A5086311928- Immune Cell Function and Interaction
- Immune cells in cancer
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- CAR-T cell therapy research
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Tuberculosis Research and Epidemiology
- interferon and immune responses
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Gene expression and cancer classification
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Gene Regulatory Network Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
Washington University in St. Louis
2016-2025
ITMO University
2016-2023
German Center for Neurodegenerative Diseases
2020-2021
University School
2021
Broad Institute
2010-2017
Immuneering (United States)
2014-2015
Massachusetts Institute of Technology
2007-2011
Howard Hughes Medical Institute
2011
Ragon Institute of MGH, MIT and Harvard
2011
IIT@MIT
2010
Abstract Gene set enrichment analysis (GSEA) is an ubiquitously used tool for evaluating pathway in transcriptional data. Typical experimental design consists comparing two conditions with several replicates using a differential gene expression test followed by preranked GSEA performed against collection of hundreds and thousands pathways. However, the reference implementation this method cannot accurately estimate small P-values, which significantly limits its sensitivity due to multiple...
Recent advancements have brought to light the origins, complexity, and functions of tissue-resident macrophages. However, in context tissue injury or disease, large numbers monocytes infiltrate heart are thought contribute adverse remodeling failure pathogenesis. Little is understood about diversity monocyte-derived macrophages recruited after myocardial injury, including mechanisms that regulate monocyte recruitment fate specification.We sought test hypothesis distinct subsets CCR2- (C-C...
Natural killer (NK) cells belong to the innate immune system; they can control virus infections and developing tumors by cytotoxicity producing inflammatory cytokines. Most studies of mouse NK cells, however, have focused on conventional (cNK) in spleen. Recently, we described two populations liver tissue-resident (trNK) those resembling splenic cNK cells. However, their lineage relationship was unclear; trNK could be related thymic or a distinct from both Herein used detailed...
The microbiota is known to modulate the host response influenza infection through as-yet-unclear mechanisms. We hypothesized that components of exert effects type I interferon (IFN), a hypothesis supported by analysis in gain-of-function genetic mouse model. Here we show microbially associated metabolite, desaminotyrosine (DAT), protects from augmentation IFN signaling and diminution lung immunopathology. A specific human-associated gut microbe, Clostridium orbiscindens, produced DAT rescued...
Turning viral persistence on and off Norovirus causes >90% of the world's gastroenteritis. can establish persistent infections, which may contribute to its spread. How does norovirus itself as a permanentw resident gut how such infections be cured (see Perspective by Wilks Golovkina)? Baldridge et al. studied mice persistently infected with found that required microbiota: bacteria in gastrointestinal tract. Antibiotics prevented mouse infection way depended secreted antiviral protein...
Rationale: Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are most prominent features of atherosclerosis. To understand pathophysiology atherosclerotic disease, we need to characteristics lipid-laden foamy macrophages in during Objective: We sought examine transcriptomic profiles nonfoamy isolated from intima. Methods Results: Single-cell RNA sequencing analysis CD45 + leukocytes murine aorta revealed that there macrophage subpopulations with...