Isadora Cristina de Siqueira
A5072143002- Mosquito-borne diseases and control
- Viral Infections and Vectors
- T-cell and Retrovirus Studies
- Global Maternal and Child Health
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Virology and Viral Diseases
- Vector-Borne Animal Diseases
- Trypanosoma species research and implications
- Malaria Research and Control
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Child Nutrition and Water Access
- Zoonotic diseases and public health
- Leptospirosis research and findings
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Maternal and Neonatal Healthcare
- Dengue and Mosquito Control Research
- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Long-Term Effects of COVID-19
- Cerebral Palsy and Movement Disorders
- Insect symbiosis and bacterial influences
- COVID-19 Clinical Research Studies
Fundação Oswaldo Cruz
2016-2025
Instituto Federal Goiano
2025
Ministério da Saúde
2003-2024
Universidade Federal da Bahia
2000-2016
Complexo Hospitalar Universitário Professor Edgard Santos
2009-2016
Yale University
2016
Hospital Ana Nery
2000-2009
Ministério da Saúde
2008
Escola Bahiana de Medicina e Saúde Pública
2003
Universidade de São Paulo
2002
Summary Proteins with bacterial immunoglobulin‐like (Big) domains, such as the Yersinia pseudotuberculosis invasin and Escherichia coli intimin, are surface‐expressed proteins that mediate host mammalian cell invasion or attachment. Here, we report identification characterization of a new family Big domain proteins, referred to Lig (leptospiral Ig‐like) in pathogenic Leptospira . Screening L. interrogans kirschneri expression libraries sera from leptospirosis patients identified 13 lambda...
Ideas and Opinions17 May 2016Emergence of Congenital Zika Syndrome: Viewpoint From the Front LinesFederico Costa, PhD, Manoel Sarno, MD, Ricardo Khouri, Bruno de Paula Freitas, Isadora Siqueira, Guilherme S. Ribeiro, Hugo C. Gubio Campos, Luiz Alcântara, Mitermayer G. Reis, Scott Weaver, Nikos Vasilakis, Albert I. Ko, Antonio Raimundo Almeida, PhDFederico PhDFrom Centro Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Sáude; Instituto Saúde Coletiva Faculdade Medicina Bahia,...
Zika virus (ZIKV) is an emerging flavivirus, which has caused a widespread outbreak in the Americas. Shortly after its introduction 2015, cluster of cases with Guillain–Barré syndrome was detected Brazil. Herein, we describe two from city Salvador, who developed ascending paresis acute exanthematous illness. The patients were admitted to intensive care unit tetraparesis and cranial nerve palsy, resolved intravenous administration human immunoglobulin. Serological evaluation IgM-specific ZIKV...
In recent years, an increasing number of outbreaks Dengue, Chikungunya and Zika viruses have been reported in Asia the Americas. Monitoring virus genotype diversity is crucial to understand emergence spread outbreaks, both aspects that are vital develop effective prevention treatment strategies. Hence, we developed efficient method classify sequences with respect their species sub-species (i.e. serotype and/or genotype). This tool provides easy-to-use software implementation this new was...
Neurodevelopment in 29 normocephalic children with utero exposure to Zika virus (ZIKV) was evaluated by the Bayley Scales of Infant and Toddler Development-Third Edition. Ten (35%) infants presented neurodevelopment delay. Language, cognitive motor delays were identified 9 (31%), 4 (14%) 1 (3%) infants, respectively. Children exposed ZIKV must undergo careful evaluations for early detection any order implement prompt intervention.
Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field classroom initiatives for the monitoring of DENV Brazil, generating 227 novel genome sequences DENV1-2 from 85 municipalities (2015-2019). This equated to an over 50% increase number genomes available databases. both phylogenetic epidemiological models retrospectively reconstructed recent...
Knowledge regarding the risks associated with Zika virus (ZIKV) infections in pregnancy has relied on individual studies relatively small sample sizes and variable risk estimates of adverse outcomes, or surveillance routinely collected data. Using data from Brazilian Cohorts Consortium, this study aims, to estimate outcomes among offspring women RT-PCR-confirmed ZIKV infection during explore heterogeneity between studies.We performed an participant meta-analysis 1548 pregnant 13 studies,...
Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined serum antibody response to ZIKV other flaviviruses in Brazilian women giving birth 2015–2016 outbreak. Infected pregnancies with intermediate or higher enhancement titers were at increased give microcephalic infants compared those lower (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant...
Background Visceral leishmaniasis (VL) is the most severe form of and potentially fatal if not diagnosed treated. Accurate timely diagnosis considered one pillars needed for reduction in disease-related lethality. Brazil currently three eco-epidemiological hotspots this disease. Several serological tests are commercially available country VL diagnosis, although information on performance these fragmented insufficient. The aim study was to directly compare six commercial kits: enzyme-linked...
Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition gangliosides and other components at nerve membranes. Using high-throughput ELISA, we have analyzed anti-glycolipid antibody profile, including gangliosides, plasma samples from patients infections or not GBS in Salvador, Brazil. We observed that develop present higher levels anti-ganglioside antibodies when compared to without GBS. also...
Abstract The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, dengue have had serious impacts on public health. Concerns been raised due to the rapid dissemination chikungunya virus across country since its first detection 2014 Northeast Brazil. In this work, we carried out on-site training activities genomic surveillance partnership with National Network Public Health Laboratories that led generation 422 genomes from 12 Brazilian states...
Background: The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated performance URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in Brazil. Methods: Residents from eight sites with different estimates provided one urine sample POC-ECO and stool Kato-Katz (KK) Helmintex® (HTX) testing as an egg-detecting reference infection...
Background Whilst vertical transmission of Zika virus (ZIKV) is established as the cause congenital syndrome (CZS), knowledge this emerging disease remains incomplete.
The use of non-invasive methods can contribute to the development predictive models for measuring carcass yield (CY) and hot weight (HCW) in domestic ruminants. In this study, vivo measurements subcutaneous fat thickness (SFT) ribeye area (REA) were performed on 111 Nellore heifers using ultrasound imaging. animals managed crop–livestock integrated systems with different supplementation levels (SL). Four multiple regression equations developed estimate CY HCW, five predictor variables: SFT,...
Background The Zika virus outbreak, which occurred from 2015 to 2016 in Brazil, resulted the birth of neonates with brain malformations arising Congenital Syndrome (CZS). characterization primitive reflexes and their relationships other motor characteristics, easily clinically detectable by health professionals, can aid establishing prognosis affected children. Objective To describe reflex patterns children Cerebral Palsy (CP) due CZS, investigate associations features. Method: Observational...
Abstract Background Chagas disease (CD) and visceral leishmaniasis (VL) are two important zoonotic diseases that present significant public health challenges in Latin America. Domestic dogs, due to their close contact with humans, serve as key reservoirs for both Trypanosoma cruzi (the causative agent of CD) Leishmania infantum VL), making them sentinels surveillance. This study, conducted part the Oxente Bahia Project, aimed assess seroprevalence anti- T. L. antibodies domestic dogs from...
Syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum, has high incidence rates among adults, pregnant women, and newborns. Diagnostic procedures typically involve treponemal test (such as ELISA, CMIA, IFI), followed non-treponemal (VDRL RPR). This study aimed to assess diagnostic performance of double antigen sandwich ELISA (DAgS-ELISA) using recombinant protein TpN17, analyzing serum samples from both infected not with T. pallidum. A total 712 were deemed...
Salvador (BA, Brazil) is an endemic area for human T-cell lymphotrophic virus type 1 (HTLV-1). The overall prevalence of HTLV-1 infection in the general population has been estimated to be 1.76%. carriers may develop a variety diseases such as adult leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with (IDH). IDH chronic severe form childhood exudative involving mainly scalp, neck ears. It recently observed that 30%...
The diagnosis of visceral leishmaniasis (VL) is still a major problem in Brazil and several other countries where the disease endemic. use an easy-to-use interpret, sensitive, specific method that requires no complex infrastructure or specialized professionals, such as direct agglutination test (DAT) rK39-based rapid immunochromatographic may enhance disease. This study evaluated performance (DiaMed- IT-LEISH®) DAT for VL 213 parasitologically confirmed cases 119 controls with clinical...
Summary Human T lymphotropic virus-type 1 (HTLV-1) is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult cell leukaemia/lymphoma and infective dermatitis associated with HTLV-1 (IDH). Over-production proinflammatory cytokines an increase in proviral load are features HAM/TSP, but immunological basis IDH has not been established. In addition to severe cutaneous manifestations, importance relies on observation that up 30% children develop HAM/TSP...
In 2015, during the outbreak of Zika virus (ZIKV) in Brazil, we identified 3 cases acute hearing loss after exanthematous illness. Serology yielded finding compatible with ZIKV as cause a confirmed (n = 1) and probable 2) flavivirus infection, indicating an association between infection transient loss.
Abstract Background Zika virus (ZIKV) is an emergent flavivirus initially considered a benign and self-limited exanthematic illness. In 2015, new epidemic emerged in northeastern of Brazil with increased incidence previously rare clinical outcome, microcephaly, newborns from mothers who were infected during pregnancy. Little known about the immunopathogenesis ZIKV-associated microcephaly. Understanding inflammatory profile degree inflammation persons affected such condition important step...