A5046124661- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- Bone and Joint Diseases
- Peptidase Inhibition and Analysis
- Advanced MRI Techniques and Applications
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Pathology Studies
- Bone and Dental Protein Studies
- Hematological disorders and diagnostics
- Lanthanide and Transition Metal Complexes
- Multiple Myeloma Research and Treatments
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Micro and Nano Robotics
- Advanced Neuroimaging Techniques and Applications
- Cardiac tumors and thrombi
- Neuroblastoma Research and Treatments
Universitätsklinikum Erlangen
2016-2025
Johannes Gutenberg University Mainz
2024-2025
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2024
RWTH Aachen University
2024
European Society of Radiology
2022
University of Konstanz
2018-2021
University of Massachusetts Chan Medical School
2021
Comprehensive Cancer Center Erlangen
2021
Research Institute of Radiology
2018-2020
With whole-body magnetic resonance imaging (wb-MRI), almost the whole bone marrow compartment can be examined in patients with monoclonal plasma cell disease. Focal lesions (FLs) detected by spinal MRI have been of prognostic significance symptomatic multiple myeloma (sMM). In this study, we investigated FLs wb-MRI asymptomatic (aMM).Wb-MRI was performed 149 aMM. The presence and absence, as well number, for progression into sMM analyzed.FLs were present 28% patients. per se a number greater...
Group formation in living systems typically results from a delicate balance of repulsive, aligning, and attractive interactions. We found that mere motility change the individuals response to visual perception their peers induces group cohesion. tested this principle real system active particles whose motilities are controlled by an external feedback loop. For narrow fields view, gathered into cohesive nonpolarized groups without requiring reorientations. wider cohesion could be achieved...
Primary/secondary hyperoxalurias involve nephrocalcinosis-related chronic kidney disease (CKD) leading to end-stage disease. Mechanistically, intrarenal calcium oxalate crystal deposition is thought elicit inflammation, tubular injury and atrophy, involving the NLRP3 inflammasome. Here, we found that mice deficient in ASC adaptor protein failed develop nephrocalcinosis, compromising conclusions on CKD. In contrast, hyperoxaluric wild-type developed profound nephrocalcinosis. inhibition using...
Abstract Many microorganisms regulate their behaviour according to the density of neighbours. Such quorum sensing is important for communication and organisation within bacterial populations. In contrast living systems, where determined by biochemical processes, synthetic active particles can be controlled external fields. Accordingly they allow investigate how variations a density-dependent particle response affect self-organisation. Here we experimentally numerically demonstrate this...
Summary Bone marrow plasma cell infiltration is a crucial parameter of disease activity in monoclonal disorders. Until now, the only way to quantify such was bone biopsy or aspiration. Diffusion‐weighted imaging (DWI) magnetic resonance imaging‐technique that may mirror tissue cellularity by measuring random movements water molecules. To investigate if DWI capable assessing disease, we investigated 56 patients with multiple myeloma gammopathy undetermined significance, and 30 healthy...
Background: Rising criticism of currently available contrast agents for magnetic resonance imaging, either due to their side effects or limited possibilities in terms functional evoked the need safer and more versatile agents. We previously demonstrated suitability novel dextran-coated superparamagnetic iron oxide nanoparticles (SPION Dex ) biomedical applications safety biocompatibility. Methods: In present study, we investigated size-dependent cross-linking process these particles as well...
Papillon-Lefèvre syndrome (PLS) is characterized by nonfunctional neutrophil serine proteases (NSPs) and fulminant periodontal inflammation of unknown cause. Here we investigated extracellular trap (NET)-associated aggregation cytokine/chemokine-release/degradation normal NSP-deficient human mouse granulocytes. Stimulated with solid or soluble NET inducers, neutrophils formed aggregates both released degraded cytokines/chemokines. With increasing cell density, proteolytic degradation...
Objective Expression of dipeptidylpeptidase 4 ( DPP ‐4) identifies a dermal fibroblast lineage involved in scarring during wound healing. The role DDP ‐4 tissue fibrosis is, however, unknown. aim the present study was to evaluate as potential target for treatment patients with systemic sclerosis SS c). Methods skin biopsy samples and fibroblasts analyzed by real‐time polymerase chain reaction, immunofluorescence, Western blot analyses. activity modulated overexpression, knockdown,...
Abstract: Iron oxide-based contrast agents have been in clinical use for magnetic resonance imaging (MRI) of lymph nodes, liver, intestines, and the cardiovascular system. Superparamagnetic iron oxide nanoparticles (SPIONs) high potential as a agent MRI, but no intravenous oxide-containing are currently approved imaging. The aim our work was to analyze hemocompatibility immuno-safety new type dextran-coated SPIONs (SPIONdex) characterize these with ultra-high-field MRI. Key parameters...
Abstract Activation of proinflammatory macrophages is associated with the inflammatory state rheumatoid arthritis. Their polarization and activation are controlled by transcription factors such as NF-κB AP-1 factor member c-Fos. Surprisingly, little known about role c-Jun in macrophage activation. In this study, we show that mRNA protein levels increased following pro- or anti-inflammatory stimulations. Gene Ontology Kyoto Encyclopedia Genes Genomes pathway enrichment cluster analyses...
Abstract Accurate Magnetic Resonance Imaging (MRI) simulation is fundamental for high-precision stereotactic radiosurgery and fractionated radiotherapy, collectively referred to as radiotherapy (SRT), deliver doses of high biological effectiveness well-defined cranial targets. Multiple MRI hardware related factors well scanner configuration sequence protocol parameters can affect the imaging accuracy need be optimized special purpose treatment planning. SRT possible different organizational...
To examine if standard magnetic resonance (MR) imaging of the axial skeleton is sufficient for evaluation patients with multiple myeloma (MM) or monoclonal gammopathy undetermined significance (MGUS) whole-body MR necessary.A total 100 untreated MGUS (n = 27) any stages MM 73) were examined and skeleton. The study was approved by institutional ethics committee, written informed consent given. Spinal pattern ("no diffuse involvement" "diffuse as assessed from signal intensity spinal bone...
Chronic kidney disease (CKD) research is limited by the lack of convenient inducible models mimicking human CKD and its complications in experimental animals. We demonstrate that a soluble oxalate-rich diet induces stable stages male female C57BL/6 mice. Renal histology characterized tubular damage, remnant atubular glomeruli, interstitial inflammation, fibrosis, with extent tissue involvement depending on duration oxalate feeding. Expression profiling markers magnetic resonance imaging...
The application of the tumor-specific genomic fusion sequence as noninvasive biomarker for therapy monitoring in Ewing sarcoma (EwS) has been evaluated.EwS xenograft mouse models were used to explore detectability small plasma volumes and correlation EWSR1-FLI1 copy numbers with tumor burden. Furthermore, 234 blood samples from 20 EwS patients analyzed before during multimodal treatment. EWSR1 levels patients' quantified using droplet digital PCR compared calculated MRI or CT imaging...