A5034405189- Effects of Radiation Exposure
- Enzyme-mediated dye degradation
- Cancer Cells and Metastasis
- Radiation Therapy and Dosimetry
- Microbial Metabolism and Applications
- Biochemical and biochemical processes
- Enzyme Catalysis and Immobilization
- Angiogenesis and VEGF in Cancer
- Cancer Treatment and Pharmacology
- Microtubule and mitosis dynamics
- Heat shock proteins research
- Mesenchymal stem cell research
- Advanced Radiotherapy Techniques
- Cannabis and Cannabinoid Research
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Analytical chemistry methods development
- Cancer-related Molecular Pathways
- Colorectal and Anal Carcinomas
- Ultrasound and Hyperthermia Applications
- Fatty Acid Research and Health
- Radical Photochemical Reactions
- Piperaceae Chemical and Biological Studies
- Heme Oxygenase-1 and Carbon Monoxide
University of Rostock
2014-2025
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2009
Universität Greifswald
2005-2008
Czech Academy of Sciences, Institute of Microbiology
2008
Universitätsmedizin Rostock
2008
Dendritic cells (DCs), as professional antigen presenting (APCs), are members of the innate immune system and function key players during induction phase adaptive responses. Uptake, processing presentation antigens direct outcome towards either tolerance or immunity. The among most highly radiosensitive in body. immune-suppressive effect high doses ionizing radiation (HD-IR), increasing apoptosis all splenocyte subpopulations, is well-demonstrated. On other hand, effects low (LD-IR) on...
Inflammatory diseases are the result of complex and pathologically unbalanced multicellular interactions. For decades, low-dose X-irradiation therapy (LD-RT) has been clinically documented to exert an anti-inflammatory effect on benign chronic degenerative disorders. By contrast, experimental studies confirm effectiveness reveal underlying cellular molecular mechanisms still at their early stages. During last decade, however, modulation a multitude immunological processes by LD-RT explored...
To enhance the treatment of tumors that are resistant to radio- and chemotherapy while minimizing side effects radiochemotherapy, researchers continuously seeking new active compounds for use in combination with radiotherapy. Therefore, aim our study was examine cytotoxic radiosensitizing an extract from St. John’s Wort (Hypericum perforatum), referred as HP01, on human epithelial tumor cells vitro. The growth MCF-7 (breast carcinoma) HT-29 (colon examined under influence HP01. In radiation,...
Corollosporine isolated from the marine fungus Corollospora maritima and N-analogous corollosporines are antimicrobial substances. Owing to basic structure of corollosporines, they have become an attractive target for laccase-catalyzed derivatisation. In this regard we report on straightforward amination dihydroxylated arenes with corollosporines. biological assays obtained products more active than parent compounds.
Background . In many European countries, patients with a variety of chronical inflammatory diseases are treated low-dose radiotherapy (LD-RT). contrast to high-dose irradiation given tumor patients, little is known about radiobiological mechanisms underlying this clinical successful LD-RT application. The objective study was gain better insight into the modulation reactions after on basis endothelial cells (EC) as major participants and regulators inflammation. Methods Three murine EC lines...
Abstract Seven novel β‐lactam antibiotics with activities against Gram‐positive bacterial strains, among them methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant enterococci, were synthesized by amination of 2,5‐dihydroxyphenylacetic acid in usable yields (30–60%). These products protected mice an infection S. lethal to the control animals. The results show usefulness laccase for synthesis potential new antibiotics, addition interdependence substrates, amino coupling...
Purpose: The application of radiation therapy (RT) is not only used to treat cancer, in Germany, it also an accepted and empirically established treatment patients with benign diseases at low doses. immune modulatory response generated by low-dose RT has a supporting anti-inflammatory effect within the inflammation-related diseases. aim this study was investigate ionizing (IR) on expression secretion inflammatory mediators endothelial cells (ECs) exposed moderate doses.Methods: Non-activated...
As there is a growing number of long-term cancer survivors, the incidence carcinogenesis as late effect radiotherapy getting more and into focus. The risk for development secondary malignant neoplasms might be significantly increased due to exposure healthy tissue outside target field neutrons, in particular proton therapy. Thus far, radiobiological effects these neutrons comparison with photons on normal breast cells have not been sufficiently characterised. MCF10A were irradiated doses up...
(1) Background: Emerging interest of physicians to use adipose-derived stem cells (ADSCs) for regenerative therapies and the fact that low-dose irradiation (LD-IR ≤ 0.1 Gy) has been reported enhance proliferation several human normal bone-marrow cells, but not tumor lead idea improving cell via radiation. Therefore, aim this study was investigate unwanted side effects, as well proliferation-stimulating mechanisms LD-IR on ADSCs. (2) Methods: To avoid donor specific ADSCs isolated from mamma...
Purpose . Most tumours are characterized by an inflammatory microenvironment, and correlations between inflammation cancer progression have been shown. Endothelial cells (ECs), as part of the tumour play a crucial role in processes well angiogenesis could be critical targets therapy like irradiation. Therefore, present study we investigated effect ionizing radiation on endothelial under conditions their interactions with cells. Methods Nonactivated TNF- α treatment-activated human EC...
Epothilone B was shown to have promising chemo- and radiosensitizing effects on cells, but the mechanisms underlying cell death remain ambiguous. The aim of study examine selected pathways basis FaDu A549 cells. Western blot analyses were used for investigation specific apoptotic markers. Immunofluorescence imaging flow cytometry utilized examination mechanisms. DNA-staining studying influence epothilone micronucleus rate. We showed that can initiate via apoptosis mitotic catastrophe,...