A5010607078- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Erythrocyte Function and Pathophysiology
- Immune cells in cancer
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Phagocytosis and Immune Regulation
- Dietary Effects on Health
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Immune Response and Inflammation
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Blood disorders and treatments
- Obesity and Health Practices
- IL-33, ST2, and ILC Pathways
- Acute Myeloid Leukemia Research
- Gut microbiota and health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Iron Metabolism and Disorders
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
Soochow University
2017-2025
Shanghai Jiao Tong University
2023-2024
Pennington Biomedical Research Center
2021-2024
Albert Einstein College of Medicine
2014-2024
University of Toronto
2024
Louisiana State University
2024
The First People's Hospital of Changzhou
2017-2024
St. Michael's Hospital
2024
Louisiana State University System
2022-2023
Tsinghua University
2018-2023
Time restricted eating (TRE) is an emerging dietary intervention for weight loss that hypothesized to reinforce the metabolic benefits of nightly fasting/ketosis. This pilot study investigated effectiveness a daily 14-h fast (14:10 TRE beginning after dinner, "fasting snack" at hour 12, and ending with breakfast 14 h later) combined commercial management program on body fasting blood glucose (FBG) in individuals obesity. We also effect low-calorie, high-fat, low-carbohydrate, low-protein...
Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential associated to dormancy. Here we identify the cell surface receptor neogenin-1 as specifically expressed in dormant HSCs. Loss of initially leads increased HSC expansion but subsequently loss and premature exhaustion vivo. Its ligand netrin-1 induces Egr1 expression maintains quiescence function cultured HSCs a Neo1 dependent manner. Produced arteriolar endothelial periarteriolar stromal cells, conditional...
High-throughput sequencing has ushered in a paradigm shift gastric microbiota, breaking the stereotype that stomach is hostile to microorganisms beyond H. pylori. Recent attention directed toward composition and functionality of this 'community' shed light on its potential relevance cancer. The microbial health displays host specificity which changes throughout person's lifespan subject both external internal factors. Distinctive alterations microbiome signature are discernible at different...
In patients with gastric cancer, the prognostic value of tumor-infiltrating lymphocytes (TILs) is still controversial. A meta-analysis was performed to evaluate TILs in cancer.We identify studies from PubMed, Embase and Cochrane Library assess effect cancer. Fixed-effects models or random-effects were used estimate pooled hazard ratios (HRs) for overall survival (OS) disease-free (DFS), which depend on heterogeneity.A total 31 observational including 4,185 enrolled. For subsets, amount CD8+,...
Abstract Autophagosomes are double-membrane vesicles generated intracellularly to encapsulate substrates for lysosomal degradation during autophagy. Phase separated p62 body plays pivotal roles autophagosome formation, however, the underlying mechanisms still not fully understood. Here we describe a spatial membrane gathering mode by which functions in formation. Mass spectrometry-based proteomics reveals significant enrichment of vesicle trafficking components within body. Combining...
Abstract Cells mitigate ER stress through the unfolded protein response (UPR). Here, we report formation of whorls as an effector mechanism response. We found that strong induces whorls, which contain ER-resident proteins such Sec61 complex and PKR-like kinase (PERK). whorl is dependent on PERK activity mediated by COPII machinery, facilitates membrane budding to form tubular-vesicular precursors. precursors then go Sec22b-mediated fusion whorls. further show contribute stress-induced...
The incidence of acute cardiovascular complications is highly time-of-day dependent. However, the mechanisms driving rhythmicity ischemic vascular events are unknown. Although enhanced numbers leukocytes have been linked to an increased risk complications, role that rhythmic leukocyte adhesion plays in different beds has not studied. We evaluated recruitment vivo by using real-time multichannel fluorescence intravital microscopy a tumor necrosis factor-α-induced inflammation model both...
Abstract Immune checkpoint blockade (ICB) immunotherapy has revolutionized cancer treatment by prolonging overall survival of patients with cancer. Despite advances in the clinical setting, immune cellular network tumor microenvironment (TME) that mediates such therapy is not well understood. IL33 highly expressed normal epithelial cells but downregulated advanced carcinoma. Here, we showed was induced after ICB as CTL antigen-4 (CTLA-4) and programmed death-1 (PD-1) mAbs. ST2 signaling...