A5101989331- Cardiovascular and exercise physiology
- Sports Performance and Training
- Muscle activation and electromyography studies
- Lymphoma Diagnosis and Treatment
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Economic and Financial Impacts of Cancer
- Heart Rate Variability and Autonomic Control
- Primary Care and Health Outcomes
- Transcranial Magnetic Stimulation Studies
- Hormonal and reproductive studies
- Clinical practice guidelines implementation
- Geriatric Care and Nursing Homes
- Frailty in Older Adults
- Medical Education and Admissions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lipid metabolism and disorders
- Immunotherapy and Immune Responses
- Communication in Education and Healthcare
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Reproductive Health and Contraception
- Gastroesophageal reflux and treatments
- Cystic Fibrosis Research Advances
- Platelet Disorders and Treatments
University of Calgary
2007-2025
Natural Sciences and Engineering Research Council
2025
Agilent Technologies (United States)
2024
California State University, Fullerton
2018-2023
Jiangsu University
2023
Decision Sciences (United States)
2023
Seagen (United States)
2022
The US Oncology Network
2022
Arizona Oncology
2022
Immuneering (United States)
2018-2022
To describe the data and analyses that led to U.S. Food Drug Administration (FDA) approval of ofatumumab (Arzerra, GlaxoSmithKline) for treatment patients with chronic lymphocytic leukemia (CLL) refractory fludarabine alemtuzumab.The FDA reviewed results a planned interim analysis single-arm trial, enrolling 154 CLL fludarabine, supportive dose-finding, activity-estimating trial in 33 CLL. Patients primary efficacy study received weekly eight doses, then every 4 weeks an additional four...
Background: Nucleoside and ritonavir (RTV) toxicities have led to increased interest in nucleoside reverse transcriptase inhibitors (NRTIs) RTV-sparing antiretroviral regimens. SPARTAN was a multicenter, randomized, open-label, noncomparative pilot study evaluating the efficacy, safety, resistance profile of an investigational NRTI- regimen (experimental atazanavir [ATV] dose 300 mg bid + raltegravir [RAL] 400 [ATV+RAL]). The reference consisted ATV mg/RTV 100 qd tenofovir (TDF)...
A comprehensive characterization of neuromuscular and perceptual mechanisms fatigue at task failure following exercise across the entire intensity spectrum is lacking. This study evaluated extent peripheral central fatigue, corresponding attributes, cycling within moderate-(MOD), heavy-(HVY), severe-(SVR), extreme-(EXT) domains. After a ramp-incremental test, 11 young males performed four constant-power output trials to limit tolerance (Tlim) 4 distinct domain-specific workloads. These were...
Near-infrared spectroscopy (NIRS) provides a simple and reliable measure of skeletal muscle oxidative capacity; however, its relationship to aerobic fitness sex are unclear. We hypothesized that NIRS-derived capacity in the vastus lateralis (VL) medial gastrocnemius (MG) would be correlated with indices independent sex. Twenty-six participants (13 males, 13 females) performed ramp- step-incremental tests volitional exhaustion on separate days establish maximal oxygen uptake (V̇o2max), peak...
Student engagement in online learning remains a challenge for the design of effective coursework. Additionally, few analyses have focused on student-produced activities mode nor upon how such class activity affect student sub-groups differently. We conducted randomized experiment with video production at large public university. background and behavior factors were measured two surveys, which combined course assessment data. Because small sample size, we observe significant differences...
Abstract Background and Objectives Older adults with multiple comorbidities experience high rates of hospitalization poor outcomes from Coronavirus Disease 2019 (COVID-19). Changes in care utilization by persons advanced illness management (AIM) programs during the COVID-19 pandemic are not well known. The purpose this study was to describe changes homebound AIM patients an epicenter before pandemic. Research Design Methods Descriptive statistics tests differences were used compare rates,...
Background Coadministration of oral contraceptives with protease inhibitors is complicated by drug interactions. An open-label three-period single-sequence study assessed the effect coadministration atazanavir (ATV)/ritonavir (RTV) Ortho Tri-Cyclen® and Tri- Cyclen® LO (Ortho-McNeil-Janssen Pharmaceuticals, Inc., Raritan, NJ, USA) on pharmacokinetics (PK) ethinyl estradiol (EE), norgestimate (NGM), ATV RTV. Methods A total 20 healthy women aged 18–45 years received treatments. In lead-in...
Study Objective To investigate the pharmacokinetic and pharmacodynamic relationships of human immunodeficiency virus (HIV) –protease inhibitor atazanavir ( ATV ) in presence absence booster ritonavir, utilizing plasma trough concentrations (C clinical biomarkers antiviral efficacy safety over 48 weeks. Design Randomized, open‐label, multicenter, study designed to compare 300 mg plus ritonavir 100 300/r) with that 400 400). Setting Thirty clinic sites across 10 countries Africa, Europe, North...
Mitochondrial dysfunction plays a significant role in neurodegenerative disease including ataxias and other movement disorders, particularly those marked by progressive degeneration the cerebellum. In this study, we investigate of mitochondrial oxidative phosphorylation (OXPHOS) deficits cerebellar tissue Purkinje cell-driven spinocerebellar ataxia type 1 (SCA1) mouse. Using RNA sequencing transcriptomics, OXPHOS complex assembly analysis oxygen consumption assays, report that presence...
Neuromuscular (NM), cardiorespiratory, and perceptual responses to maximal-graded exercise using different amounts of active muscle mass remain unclear. We hypothesized that during dynamic exercise, peripheral NM fatigue (declined twitch force) pain would be greater smaller mass, whereas central voluntary activation) ventilatory variables larger mass. Twelve males (29.8 ± 4.7 years) performed two ramp-incremental cycling tests until task failure: 1) single-leg (SL) with 10 W·min −1 ramp 2)...
ABSTRACT Introduction In numerous sport and occupational settings, individuals often need to perform multiple exercise sessions in one day or across consecutive days, yet performance perceptual responses such paradigms are unclear. PURPOSE: This study investigated fatigue repeated, of high-intensity interval (HIIT) constant-work rate (CWR) cycling bouts performed within 24 hours. Methods Seventeen healthy adults (nine females, aged 25 ± 6 years) exercised the morning, same afternoon,...
Atazanavir plus raltegravir 300/400 mg twice daily is being explored as a ritonavir- and nucleoside-sparing treatment strategy. The pharmacokinetics safety of this combination in healthy individuals were evaluated.A total 22 received 400 on days 1-5, atazanavir 300 6-12 13-26, with light meal. Serial blood samples collected 12 h after the morning dose 5, 26; assessments, clinical laboratory data serial electrocardiograms (ECGs) at 0, 2 6 obtained.Raltegravir coadministration reduced...
Abstract Absent T lymphocytes were unexpectedly found in homozygotes of a transgenic mouse from an unrelated project. cell development did not progress beyond double-negative stage 1 thymocytes, resulting hypocellular, vestigial thymus. B cells present, but NK number and isotype switching reduced. Transplantation wild-type hematopoietic corrected the defect, which was traced to deletion involving five contiguous genes at transgene insertion site on chromosome 12C3. Complementation using...
Classical training theory postulates that performance fatigability following a session should be proportional to the total work done (TWD); however, this notion has been questioned. This study investigated indices of and perceived after primary sessions high-intensity interval (HIIT) constant rate (CWR) cycling, each followed by cycling time-to-task failure (TTF) bout. On separate days, 16 participants completed an incremental test, and, in randomized order, (i) TTF trial at 80% peak power...