Palladium-catalyzed carbonylation reactions of aromatic halides in the presence various nucleophiles have undergone rapid development since pioneering work Heck and co-workers 1974, such that nowadays a plethora palladium catalysts are available for different carbonylative transformations. The carboxylic acid derivatives, aldehydes, ketones prepared this way important intermediates manufacture dyes, pharmaceuticals, agrochemicals, other industrial products. In Review, recent academic...

Abstract In this Minireview, the synthesis of amines by amination alcohols, means so‐called borrowing hydrogen methodology, is presented. Compared to other synthetic methodologies for amines, these transformations are highly attractive because often alcohols readily available starting materials, some them on a large scale from renewable sources. addition, produces water as only by‐product, which makes process potentially environmentally benign. Already today, lower alkyl produced in bulk...

A MOF sets the stage to make amines Reductive amination is a common method that chemists use carbon-nitrogen bonds. The reaction, which often requires precious metal catalysts, couples ammonia or other with carbonyl compounds and then hydrogen. Jagadeesh et al. report class of nonprecious cobalt nanoparticles catalyze this reaction across very broad range substrates, including complex molecules pharmaceutical interest (see Perspective by Chen Xu). was first embedded in metal-organic...

Building bridges: Palladium-catalyzed cross-coupling reactions of aryl halides and related compounds allow the expeditious controlled synthesis important carbon-based scaffolds (see scheme). Their essential role in organic chemistry has resulted such being recognized by Nobel Prize for Chemistry 2010.

Carbon monoxide was discovered and identified in the 18th century. Since first applications industry 80 years ago, academic industrial laboratories have broadly explored CO's use chemical reactions. Today organic chemists routinely employ CO chemistry to synthesize all kinds of carbonyl compounds. Despite these achievements a century carbonylation catalysis, many important research questions challenges remain. Notably, apart from developments, applies reactions with on bulk scale. In fact,...

Abstract Palladium‐catalyzed carbonylation reactions of alkenes and alkynes with different nucleophiles have undergone rapid development ever since the seminal work Reppe back in 1930s. Nowadays, a plethora palladium catalysts various synthetic protocols are available for synthesis valuable carboxylic acids acrylic as well their derivatives. Herein, we summarize recent catalyst developments selected organic applications this area.

Abstract Um eine CO‐Gruppe reicher : (Hetero‐)Arene sind aus der industriellen Herstellung von Agrochemikalien, Farbstoffen, Pharmaka etc. nicht wegzudenken. Während vergangenen Jahrzehnte wurden übergangsmetallkatalysierte Kupplungen Arylhalogeniden mit Nucleophilen aller Art entwickelt. Dieser Aufsatz fasst aktuelle Fortschritte auf dem Gebiet palladiumkatalysierten Carbonylierungen und ähnlichen Verbindungen zusammen (siehe Schema). magnified image Palladiumkatalysierte in Gegenwart...

Abstract A novel catalytic hydrogen‐autotransfer protocol for the atom‐efficient α‐alkylation of ketones with readily available alcohols is presented. The use manganese complexes bearing non‐innocent PNP pincer ligands enabled functionalization a broad range valuable ketones, including 2‐oxindole, estrone 3‐methyl ether, and testosterone. Mechanistic investigations suggest participation an intramolecular amidate‐assisted alcohol‐dehydrogenation process.

Atom efficiency and selectivity are the key features of first homogeneously catalyzed amination secondary alcohols with ammonia to give corresponding primary amines (see scheme). This novel method relies on commercially available catalyst [Ru3(CO)12]/cataCXium PCy does not require any additional source hydrogen.

A general and highly regioselective synthesis of pyrroles via ruthenium-catalyzed three-component reactions has been developed. variety ketones including less reactive aryl alkyl substrates were efficiently converted in combination with different type amines vicinal diols into various substituted reasonable to excellent isolated yields. Additionally, α-functionalized gave synthetically interesting amido-, alkoxy-, aryloxy-, phosphate-substituted a straightforward manner. The synthetic...

Selectively esterified: Primary alcohols react with dioxygen as a benign oxidant in palladium-catalyzed oxidative esterification (see scheme). The corresponding aldehydes and esters are formed highly selectively depending on the catalyst system. reactions take place presence of commercially available ligands without need for additional organic hydrogen acceptors. Detailed facts importance to specialist readers published ”Supporting Information”. Such documents peer-reviewed, but not...

It's a snap: A novel catalytic three-component coupling reaction using simple and easily available substrates leads to wide range of substituted pyrroles with high regioselectively (see scheme; Xantphos=9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene). As service our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising...

A carbonylation path to a nylon precursor Adipic acid and its esters are manufactured on massive scale, primarily produce nylon. However, the standard route requires large quantities of corrosive nitric acid. J. Yang et al. present an efficient alternative whereby palladium catalyst adds carbon monoxide each end butadiene (see Perspective by Schaub). Both reactants available at commodity reaction produces no by-products. An optimized bidentate phosphine ligand bearing pyridine substituent...

Abstract Carbonylation reactions of alkenes constitute the most important industrial processes in homogeneous catalysis. Despite tremendous progress this transformation, development advanced catalyst systems to improve their activity and widen range feedstocks continues be essential for new practical applications. Herein a palladium based on 1,2-bis(( tert -butyl(pyridin-2-yl)phosphanyl)methyl)benzene L3 (py t bpx) is rationally designed synthesized. Application system allows general...

Abstract The production of primary benzylic and aliphatic amines, which represent essential feedstocks key intermediates for valuable chemicals, life science molecules materials, is central importance. Here, we report the synthesis this class amines starting from carbonyl compounds ammonia by Ru-catalyzed reductive amination using H 2 . Key to success use a simple RuCl (PPh 3 ) catalyst that empowers >90 various linear branched benzylic, heterocyclic, under industrially viable scalable...

Zeolitic imidazolate frameworks derived Fe1-N-C catalysts with isolated single iron atoms have been synthesized and applied for selective ammoxidation reactions. For the preparation of different Fe-based materials, benzylamine as an additive proved to be essential tune morphology size ZIFs resulting in uniform smaller particles, which allow stable atomically dispersed Fe-N4 active sites. The optimal catalyst achieves efficient synthesis various aryl, heterocyclic, allylic, aliphatic nitriles...

The first general palladium-catalyzed carbonylative vinylation of aryl halides with olefins in the presence CO has been developed. Applying a catalyst system consisting [(cinnamyl)PdCl](2) and bulky imidazolyl-phosphine ligand L1 allows for efficient selective synthesis α,β-unsaturated ketones under mild reaction conditions. Starting from easily available olefins, versatile building blocks can be prepared straightforward manner. generality functional group tolerance this novel protocol is...