A5100323671- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Radical Photochemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Cyclopropane Reaction Mechanisms
- Catalytic Cross-Coupling Reactions
- Oxidative Organic Chemistry Reactions
- Synthesis and Biological Evaluation
- Fluorine in Organic Chemistry
- Multicomponent Synthesis of Heterocycles
- Synthesis of heterocyclic compounds
- Synthesis and biological activity
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Organophosphorus compounds synthesis
- Organoselenium and organotellurium chemistry
- Vanadium and Halogenation Chemistry
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Nanomaterials for catalytic reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Organoboron and organosilicon chemistry
- Quinazolinone synthesis and applications
Second Affiliated Hospital of Zhejiang University
2025
Qufu Normal University
2015-2024
Qinghai Tibetan Hospital
2018-2024
Northwest Institute of Plateau Biology
2018-2024
Chinese Academy of Sciences
2013-2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
Hefei Institutes of Physical Science
2024
Nanjing Forestry University
2023
Sichuan Agricultural University
2023
The crème de la crème! A practical and simple Bu4NI-catalyzed CO bond formation was achieved by using a cross-dehydrogenative coupling (CDC) reaction with tert-butyl hydroperoxide (TBHP) as the ultimate oxidant (see scheme; R1=aryl, heteroaryl, alkyl; R2, R3=alkyl, alkyl halide). This approach is most straightforward method to date for synthesis of α-acyloxy ethers. plausible mechanism has been proposed. Detailed facts importance specialist readers are published "Supporting Information"....
The first copper-catalyzed oxysulfonylation reaction of alkenes with dioxygen and sulfonylhydrazides for the construction β-ketosulfones has been developed under mild conditions without any ligand or additive.
A novel and efficient visible-light-induced C(sp2)–H/N–H cross-dehydrogenative coupling (CDC)-amination with both primary secondary aliphatic amines at room temperature in air is developed. This photocatalytic reaction allows the direct formation of 3-aminoquinoxalin-2(1H)-ones via CDC-amination absence any external oxidant added from outside. Preliminary mechanistic studies reveal that present proceeds through a radical process.
A novel and metal-free procedure has been developed for the construction of 3-sulfonated coumarins via direct difunctionalization alkynoates with sulfonylhydrazides. The present protocol, which simply utilizes TBAI as catalyst TBHP oxidant, provides a convenient highly efficient approach to construct series sulfonated high regioselectivity good functional group tolerance.
A facile visible-light-driven method has been developed to construct sulfoxides from aryldiazo sulfones and thiols in air under photocatalyst-free conditions.
A new tert-butyl peresters synthesis directly from aldehydes and TBHP was developed viaBu4NI-catalyzed aldehyde C−H oxidation. Mechanistic studies suggest that the protocol proceeds via a radical process. Combining method with Kharasch–Sosnovsky reaction offers practical approach for of allylic esters simple alkenesvia two-step one-pot procedure.
A convenient and practical metal-free visible-light-promoted method to synthesize 3-oxyalkylated quinoxalin-2(1H)-ones was developed at room temperature. The present transformation could be accomplished through Rose Bengal-catalyzed C–H/C–H cross-dehydrogenative-coupling of quinoxalin-2(H)-ones with simple ethers, providing an efficient operationally access various moderate good yields.
A catalyst-free procedure has been developed for the construction of sulfonated oxindoles <italic>via</italic> direct arylsulfonylation activated alkenes with sulfinic acids.
A direct and straightforward approach for highly regioselective thiocyanation of imidazoheterocycles through sp2 C–H functionalization has been realized at room temperature. Various C-3 thiocyanated imidazopyridines are formed in moderate to good yield. The present method exhibits a mild selective access variety imidazopyridine derivatives pharmacological interest.
A visible-light-induced strategy has been established for the synthesis of 3-sulfonyl and 3-sulfenyl azaspiro[4,5]trienones at room temperature in air.
A novel and convenient silver-mediated radical cyclization method for the synthesis of coumarin derivatives via direct difunctionalization alkynoates with α-keto acids through double C-C bond formation under mild conditions has been developed. This new is highly efficient practical, starting materials are readily prepared. The present should provide a useful strategy construction motifs.
Highly efficient visible-light initiated direct oxysulfonylation of alkenes with sulfinic acids leading to β-ketosulfones has been realized under metal-free conditions.
A novel and direct oxidative spirocyclization of arylpropiolamides with sulfonylhydrazides leading to 3-sulfonated azaspiro[4,5]trienones has been developed under metal-free conditions. The reaction is performed in a tandem manner constituted by the sequential sulfonylation alkynes, ipso-carbocyclization, dearomatization, hydration, oxidation processes, providing convenient efficient approach various sulfonated azaspiro[4,5] trienones biological importance.
A selective synthesis of sulfoxides from alkenes and thiols was established by visible-light photoredox catalysis in air at room temperature.
A metal-free and cost-effective synthesis protocol has been initially proposed for the construction of CF3-containing oxindoles via direct oxidative trifluoromethylation activated alkenes with Langlois' reagent (CF3SO2Na). The present methodology, which utilizes very cheap CF3 a simple oxidant, provides convenient practical approach to wide variety functional groups.
The direct use of sulfinic acids as an odorless sulfur source to construct hetroaryl sulfides through a photoredox process has been realized at room temperature for the first time.
A metal-free oxidative coupling of methyl ketones and primary or secondary amines to α-ketoamides has been developed. Four intermediates, α-iodoketone, α-aminoketone, iminium intermediate, α-hydroxy amine have identified through a series control experiments. The atom-economic methodology can be scaled-up, tolerates variety functional groups, is operationally simple.
Visible-light-mediated procedure has been developed for the synthesis of 3-acyl quinoxalin-2(1<italic>H</italic>)-ones through acridine red catalyzed decarboxylative acylation α-oxo-carboxylic acids with quinoxalin-2(1<italic>H</italic>)-ones.
A novel Cu-catalyzed direct hydrosulfonylation of alkynes with arylsulfinic acids for the synthesis (E)-vinyl sulfones has been realized under mild conditions 100% atom efficiency. The present protocol provides an attractive approach to various vinyl in good excellent yields, advantages operation simplicity, economy, and high stereo- regioselectivities.