazon Basin. However, since late 2022, an increasing number of OROV cases have been reported across various regions ofBrazilas well as urban centers Bolivia, Ecuador, Guyana, Colombia, Cuba, Panama Peru. In collaboration with Central Public Health Laboratories Brazil, we integrated epidemiological metadata genomic analyses from recent cases, generating 133 whole-genome sequences...
Summary Proteins with bacterial immunoglobulin‐like (Big) domains, such as the Yersinia pseudotuberculosis invasin and Escherichia coli intimin, are surface‐expressed proteins that mediate host mammalian cell invasion or attachment. Here, we report identification characterization of a new family Big domain proteins, referred to Lig (leptospiral Ig‐like) in pathogenic Leptospira . Screening L. interrogans kirschneri expression libraries sera from leptospirosis patients identified 13 lambda...
ABSTRACT Leptospirosis is an emerging zoonosis caused by pathogenic spirochetes belonging to the genus Leptospira . An understanding of leptospiral protein expression regulation needed develop new immunoprotective and serodiagnostic strategies. We used humoral immune response during human leptospirosis as a reporter antigens expressed infection. Qualitative quantitative immunoblot analysis was performed using sera from 105 patients Brazil Barbados. Sera with other diseases healthy...
Summary Background There is no specific antiviral therapy recommended for the disease caused by SARS-CoV-2 (COVID-19). Recent publications have drawn attention to possible benefit of chloroquine (CQ). Our study aimed comprehensively evaluate safety and efficacy two different CQ dosages in patients with established severe COVID-19. Methods We performed a parallel, double-blinded, randomized, phase IIb clinical trial, aiming assess as adjunctive hospitalized SARS Manaus, Brazilian Amazon....
<h3>Importance</h3> The World Health Organization identified the need for a non–sputum-based triage test to identify those in of further tuberculosis (TB) testing. <h3>Objective</h3> To determine whether 3-gene TB score can be diagnostic tool throughout course disease, from latency diagnosis treatment response, and posttreatment residual inflammation. <h3>Design, Setting, Participants</h3> This nested case-control study analyzed 3 cohorts, each focusing on different stage disease: (1)...
We conducted the genome sequencing and analysis of first confirmed COVID-19 infections in Brazil. Rapid coupled with phylogenetic analyses context travel history corroborate multiple independent importations from Italy local spread during initial stage transmission
We conducted a population-based study of tuberculosis (TB) cases in Dourados, Brazil, to assess the relationship between incarceration and TB general population. Incarceration was associated with an urban population; 54% Mycobacterium strains were related from persons prisons. control prisons is critical for reducing disease prevalence.
The new Coronavirus, called SARS-CoV-2, whose first cases emerged in Wuhan, China late December, 2019 and quickly spread to other countries, was declared on January 30, 2020 a public health emergency of international concern by the World Health Organization regional office for Europe. Even before COVID-19 were identified Brazil, country had articulated several measures ranging from creation ordinances laws, isolation quarantine. However, number has increased significantly, requiring...