A5100673976- Advanced biosensing and bioanalysis techniques
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Advanced Nanomaterials in Catalysis
- Electrochemical sensors and biosensors
- Synthesis and Catalytic Reactions
- Electrochemical Analysis and Applications
- Nanocluster Synthesis and Applications
- Oxidative Organic Chemistry Reactions
- Advanced Photocatalysis Techniques
- Biosensors and Analytical Detection
- Radical Photochemical Reactions
- Molecular Sensors and Ion Detection
- Conducting polymers and applications
- Polymer Surface Interaction Studies
- Acoustic Wave Resonator Technologies
- Analytical Chemistry and Chromatography
- Advanced Biosensing Techniques and Applications
- Catalytic Cross-Coupling Reactions
- Synthesis and Biological Evaluation
- Surface Modification and Superhydrophobicity
- Nanomaterials for catalytic reactions
- Analytical Chemistry and Sensors
- Carbon and Quantum Dots Applications
Huzhou University
2020-2025
Henan University
2009-2025
Sun Yat-sen University
2021-2025
Sun Yat-sen University Cancer Center
2025
Third People's Hospital of Huzhou
2025
Qufu Normal University
2015-2024
Northwest A&F University
2016-2024
Shandong University
2009-2024
Tsinghua University
2005-2024
Chinese Academy of Sciences
2013-2024
A simple and sensitive fluorescent assay for detecting alkaline phosphatase (ALP) based on the inner filter effect (IFE) has been proven, which is conceptually different from previously reported ALP assays. In this sensing platform, N-doped carbon dots (CDs) with a high quantum yield of 49% were prepared by one-pot synthesis directly used as fluorophore in IFE. p-Nitrophenylphosphate (PNPP) was employed to act an substrate, its enzyme catalytic product (p-nitrophenol (PNP)) capable...
The first copper-catalyzed oxysulfonylation reaction of alkenes with dioxygen and sulfonylhydrazides for the construction β-ketosulfones has been developed under mild conditions without any ligand or additive.
A novel and efficient visible-light-induced C(sp2)–H/N–H cross-dehydrogenative coupling (CDC)-amination with both primary secondary aliphatic amines at room temperature in air is developed. This photocatalytic reaction allows the direct formation of 3-aminoquinoxalin-2(1H)-ones via CDC-amination absence any external oxidant added from outside. Preliminary mechanistic studies reveal that present proceeds through a radical process.
Bimetallic alloying gold-silver nanoclusters (Au-AgNCs) have been synthesized by a one-pot biomineralization synthesis route at vital molar ratio of Au/Ag precursors in the protein matrix. Unexpectedly, prepared Au-AgNCs could exhibit dramatically enhanced red fluorescence, which is about 6.5-fold and 4.7-fold higher than that common AuNCs core-shell Au@AgNCs, respectively. A rapid, selective, ultrasensitive fluorimetric method has thereby developed using as fluorescent probes toward...
Background: The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear. Method: Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 examined for by flow cytometry cytokine specific immunoassays. Findings: Of enrolled, 13 severe cases showed significant sustained decreases in counts but increases neutrophil than 27 mild cases. Further analysis demonstrated T...
We present an improved method to prepare carboxylic acid (COOH) and amine (NH2) terminated self-assembled monolayers (SAMs) of alkanethiolates. In this method, a small amount CF3COOH (for COOH−SAM) or N(CH2CH3)3 NH2−SAM) is added into the ethanolic solution alkanethiols during SAM formation. The freshly formed COOH− NH2−SAMs are then rinsed with NH4OH CH3COOH, respectively. Both SAMs prepared show better quality in terms surface chemical composition, roughness, wettability as measured by...
A novel and metal-free procedure has been developed for the construction of 3-sulfonated coumarins via direct difunctionalization alkynoates with sulfonylhydrazides. The present protocol, which simply utilizes TBAI as catalyst TBHP oxidant, provides a convenient highly efficient approach to construct series sulfonated high regioselectivity good functional group tolerance.
A metal-free tandem radical addition/cyclization reaction of activated alkenes and alcohols has been developed. The process provides an efficient atom economical access to various valuable hydroxyl-containing oxindoles through the direct sp3 C–H functionalization alcohols.
Albumin derived from chickpea was hydrolyzed sequentially using Alcalase and Flavorzyme proteases for production of antioxidant peptides. To identify peptides, albumin hydrolysate (CAH) fractionated size exclusion chromatography (G-25) methods. Antioxidant free radical-scavenging activities peptides purified the CAH were evaluated reducing power assays with 1,1-diphenyl-2-pycrylhydrazyl (DPPH) TEAC as well hydroxyl assays. The results demonstrated that peptide (CPe)-III exhibited highest...
Abstract A mild and efficient silver‐catalyzed acylarylation of activated alkenes with easily available α‐oxocarboxylic acids has been developed. The reactions provide a rapid access to variety functionalized oxindoles via tandem decarboxylative radical cyclization strategy. This transformation proceeds well under reaction conditions exhibits excellent functional group tolerance, affording the desired in good yields. magnified image
The decarboxylative cross-coupling reactions of carboxylic acids have emerged as an efficient strategy for the C-C bond and C-X formations. In this field, α-keto has been developed attractive to introduce a carbonyl group into versatile organic molecules. particular, radical-mediated attracted much attention chemists owing their mild conditions, excellent functional tolerance high reactivity. review, we highlight recent advances in radical acylation acids.
A convenient and practical metal-free visible-light-promoted method to synthesize 3-oxyalkylated quinoxalin-2(1H)-ones was developed at room temperature. The present transformation could be accomplished through Rose Bengal-catalyzed C–H/C–H cross-dehydrogenative-coupling of quinoxalin-2(H)-ones with simple ethers, providing an efficient operationally access various moderate good yields.
An efficient silver-catalyzed oxidative cyclization of acrylamides with 1,3-dicarbonyl compounds is described. It proceeds through a tandem radical addition/cyclization process, in which two new C-C bonds were formed. Furthermore, the same concept can also be extended to reaction easily available ketones and acrylamides.
A catalyst-free procedure has been developed for the construction of sulfonated oxindoles <italic>via</italic> direct arylsulfonylation activated alkenes with sulfinic acids.
A direct and straightforward approach for highly regioselective thiocyanation of imidazoheterocycles through sp2 C–H functionalization has been realized at room temperature. Various C-3 thiocyanated imidazopyridines are formed in moderate to good yield. The present method exhibits a mild selective access variety imidazopyridine derivatives pharmacological interest.
A visible-light-induced strategy has been established for the synthesis of 3-sulfonyl and 3-sulfenyl azaspiro[4,5]trienones at room temperature in air.
Abstract Chemoselective hydrogenation of 3‐nitrostyrene to 3‐vinylaniline is quite challenging because competitive activation the vinyl group and nitro over most supported precious‐metal catalysts. A precatalyst comprised thiolated Au 25 nanoclusters on ZnAl‐hydrotalcite yielded gold catalysts a well‐controlled size (ca. 2.0 nm)—even after calcination at 500 °C. The catalyst showed excellent selectivity (>98 %) with respect 3‐vinylaniline, complete conversion broad reaction duration...
Radically changing benzyls: An efficient method for the benzylarylation of activated alkenes has been developed through a copper-catalyzed tandem radical addition/cyclization strategy (see scheme). This oxidative coupling between acrylamides and benzylic hydrocarbons provides access to diverse alkyl-substituted oxindoles in good excellent yields. A variety functional groups were tolerated this transformation (TBPB=tert-butylperoxy benzoate). As service our authors readers, journal supporting...
A novel and convenient silver-mediated radical cyclization method for the synthesis of coumarin derivatives via direct difunctionalization alkynoates with α-keto acids through double C-C bond formation under mild conditions has been developed. This new is highly efficient practical, starting materials are readily prepared. The present should provide a useful strategy construction motifs.