A5052795429- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Nutritional Studies and Diet
- Protein Degradation and Inhibitors
- Merger and Competition Analysis
- Mesenchymal stem cell research
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Global trade and economics
- Hematopoietic Stem Cell Transplantation
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Bone and Joint Diseases
- Nutrition, Genetics, and Disease
- Fatty Acid Research and Health
- Chronic Lymphocytic Leukemia Research
- Aquaculture Nutrition and Growth
- Platelet Disorders and Treatments
- Genomic variations and chromosomal abnormalities
- Immune cells in cancer
- Public Procurement and Policy
- Agriculture Sustainability and Environmental Impact
University Medical Centre Mannheim
2014-2025
University Hospital Heidelberg
2016-2025
Heidelberg University
2016-2025
University of Graz
2023
University of Mannheim
2022-2023
University Hospital Bonn
2019
Alliance Bioversity International - CIAT
2018
Palmetto Hematology Oncology
2016
Food and Agriculture Organization of the United Nations
2013-2015
Beltsville Human Nutrition Research Center
2014
The European Nutrition and Health Report is the first comprehensive assessment of present status nutrition health in Europe, available resources requirements for compatible representative data from different countries. 13 EU member states Norway have participated this project, pursuing three main goals: Compila
Abstract Background Lysyl oxidases (LOX/LOXL1-4) are crucial for cancer progression, yet their transcriptional regulation, potential therapeutic targeting, prognostic value and involvement in immune regulation remain poorly understood. This study comprehensively evaluates LOX/LOXL expression highlights types where targeting these enzymes developing LOX/LOXL-based models could have significant clinical relevance. Methods We assessed the association of with survival drug sensitivity via...
Somatic mutations in genes coding for splicing factors, e.g. SF3B1, U2AF1, SRSF2, and others are found approximately 50% of patients with Myelodysplastic Syndromes (MDS). These have been predicted to frequently occur early the mutational hierarchy disease therefore making them particularly attractive potential therapeutic targets. Recent studies cell lines engineered carry factor revealed a strong association elevated levels DNA:RNA intermediates (R-loops) dependency on proper ATR function....
// Liliana H. Mochmann 1 , Martin Neumann Eva K. von der Heide Verena Nowak 2 Anja A. Kühl 3 Jutta Ortiz-Tanchez Juliane Bock Wolf Hofmann Claudia D. Baldus Department of Hematology and Oncology, Charité University Medicine Berlin, Germany Hospital Mannheim, Gastroenterology, Infectiology Rheumatology, Correspondence: Baldus, email: Keywords : ERG, ERK, EMT, Chemoresistance Received September 26, 2013 Accepted December 3, Published 4, Abstract Overexpression the oncogene ERG (ETS-related...
Abstract The bone marrow (BM) stroma in myeloid neoplasms is altered and it hypothesized that this cell compartment may also harbor clonal somatically acquired mutations. By exome sequencing of vitro expanded mesenchymal stromal cells (MSCs) from n = 98 patients with myelodysplastic syndrome (MDS) 28 healthy controls we show these accumulate recurrent mutations genes such as ZFX (n 8/98), RANK 5/98), others. MDS derived MSCs display higher mutational burdens, increased replicative stress,...
<h3>Background</h3> Investigation of X-chromosome inactivation patterns (XCIP) by determination differential CpG-methylation has been widely applied for investigation female cell clonality. Using this approach the clonal origin various tumours corroborated. Controversially, strong age-related increase peripheral blood (PB) clonality in haematologically healthy subjects was reported. Recently, transcriptional XCIP ratio analysis challenged these results and questioned suitability methylation...
Food composition data play a key role in most nutrition related activities. The International Network of Data Systems (INFOODS) has contributed to improving the availability and quality food worldwide. INFOODS activities include publication regional international tables databases (e.g., Composition Database for Biodiversity) guidelines. Capacity development is an on-going activity through postgraduate classroom courses distance-learning modules. Training awareness-raising these efforts led...