A5101452267- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Sphingolipid Metabolism and Signaling
- Galectins and Cancer Biology
- Calcium signaling and nucleotide metabolism
- Lysosomal Storage Disorders Research
- Autoimmune and Inflammatory Disorders Research
- Immune responses and vaccinations
- Parasite Biology and Host Interactions
- Immune cells in cancer
- Health, Nursing, Elderly Care
- Child Nutrition and Water Access
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Psoriasis: Treatment and Pathogenesis
University of Utah
2021
Washington University in St. Louis
2012-2014
Complexo Hospitalar Universitário Professor Edgard Santos
2006-2012
Universidade Federal da Bahia
2009-2012
Hospital Ana Nery
2009
Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis cutaneous produce higher levels of than do uninfected control subjects (P<.01). There was tendency for tissue to contain number cells expressing IL-17, compared leishmaniasis, there direct correlation between the presence cellular at lesion site (r2 = 0.86; P<.001) These data...
Accumulation of M2 macrophages in the liver, within context a strong Th2 response, is hallmark infection with parasitic helminth, Schistosoma mansoni, but origin these cells unclear. To explore this, we examined relatedness to monocytes this setting. Our data show that both monocyte-derived and resident are engaged response infection. Infection caused CCR2-dependent increases numbers Ly6Chi blood liver CX3CR1+ diseased liver. recovered from had potential differentiate into when cultured...
Salvador (BA, Brazil) is an endemic area for human T-cell lymphotrophic virus type 1 (HTLV-1). The overall prevalence of HTLV-1 infection in the general population has been estimated to be 1.76%. carriers may develop a variety diseases such as adult leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with (IDH). IDH chronic severe form childhood exudative involving mainly scalp, neck ears. It recently observed that 30%...
Summary Human T lymphotropic virus-type 1 (HTLV-1) is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult cell leukaemia/lymphoma and infective dermatitis associated with HTLV-1 (IDH). Over-production proinflammatory cytokines an increase in proviral load are features HAM/TSP, but immunological basis IDH has not been established. In addition to severe cutaneous manifestations, importance relies on observation that up 30% children develop HAM/TSP...
Abstract The majority of patients infected with human T‐cell lymphotropic virus‐type 1 (HTLV‐1) are considered carriers, but a high frequency urinary symptoms overactive bladder, common in HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) have been documented these patients. aim this study was to determine if immunological and viral factors that seen HAM/TSP also observed Participants were classified as carriers (n = 45), suffering from bladder 45) 45). Cells produced...
Human T lymphotropic virus-type 1 (HTLV-1) activates the immune system leading to a persistent and exacerbated T-cell response with increased production of IFN-gamma TNF-alpha. Overproduction pro-inflammatory cytokines is correlated development HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although some HTLV-1 carriers also show high levels these cytokines. In this study, ability regulatory cytokine antagonists inhibit spontaneous was investigated.IFN-gamma were...
Macrophages have a defined role in the pathogenesis of metabolic disease and cholesterol metabolism where alternative activation macrophages is thought to be beneficial both glucose during high fat diet induced disease. It well established that helminth infection protects from disease, but mechanisms underlying protection are not understood. Here, we investigated effects Schistosoma mansoni cytokine signatures bone marrow derived using an approach integrated transcriptomics, metabolomics,...
Salvador (BA, Brazil) is an endemic area for human T-cell lymphotrophic virus type 1 (HTLV-1). The overall prevalence of HTLV-1 infection in the general population has been estimated to be 1.76%. carriers may develop a variety diseases such as adult leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with (IDH). IDH chronic severe form childhood exudative involving mainly scalp, neck ears. It recently observed that 30%...
Results We demonstrated that cells from HTLV-1 overactive bladder produce higher spontaneous levels of IFN-g, TNF-a and IL-17 than carriers similar to HAM/TSP. Proviral load was in HAM/TSP correlated positively with production proinflammatory cytokines. In contrast HAM/TSP, had serum Th1 chemokines exogenous addition regulatory cytokines (IL-10 TGF-b) decreased IFN-g cell cultures bladder. Conclusions conclude patients have some immunological features proviral profiles common However as they...