A5035757408- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- PARP inhibition in cancer therapy
- Sarcoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- CRISPR and Genetic Engineering
- Pelvic floor disorders treatments
- Colorectal Cancer Surgical Treatments
- Intraperitoneal and Appendiceal Malignancies
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Testicular diseases and treatments
- Molecular Biology Techniques and Applications
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Pelvic and Acetabular Injuries
- Gynecological conditions and treatments
- DNA Repair Mechanisms
- Lung Cancer Research Studies
- Cancer Risks and Factors
- Breast Implant and Reconstruction
Centre Léon Bérard
2015-2025
Université Claude Bernard Lyon 1
2025
Centre de Recherche en Cancérologie de Lyon
2015-2025
University of Genoa
2017-2020
Ospedale Policlinico San Martino
2017-2020
Institut Paoli-Calmettes
2020
Hôpital Femme Mère Enfant
2015
Purpose: BRCA2 plays a central role in homologous recombination by loading RAD51 on DNA breaks. The objective of this study is to determine whether the location mutations RAD51-binding domain (RAD51-BD; exon 11) gene affects clinical outcome ovarian cancer patients.Experimental Design: A cohort 353 women with who underwent genetic germline testing for BRCA1 and genes was identified. Progression-free survival (PFS), platinum-free interval (PFI), overall (OS) were analyzed. Cancer Genome Atlas...
SLFN11 is a recently discovered protein with putative DNA/RNA helicase function. First identified in association the maturation of thymocytes, was later causally associated, by two independent groups, resistance to DNA damaging agents such as topoisomerase I and II inhibitors, platinum compounds, other alkylators, making it an attractive molecule for biomarker development. Later, linked antiviral response human cells interferon production, establishing potential bond between immunity...
Large independent analyses on cancer cell lines followed by functional studies have identified Schlafen 11 (SLFN11), a putative helicase, as the strongest predictor of sensitivity to DNA-damaging agents (DDAs), including platinum. However, its role prognostic biomarker is undefined, partially due lack validated methods score SLFN11 in human tissues. Here, we implemented pipeline quantify samples. By analyzing cohort high-grade serous ovarian carcinoma (HGSOC) specimens before platinum-based...
Primary ovarian leiomyosarcomas are exceptionally rare, constituting less than 1% of tumors, and they typically have a poor prognosis. The available data on the management these tumors sparse, with limited publications mainly comprising small retrospective series that include multiple histologic types. aim is to evaluate clinical, surgical, pathologic characteristics clinical outcome patient affected by primary leiomyosarcomas. Using national database (NetSarc), we conducted study outcomes...
Abstract Background The term uterine smooth muscle tumor of uncertain malignant potential (STUMP) indicates a rare, equivocal entity between benign leiomyomas and leiomyosarcomas. In the present study, we evaluated comprehensive range clinical, surgical, pathological features in large multicenter series patients with STUMP to identify risk factors for recurrence. Methods This is retrospective study performed by collecting consecutive cases diagnosed January 2000 December 2020 five tertiary...
The status of regional node remains one the most important factors to guide adjuvant therapy in endometrial cancer (EC). Pelvic recurrence occurs up 15% early EC patients with negative pelvic lymph nodes (LNs). prognostic significance detecting micrometastases (μM) LN is debated. This retrospective case-control study performed Oncological Gynecology Department Lyon between December 1998 and June 2012 reports incidence clinical μM detected during ultrastaging sentinel (SLN) EC.Ninety-three...
Immunohistochemistry (IHC) and fluorescent-in situ hybridization (FISH) are standard methods to assess human epidermal growth factor receptor 2 (HER2) status in breast cancer (BC) patients. Real-time quantitative polymerase-chain-reaction (qRT-PCR) is able detect HER2 overexpression. Here we compared FISH, IHC, PCR (qPCR), qRT-PCR determine the concordance rates evaluate their relative roles determination. We determined 153 BC patients, using Q-PCR qRT-PCR. In discordant cases, directly...
Abstract The classical surgical anatomy of the female pelvis is limited by its gynecological oncological focus on parametrium and burdened modeling based personal techniques different surgeons. However, treatment pelvic diseases, spreading beyond anatomical area origin, requires extra-regional procedures a thorough knowledge. This study evaluated feasibility comprehensive simplified model retroperitoneal compartmentalization, rather than structures. Such aims at providing an easier, holistic...
Low-grade uterine endometrial stromal sarcoma (LG-ESS) is a rare tumor characterized by an overall good survival but showing indolent behavior and variable risk of recurrence. There no clear consensus on the optimal management these tumors prognostic or predictive factors have been established. With this study, we evaluated relevance several clinical, surgical, pathological features in patients affected LG-ESS to identify associated with recurrence.We retrospectively analyzed 52 cases,...