A5081828105- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Angiogenesis and VEGF in Cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Nuclear Receptors and Signaling
- Atherosclerosis and Cardiovascular Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Cell Adhesion Molecules Research
- Kruppel-like factors research
- Chromatin Remodeling and Cancer
- Polyamine Metabolism and Applications
- Glutathione Transferases and Polymorphisms
- Nitric Oxide and Endothelin Effects
- Mesenchymal stem cell research
- Caveolin-1 and cellular processes
- Acute Kidney Injury Research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- Protein Kinase Regulation and GTPase Signaling
Centre Léon Bérard
2014-2024
Inserm
2001-2023
Université Claude Bernard Lyon 1
2023
Centre de Recherche en Cancérologie de Lyon
2014-2023
Centre National de la Recherche Scientifique
2023
NIHR Bristol Cardiovascular Biomedical Research Unit
2007
University of Rochester
2005-2007
University of Bristol
2007
Thrombosis Research Institute
2005-2006
University of Rochester Medical Center
2005
Abstract Netrin-1 is upregulated in cancers as a protumoural mechanism 1 . Here we describe netrin-1 upregulation majority of human endometrial carcinomas (ECs) and demonstrate that blockade, using an anti-netrin-1 antibody (NP137), effective reduction tumour progression EC mouse model. We next examined the efficacy NP137, first-in-class single agent, Phase I trial comprising 14 patients with advanced EC. As best response observed 8 stable disease (8 out 14, 57.1%) objective RECIST v.1.1...
Vismodegib specifically inhibits Sonic Hedgehog (SHH). We report results of a phase I/II evaluating vismodegib + temozolomide (TMZ) in immunohistochemically defined SHH recurrent/refractory adult medulloblastoma.
Big MAP kinase 1 (BMK1 or ERK5) is a key mediator of endothelial cell (EC) function as shown by impaired embryonic angiogenesis and vascular collapse in BMK1 knockout mice. Hypoxia inducible factor 1alpha (HIF1alpha), potent angiogenesis, positively regulated the kinases, ERK1/2. Because deficiency associated with we hypothesized that might regulate HIF1alpha. To test this hypothesis, bovine lung microvascular ECs (BLMECs) were transfected HIF1alpha cDNAs, stimulated hypoxia. activity was...
Unidirectional laminar flow is atheroprotective, in part by inhibiting cytokine-mediated endothelial cell (EC) inflammation and apoptosis. Previously, we showed that inhibited TNF-alpha signaling preventing activation of JNK. Recently, PKCzeta was identified as the PKC isoform most strongly regulated pattern, with increased activity regions disturbed versus unidirectional flow. Interestingly, cleaved caspases after stimulation to generate a 50-kDa truncated form (CATzeta, catalytic domain...
Xevinapant is an orally available inhibitor of apoptosis proteins (IAP) inhibitor. Preclinical data suggest that IAP antagonism may synergize with immune checkpoint blockers by modulating the NFκB pathway in cells.
NK cells are cytotoxic lymphocytes displaying strong antimetastatic activity. Mouse models and in vitro studies suggest a prominent role of the mechanistic target rapamycin (mTOR) kinase control cell homeostasis antitumor functions. However, mTOR inhibitors used as chemotherapies several cancer settings. The impact such treatments on patients' is unknown. We thus performed immunophenotyping circulating from metastatic breast patients treated with inhibitor everolimus over three-month period....
Purpose: Metastatic endocrine-resistant breast cancer (MBC) is a disease with poor prognosis and few treatment options. Low lymphocyte count associated limited overall survival. In prospective cohort of lymphopenic patients HER-2 negative MBC, we assessed the clinical biological impact pembrolizumab combined metronomic cyclophosphamide. Experimental Design: This multicenter Phase II study evaluated safety activity (intravenous (IV), 200mg, every 3 weeks) cyclophosphamide (50mg/day, per os)...
<p>Supplemetary figures S1, S2 and S3</p>
<p>Supplemetary figures S1, S2 and S3</p>
<p>Representativeness</p>
<div>AbstractPurpose:<p>Xevinapant is an orally available inhibitor of apoptosis proteins (IAP) inhibitor. Preclinical data suggest that IAP antagonism may synergize with immune checkpoint blockers by modulating the NFκB pathway in cells.</p>Patients and Methods:<p>Adult patients non–high microsatellite instability advanced/metastatic pancreatic ductal adenocarcinoma (PDAC) or colorectal cancer were enrolled this phase Ib/II study received pembrolizumab 200 mg every 3...
<p>Representativeness</p>
<div>AbstractPurpose:<p>Xevinapant is an orally available inhibitor of apoptosis proteins (IAP) inhibitor. Preclinical data suggest that IAP antagonism may synergize with immune checkpoint blockers by modulating the NFκB pathway in cells.</p>Patients and Methods:<p>Adult patients non–high microsatellite instability advanced/metastatic pancreatic ductal adenocarcinoma (PDAC) or colorectal cancer were enrolled this phase Ib/II study received pembrolizumab 200 mg every 3...
Arterial smooth muscle cells (SMCs) play a major role in atherosclerosis and restenosis. Differential display was used to compare transcription profiles of synthetic SMCs proliferating rat cultured SMC line. An isolated cDNA band (6A3-5) shown by northern (7 kb) be upregulated the cell A tissue showed differential expression this gene different tissues. Using 5' RACE screening brain library, part cloned sequenced (5.4 kb). Sequence searches important similarities with new family factors,...
Abstract Background: Total and CD4 lymphopenia is observed in 25% of advanced cancers patients a predictive factor chemotherapy (CT)-induced death, febrile neutropenia, thrombocytopenia, anemia, as well an independent prognostic for survival tumor progression. CYT107 glycosylated recombinant human IL-7 (CYTHERIS, France) emerging promising immuno-restorative agent tolerated Phase 1 trials. To date, it unknown whether can correct during CT this could translate into clinical benefit cancer...
Abstract Surgery is still a essential step for breast cancer treatment. Complete tumor removal during surgery rely on surgeon's ability to differentiate from normal tissue. To date, no intra operative method available and reliable enough help the surgeon delineate precisely extension in adjacent Thus, surgeons solely pre imaging techniques margins. Recent advances made field of non-invasive vectorized nano-size particles have revealed remarkable potential improved tumor-margin detection....