Abstract In this Minireview, the synthesis of amines by amination alcohols, means so‐called borrowing hydrogen methodology, is presented. Compared to other synthetic methodologies for amines, these transformations are highly attractive because often alcohols readily available starting materials, some them on a large scale from renewable sources. addition, produces water as only by‐product, which makes process potentially environmentally benign. Already today, lower alkyl produced in bulk...

A general and highly regioselective synthesis of pyrroles via ruthenium-catalyzed three-component reactions has been developed. variety ketones including less reactive aryl alkyl substrates were efficiently converted in combination with different type amines vicinal diols into various substituted reasonable to excellent isolated yields. Additionally, α-functionalized gave synthetically interesting amido-, alkoxy-, aryloxy-, phosphate-substituted a straightforward manner. The synthetic...

It's a snap: A novel catalytic three-component coupling reaction using simple and easily available substrates leads to wide range of substituted pyrroles with high regioselectively (see scheme; Xantphos=9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene). As service our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising...

Despite the widespread applications of α-hydroxyalkyl cyclic amines, direct and diverse access to such a class unique vicinal amino alcohols still remains, date, challenge. Here, through strategy electroreductive α-hydroxyalkylation inactive N-heteroarenes with ketones or electron-rich arylaldehydes, we describe room temperature approach for construction which features broad substrate scope, operational simplicity, high chemoselectivity, no need pressurized H2 gas transition metal catalysts....

ConspectusThe selective functionalization/transformation of ubiquitous pyridine-fused N-heteroarenes is a practical method to synthesize structurally novel N-heterocycles, which important for the development medicines, bioactive agents, agrochemicals, materials, ligands, sensors, pigments, dyes, etc. However, owing thermodynamic stability, kinetic inertness, and lone electron pair–induced catalyst deactivation N-heteroarenes, limited strategies (e.g., C–H activation/functionalization,...

Diamination of diols: The first homogeneously catalyzed diaminations primary and secondary diols with ammonia give the corresponding diamines. Other as well alcohols including hydroxy-substituted esters can also be efficiently converted to amines. This atom-efficient selective amination method proceeds in an atmosphere without additional hydrogen sources. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or...

Amid(e) them all: primary carboxamides and ureas react with aromatic aliphatic amines in the presence of a copper catalyst to give wide range functionalized amides.

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTConversion of Pyridine to Imidazo[1,2-a]pyridines by Copper-Catalyzed Aerobic Dehydrogenative Cyclization with Oxime EstersHuawen Huang, Xiaochen Ji, Xiaodong Tang, Min Zhang, Xianwei Li, and Huanfeng Jiang*View Author Information School Chemistry Chemical Engineering, South China University Technology, Guangzhou 510640, P. R. China[email protected]Cite this: Org. Lett. 2013, 15, 24, 6254–6257Publication Date (Web):November 21, 2013Publication...

The tetracyclic carbon skeleton of hainanolidol and harringtonolide was efficiently constructed by an intramolecular oxidopyrylium-based [5 + 2] cycloaddition. An anionic ring-opening strategy developed for the cleavage ether bridge in 8-oxabicyclo[3.2.1]octenes derived from Conversion cycloheptadiene to tropone realized a sequential [4 cycloaddition, Kornblum–DeLaMare rearrangement, double elimination. biomimetic synthesis also confirmed.

Give me an N: The catalytic amination of α-hydroxy amides with a variety amines, including anilines, primary and secondary aliphatic ammonia, yields wide range α-amino (see scheme). This atom-efficient protocol proceeds efficiently in the presence commercially available [Ru3(CO)12]/DCPE catalyst system. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made submitted by authors. Please...

A base-promoted three-component coupling of carbon dioxide, amines, and N-tosylhydrazones has been developed. The reaction is suggested to proceed via a carbocation intermediate constitutes an efficient versatile approach for the synthesis wide range organic carbamates. advantages this method include use readily available substrates, excellent functional group tolerance, substrate scope, facile work-up procedure.

A novel and highly regioselective ammonium iodide-induced nonradical sulfenylation method for the construction of a C–S bond was developed via C–H functionalization. With DMSO or R1SO2NHNH2 as sulfenylating agent, MeS- R1S-substituted flavone derivatives were obtained in good yields. This enriches current formation chemistry, making it valuable practical pharmaceutical industry.

Until now, the selective (hetero)aryl C–H alkylation without assistance of directing groups or preinstallation functionalities still remains a highly challenging goal. Herein, by developing acid-resistant multispherical cavity carbon-supported cobalt oxide nanocatalysts (CoOx/MSCC) and hydrogen transfer-mediated activation mode for nonactivated N-heteroaromatics, we present direct reductive quinolyl isoquinolyl β-C–H with various aldehydes as alkylating agents. The catalytic transformation...

By employing a commercially available Ru3(CO)12/Xantphos/t-BuOK catalyst system, novel and straightforward ruthenium-catalyzed dehydrogenative synthesis of 2-arylquinazolines has been demonstrated. A series 2-aminoaryl methanols were efficiently converted in combination with different types benzonitriles into various desired products moderate to good yields upon isolation. The synthetic protocol proceeds the advantages operational simplicity, high atom efficiency, broad substrate scope, no...

A general catalytic hydrogen transfer-mediated α-functionalization of 1,8-naphthyridines is reported for the first time that benefits from a activation mode non-activated pyridyl cores. The α-site selectively couples with C8-site various tetrahydroquinolines (THQs) to afford novel α-functionalized tetrahydro 1,8-naphthyridines, class synthetically useful building blocks and potential candidates discovery therapeutic bio-active products. utilization THQs as inactive donors (HDs) appears be...

Difluoromethylation is a straightforward and widely applied strategy used to incorporate HCF2 into organic molecules. In contrast, cyanation reagents are typically volatile or highly toxic, they require harsh reaction conditions. Incorporation of both CN molecules, such as alkenes, worthwhile but challenging task. A method for photocatalyzed cyanodifluoromethylation alkenes has been developed, which employs Ph3 P+ CF2 CO2- /NaNH2 (or NH3 ) reagent system. functions the carbon source. cyanide...

Abstract Highly selective and direct electroreductive ring‐opening carboxylation of epoxides with CO 2 in an undivided cell is reported. This reaction shows broad substrate scopes within styrene oxides under mild conditions, providing practical scalable access to important synthetic intermediate β ‐hydroxy acids. Mechanistic studies show that functions not only as a carboxylative reagent this but also promoter enable efficient chemoselective transformation additive‐free electrochemical...

ZIF-derived metal/N-doped porous carbon have emerged as efficient heterogeneous catalysts in organic reactions, due to controllable 3D structure, uniformly dispersed metal sites, tunable metal–support interactions and superior catalytic performance.

Despite the extensive applications, selective and diverse access to N,N'-diarylethane-1,2-diamines remains, date, a challenge. Here, by developing bifunctional cobalt single-atom catalyst (CoSA-N/NC), we present general method for direct synthesis of such compounds via reductive coupling cheap abundant nitroarenes formaldehyde, featuring good substrate functionality compatibility, an easily accessible base metal with excellent reusability, high step atom efficiency. Mechanistic studies...

Despite their significant importance to numerous fields, the difficulties in direct and diverse synthesis of α-hydroxy-γ-lactams pose substantial obstacles practical applications. Here, we designed a nitrogen TiO2 co-doped graphitic carbon-supported material with atomically dispersed cobalt sites (CoSA-N/NC-TiO2), which was successfully applied as multifunctional catalyst establish general method for construction from cheap abundant nitro(hetero)arenes, aldehydes, H2O alkynoates. The...

Tetra- and pentasubstituted polyfunctional dihydropyrroles have been concisely synthesized in high yields by two different processes of the one-pot multicomponent reactions (MCRs) but-2-ynedioates 1, amines 2, aldehydes 3 at room temperature or 70 °C. The first one involves a domino hydroamination/nucleophilic addition/amidation-cyclization process leads to formation tetrasubstituted 4. second undergoes hydroamination/amidation/intramolecular cyclization/imine-enamine tautomerization...