A5081577791- Acute Myeloid Leukemia Research
- Cancer Cells and Metastasis
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Chronic Myeloid Leukemia Treatments
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Immune cells in cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Melanoma and MAPK Pathways
- Cancer, Hypoxia, and Metabolism
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
Heidelberg University
2016-2025
Heidelberg Institute for Stem Cell Technology and Experimental Medicine
2016-2025
German Cancer Research Center
2016-2025
Deutschen Konsortium für Translationale Krebsforschung
2016-2025
DKFZ-ZMBH Alliance
2016-2025
National Center for Tumor Diseases
2012-2023
Heidelberg University
2023
TRUMPF (Germany)
2023
German Cancer Society
2022
Cancer Research Center
2018-2021
The activity of adult stem cells is essential to replenish mature constantly lost due normal tissue turnover. By a poorly understood mechanism, are maintained through self-renewal while concomitantly producing differentiated progeny. Here, we provide genetic evidence for an unexpected function the c-Myc protein in homeostasis hematopoietic (HSCs). Conditional elimination bone marrow (BM) results severe cytopenia and accumulation HSCs situ. Mutant self-renew accumulate their failure initiate...
The mechanisms controlling neural stem cell proliferation are poorly understood. Here we demonstrate that the PTEN tumor suppressor plays an important role in regulating stem/progenitor cells vivo and vitro. Mice lacking exhibited enlarged, histoarchitecturally abnormal brains, which resulted from increased proliferation, decreased death, enlarged size. Neurosphere cultures revealed a greater capacity for tripotent Pten-/- central nervous system cells, can be attributed, at least part, to...
Andreas Trumpp, Michael J. Depew, John L.R. Rubenstein, Bishop, and Gail R. Martin G.W. Hooper Foundation, Department of Microbiology, School Medicine, University California at San Francisco (UCSF), Francisco, 94143-0552 USA; Nina Ireland Laboratory Developmental Neurobiology, Psychiatry, UCSF, 94143-0984 Anatomy Program in Biology, 94143-0452 USA
Abstract Ewing's sarcoma is a member of family tumors (EFTs) and the second most common solid bone soft tissue malignancy children young adults. It associated in 85% cases with t(11;22)(q24:q12) chromosomal translocation that generates fusion 5′ segment EWS gene 3′ ETS FLI-1. The EWS-FLI-1 protein behaves as an aberrant transcriptional activator believed to contribute EFT development. However, induces growth arrest apoptosis normal fibroblasts, primary cells are permissive for its putative...