A5030709807- Cancer Immunotherapy and Biomarkers
- Effects of Radiation Exposure
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Ultrasound and Hyperthermia Applications
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Head and Neck Cancer Studies
- Heat shock proteins research
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Nanoplatforms for cancer theranostics
- Cytomegalovirus and herpesvirus research
- Microbial Inactivation Methods
- CAR-T cell therapy research
- Inflammatory Biomarkers in Disease Prognosis
- Fibromyalgia and Chronic Fatigue Syndrome Research
Universitätsklinikum Erlangen
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Comprehensive Cancer Center Erlangen
2020-2025
Immunomedics (Germany)
2024
University of Maryland Center for Environmental Science
2023
Bayer (Germany)
2020-2021
Universitätsklinik für Strahlentherapie
2020
Universitätsklinikum Tübingen
2018
Morgan State University
2017
Radiation Oncology Associates
2010
Gut microbial dysbiosis is associated with the development of autoimmune disease, but mechanisms by which affects transition from asymptomatic autoimmunity to inflammatory disease are incompletely characterized. Here, we identify intestinal barrier integrity as an important checkpoint in translating inflammation. Zonulin family peptide (zonulin), a potent regulator for tight junctions, highly expressed mice and humans can be used predict arthritis. Increased serum zonulin levels accompanied...
Cell migration through connective tissue, or cell invasion, is a fundamental biomechanical process during metastasis formation. invasion usually requires adhesion to the extracellular matrix integrins. In some tumors, increased integrin expression associated with malignancy and Here, we have studied of cancer cells different α5β1 levels into loose dense 3D collagen fiber matrices. Using sorter, isolated from parental MDA-MB-231 breast two subcell lines expressing either high low amounts...
The potential of large language models in medicine for education and decision-making purposes has been demonstrated as they have achieved decent scores on medical exams such the United States Medical Licensing Exam (USMLE) MedQA exam. This work aims to evaluate performance ChatGPT-4 specialized field radiation oncology.
We previously demonstrated the suppressive effects of regulatory T cells (Treg cells) on osteoclast differentiation in vitro. In this article, we show that blood markers bone resorption inversely correlate with amount circulating Treg healthy controls and rheumatoid arthritis patients, further suggesting may control destruction vivo. Indeed, marrow from Foxp3-transgenic (Foxp3tg) mice fully protected human TNF transgenic (hTNFtg) TNF-alpha-induced destruction, whereas Foxp3-deficient...
The NALP3 inflammasome is activated by low intracellular potassium concentrations [K(+)](i), leading to the secretion of proinflammatory cytokine IL-1β. However, mechanism [K(+)](i) lowering after phagocytosis monosodium urate crystals still elusive. Here, we propose that endosomes containing fuse with acidic lysosomes. pH in phagolysosome causes a massive release sodium and raises osmolarity. This process balanced passive water influx through aquaporins cell swelling. dilutes values below...
Immunotherapy approaches currently make their way into the clinics to improve outcome of standard radiochemotherapy (RCT). The programed cell death receptor ligand 1 (PD-L1) is one possible target that, upon blockade, allows T cell-dependent antitumor immune responses be executed. To date, it unclear which RCT protocol and fractionation scheme leads increased PD-L1 expression thereby renders blockade this suppressive pathway reasonable. We therefore investigated impact radiotherapy (RT),...
Benign painful and inflammatory diseases have been treated for decades with low/moderate doses of ionizing radiation (LD-X-irradiation). Tissue macrophages regulate initiation resolution inflammation by the secretion cytokines acting as professional phagocytes. Having these pivotal functions, we were interested in how activated are modulated LD-X-irradiation, also regard to protection issues carcinogenesis. We set up an ex-vivo model which lipopolysaccharide pre-activated peritoneal (pMΦ)...
Inflammatory diseases are the result of complex and pathologically unbalanced multicellular interactions. For decades, low-dose X-irradiation therapy (LD-RT) has been clinically documented to exert an anti-inflammatory effect on benign chronic degenerative disorders. By contrast, experimental studies confirm effectiveness reveal underlying cellular molecular mechanisms still at their early stages. During last decade, however, modulation a multitude immunological processes by LD-RT explored...
In addition to locally controlling the tumor, hypofractionated radiotherapy (RT) particularly aims activate immune cells in RT-modified microenvironment. Therefore, we examined whether RT can dendritic (DCs), induce cell infiltration tumors, and how chronology of migration into tumors occurs gain knowledge for future definition radiation breaks inclusion immunotherapy. Colorectal cancer treatments offer only limited survival benefit, immunobiological principles additional therapies need be...