A5082163849- Axon Guidance and Neuronal Signaling
- Hedgehog Signaling Pathway Studies
- Angiogenesis and VEGF in Cancer
- Developmental Biology and Gene Regulation
- Neurogenesis and neuroplasticity mechanisms
- Kruppel-like factors research
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- Advanced Neuroimaging Techniques and Applications
- Cancer Cells and Metastasis
- Advanced X-ray Imaging Techniques
- Epigenetics and DNA Methylation
- Photosynthetic Processes and Mechanisms
- Apelin-related biomedical research
- CRISPR and Genetic Engineering
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Plant Genetic and Mutation Studies
- Lung Cancer Research Studies
- Silkworms and Sericulture Research
- Pancreatic and Hepatic Oncology Research
- Peanut Plant Research Studies
- Reproductive Biology and Fertility
- Plant Stress Responses and Tolerance
Université Claude Bernard Lyon 1
2016-2025
Centre National de la Recherche Scientifique
2014-2025
Centre Léon Bérard
2014-2025
Inserm
2016-2025
Centre de Recherche en Cancérologie de Lyon
2016-2025
Lyon College
2021-2023
Cancer Research Center
2023
Centro de Investigación del Cáncer
2023
Centre International de Recherche en Infectiologie
2023
University of Agricultural Sciences, Bangalore
2010-2016
Abstract Netrin-1 is upregulated in cancers as a protumoural mechanism 1 . Here we describe netrin-1 upregulation majority of human endometrial carcinomas (ECs) and demonstrate that blockade, using an anti-netrin-1 antibody (NP137), effective reduction tumour progression EC mouse model. We next examined the efficacy NP137, first-in-class single agent, Phase I trial comprising 14 patients with advanced EC. As best response observed 8 stable disease (8 out 14, 57.1%) objective RECIST v.1.1...
Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues either during nervous system development or the establishment vascular system. This was clearly demonstrated for netrin-1 via its interaction with receptors DCC and UNC5s. However, mainly based on shared homologies netrin-1, netrin-4 also play role in neuronal outgrowth developmental/pathological angiogenesis interactions receptors. Here, we present high-resolution structure netrin-4, which shows...
Netrin-1 is upregulated in a large fraction of human neoplasms. In multiple animal models, interference with netrin-1 associated inhibition tumor growth and metastasis. Although upregulation was initially described cancer cells, we report here that the colorectal database, expression its receptor UNC5B correlates cancer-associated fibroblasts (CAF) signature. Both colon lung CAF secreted when cocultured respective increased cell stemness. Pharmacologic netrin-1-mAb (Net1-mAb) abrogated...
Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential associated to dormancy. Here we identify the cell surface receptor neogenin-1 as specifically expressed in dormant HSCs. Loss of initially leads increased HSC expansion but subsequently loss and premature exhaustion vivo. Its ligand netrin-1 induces Egr1 expression maintains quiescence function cultured HSCs a Neo1 dependent manner. Produced arteriolar endothelial periarteriolar stromal cells, conditional...
CDON is a novel Sonic Hedgehog (SHH) dependence receptor and targeting the SHH-CDON interaction could represent an alternative therapeutic strategy for patients suffering from tumors that express high SHH levels.
Abstract Coordinated changes of cellular plasticity and identity are critical for pluripotent reprogramming oncogenic transformation. However, the sequences events that orchestrate these intermingled modifications have never been comparatively dissected. Here, we deconvolute trajectories (via Oct4/Sox2/Klf4/c-Myc) transformation Ras/c-Myc) at single-cell resolution reveal how two processes intersect before they bifurcate. This approach led us to identify transcription factor Bcl11b as a...
Abstract Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread metastatic cancers. Most current approaches rely on use vectors to deliver radionuclides tumor cells, targeting membrane‐bound cancer‐specific moieties. Here, we report embryonic navigation cue netrin‐1 as an unanticipated target vectorized radiotherapy. While netrin‐1, known be re‐expressed in tumoral cells promote cancer progression, usually characterized diffusible ligand, demonstrate here...
DCC (Deleted in Colorectal Cancer) is a putative tumor suppressor whose expression lost numerous cancers and activity appears to be dependent on its ability trigger apoptosis when disengaged by ligand netrin-1. In this sense, netrin-1 survival factor that controls tumorigenesis. However, also the prototypical axon guidance cue has been shown orient many neurons or axons, especially commissural during spinal cord development. Here we show not only an attractive for developing axons but...
The navigation cue netrin-1 is well-documented for its key role in cancer development and represents a promising therapeutic target currently under clinical investigation. Phase 1 2 trials are ongoing with NP137, humanized monoclonal antibody against netrin-1. Interestingly, the epitope recognized by NP137 shares 90% homology counterpart netrin-3, closest member to humans, which little known field of cancer. Here, we unveiled that netrin-3 appears be expressed specifically human...
The molecular code that controls synapse formation and maintenance in vivo has remained quite sparse. Here, we identify the secreted protein Adamtsl3 functions as critical hippocampal organizer acting through transmembrane receptor DCC (deleted colorectal cancer). Traditionally, function been associated with glutamatergic synaptogenesis plasticity response to Netrin-1 signaling. We demonstrate early post-natal deletion of neurons impairs expression, causing reduced density both GABAergic...
Abstract Notch signalling is a causal determinant of cancer and efforts have been made to develop targeted therapies inhibit the so-called canonical pathway. Here we describe an unexpected pro-apoptotic role Notch3 in regulating tumour angiogenesis independently The ligand Jagged-1 upregulated fraction human our data support view that Jagged-1, produced by cells, inhibiting apoptosis induced aberrant expression vasculature. We thus present as dependence receptor inducing endothelial cell...
Nutrient availability is a key determinant of tumor cell behavior. While nutrient-rich conditions favor proliferation and growth, scarcity, particularly glutamine starvation, promotes dedifferentiation chemoresistance. Here, linking ribosome biogenesis plasticity with fate, we uncover that the amino acid sensor general control non-derepressible 2 (GCN2; also known as eIF-2-alpha kinase 4) represses expression precursor ribosomal RNA (rRNA), 47S, under metabolic stress. We show blockade GCN2...
Small intestinal neuroendocrine tumors (siNETs) are rare bowel arising from malignant enteroendocrine cells, which normally regulate digestion throughout the intestine. Though infrequent, their incidence is rising through better diagnosis, fostering research into origin and treatment. To date, siNETs considered to be a single entity clinically treated as such. Here, by performing multi-omics analysis of siNETs, we unveil four distinct molecular groups with strong clinical relevance provide...